Clinical Presentation and Outcome of Management of Congenital Heart Diseases Associated with Down Syndrome in a Tertiary Care Hospital

Introduction: Treatment of children with Down syndrome having congenital heart defects has not been reported well in Bangladesh. This study has been carried out to inform practitioners about findings from cases in Combined Military Hospital, Dhaka. Methods: Three years retrospective observational study (clinical data, hospital course and follow-up) was carried out on 114 patients (49 males and 65 females, age range 1 month to 12 years) who underwent diagnostic and therapeutic work up in the pediatric cardiology department CMH Dhaka between January 2018 and December 2020. Results: Among 114 patients ,64 were (57%) were infants and 50 were older children (43%) , twenty-five had congestive cardiac failure and eighteen had hypothyroidism. The study showed that 33.3% were atrioventricular septal defect (AVSD), 28.1% were patent ductus arteriosus (PDA),8.75% were tetralogy of Fallot (TOF) ,5.25% were coartation of aorta (COA) ,3.5% were patent ductus arteriosus with coarctation of aorta 3.5%, double outlet right ventricle with pulmonary stenosis were 3.5%, ventricular septal defect were 7% whereas atrial septal defect along with ventricular septal defect were 5.3% ,atrial septal defect were 3.5%, transposition of great arteries with multiple ventricular septal defect were 1.8%.Forty (35%) patients using per cutaneous intervention,had 100% procedural success and no mortality .45 patients underwent surgery,few of them were not operated due to severe pulmonary hypertension. Conclusion: Congenital heart disease was more frequent in DS children,having worse prognosis.Children with DS required special attention due to increased risk of pulmonary hypertension. Delayed treatment was an important risk factor for poor prognosis.So early diagnosis is needed in order to provide optimal intervention and surgery ,before occurrence of irreversible PAH. J Bangladesh Coll Phys Surg 2023; 41: 7-14

• Publication year

  2022

• Venue

  Journal of Bangladesh College of Physicians and Surgeons

• Publication date

  2022-12-31

• Fields of study

  Not labeled

• Identifiers
  DOI 10.3329/jbcps.v41i1.63256
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar

• No claims are published for this paper.

• No concepts are published for this paper.

• Down’s Syndrome with Congenital Heart Disease: Our Surgical Experience

  2020cited by this paper
• Infants Born with Down Syndrome: Burden of Disease in the Early Neonatal Period

  2017cited by this paper
• Dynamics in prevalence of Down syndrome in children with congenital heart disease

  2017cited by this paper
• Clinical and Parental Status of Patients with Congenital Heart Disease Associated Pulmonary Arterial Hypertension.

  2017cited by this paper
• Pattern of Congenital Heart Diseases and Treatment Options in a Bangladeshi Centre: Analysis of 6914 cases from Non-invasive Cardiac Laboratory

  2017cited by this paper
• [Congenital Heart Disease in Children with Down Syndrome: What Has Changed in the Last Three Decades?]

  2016cited by this paper
• Patients with Down syndrome and congenital heart disease: survival is improving, but challenges remain

  2016cited by this paper
• Prevalence of Noncardiac and Genetic Abnormalities in Neonates Undergoing Cardiac Operations: Analysis of The Society of Thoracic Surgeons Congenital Heart Surgery Database.

  2016cited by this paper
• Trends in Congenital Heart Defects in Infants With Down Syndrome

  2016cited by this paper
• Recent Advances in Pediatric Cardiopulmonary Bypass

  2014cited by this paper
• Surgical treatment of patent ductus arteriosus in adults.

  2011cited by this paper
• Prevalence of congenital heart defects and persistent pulmonary hypertension of the neonate with Down syndrome

  2010cited by this paper
• Moss and Adams' Heart Disease in Infants, Children and Adolescents: Including the Fetus and Young Adult—2 Volume Set

  2009cited by this paper
• Pathophysiology of Congenital Heart Disease in the Adult: Part I: Shunt Lesions

  2008cited by this paper
• Orphanet Journal of Rare Diseases BioMed Central Review Patent arterial duct

  2008cited by this paper
• Prevalence of congenital heart defects in children with Down’s syndrome in Imam Khomeini Hospital, Tehran

  2007cited by this paper
• Complete atrioventricular canal

  2006cited by this paper
• Cardiac problems in Down syndrome

  2004cited by this paper
• Treatment of atrial septal defects in symptomatic children aged less than 2 years of age using the Amplatzer septal occluder

  2000cited by this paper
• Unequal cardiac care for children with Down's syndrome.

  1985cited by this paper
• Catheter closure of patent ductus arteriosus. 62 cases treated without thoracotomy.

  1971cited by this paper
• Natural history of persistent ductus arteriosus.

  1968cited by this paper

• No citing papers are available for this paper.