ADF/cofilin promotes invadopodial membrane recycling during cell invasion in vivo

Localized F-actin disassembly by ADF/cofilin drives invadopodial membrane recycling through endolysosomes, which promotes efficient cell transmigration through the basement membrane.

• Publication year

  2014

• Venue

  Journal of Cell Biology

• Publication date

  2014-03-31

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1083/jcb.201312098PMID 24662568PMCID 3971745
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• The netrin receptor DCC focuses invadopodia-driven basement membrane transmigration in vivo

  2013influential reference
• Cofilin and Vangl2 cooperate in the initiation of planar cell polarity in the mouse embryo

  2013cited by this paper
• Laminins in basement membrane assembly

  2013cited by this paper
• Establishment and Validation of Computational Model for MT1-MMP Dependent ECM Degradation and Intervention Strategies

  2012cited by this paper
• N-WASP coordinates the delivery and F-actin–mediated capture of MT1-MMP at invasive pseudopods

  2012cited by this paper
• The 'ins' and 'outs' of podosomes and invadopodia: characteristics, formation and function

  2011cited by this paper
• Invadosomes: intriguing structures with promise.

  2011cited by this paper
• Cell invasion through basement membrane: the anchor cell breaches the barrier.

  2011cited by this paper
• Intravital microscopy: new insights into metastasis of tumors

  2011cited by this paper
• Endo-Lysosomal Vesicles Positive for Rab7 and LAMP1 Are Terminal Vesicles for the Transport of Dextran

  2011cited by this paper
• Dynamic membrane remodeling at invadopodia differentiates invadopodia from podosomes.

  2011cited by this paper
• ADF/cofilin regulates secretory cargo sorting at the TGN via the Ca2+ ATPase SPCA1.

  2011cited by this paper
• Roles of CUP-5, the Caenorhabditis elegans orthologue of human TRPML1, in lysosome and gut granule biogenesis

  2010cited by this paper
• Cancer dissemination--lessons from leukocytes.

  2010cited by this paper
• In Vivo Identification of Regulators of Cell Invasion Across Basement Membranes

  2010cited by this paper
• ADF/cofilin: a functional node in cell biology.

  2010cited by this paper
• Regulation of Acetylcholine Receptor Clustering by ADF/Cofilin-Directed Vesicular Trafficking

  2009cited by this paper
• Matrix invasion by tumour cells: a focus on MT1-MMP trafficking to invadopodia

  2009influential reference
• Actin remodeling by ADF/cofilin is required for cargo sorting at the trans-Golgi network

  2009cited by this paper
• Integrin acts upstream of netrin signaling to regulate formation of the anchor cell's invasive membrane in C. elegans.

  2009influential reference
• Relaxing the actin cytoskeleton for adhesion and movement with Ena/VASP

  2008cited by this paper
• Ins and outs of ADF/cofilin activity and regulation.

  2008influential reference
• UNC-6 (Netrin) Orients the Invasive Membrane of the Anchor Cell in C. elegans

  2008cited by this paper
• Arp2/3 complex interactions and actin network turnover in lamellipodia

  2008cited by this paper
• Breaching the basement membrane: who, when and how?

  2008cited by this paper
• Evaluating performance in three-dimensional fluorescence microscopy

  2007cited by this paper
• Cofilin recruitment and function during actin-mediated endocytosis dictated by actin nucleotide state

  2007cited by this paper
• Cofilin promotes stimulus-induced lamellipodium formation by generating an abundant supply of actin monomers

  2007cited by this paper
• The cofilin pathway in breast cancer invasion and metastasis

  2007cited by this paper
• Genome-wide analysis identifies a general requirement for polarity proteins in endocytic traffic

  2007cited by this paper
• BMC Genomics BioMed Central Methodology article TILLING is an effective reverse genetics technique for

  2006cited by this paper
• Engineering of a monomeric green-to-red photoactivatable fluorescent protein induced by blue light

  2006cited by this paper
• Mechanism of actin filament turnover by severing and nucleation at different concentrations of ADF/cofilin.

  2006cited by this paper
• A Role for Synaptotagmin VII-Regulated Exocytosis of Lysosomes in Neurite Outgrowth from Primary Sympathetic Neurons

  2006cited by this paper
• FOS-1 promotes basement-membrane removal during anchor-cell invasion in C. elegans.

  2005influential reference
• Molecular mechanisms of invadopodium formation

  2005cited by this paper
• The RNA-binding protein SUP-12 controls muscle-specific splicing of the ADF/cofilin pre-mRNA in C. elegans

  2004cited by this paper
• Actin-depolymerizing factor and cofilin-1 play overlapping roles in promoting rapid F-actin depolymerization in mammalian nonmuscle cells.

  2004cited by this paper
• Cofilin Promotes Actin Polymerization and Defines the Direction of Cell Motility

  2004cited by this paper
• Specific requirement for two ADF/cofilin isoforms in distinct actin-dependent processes in Caenorhabditis elegans

  2003cited by this paper
• Anchor cell invasion into the vulval epithelium in C. elegans.

  2003cited by this paper
• Intravital imaging of cell movement in tumours

  2003cited by this paper
• [C. elegans: of neurons and genes].

  2003cited by this paper
• Regulation of Growth Cone Actin Dynamics by ADF/Cofilin1

  2003cited by this paper
• Actin remodeling to facilitate membrane fusion.

  2003cited by this paper
• Dynamin participates in focal extracellular matrix degradation by invasive cells.

  2003cited by this paper
• Cofilin produces newly polymerized actin filaments that are preferred for dendritic nucleation by the Arp2/3 complex.

  2002cited by this paper
• Cofilin/ADF is required for cell motility during Drosophila ovary development and oogenesis

  2001cited by this paper
• Plasma membrane repair is mediated by Ca(2+)-regulated exocytosis of lysosomes.

  2001cited by this paper
• Control of Actin Dynamics in Cell Motility

  1999cited by this paper
• UNC-60B, an ADF/Cofilin Family Protein, Is Required for Proper Assembly of Actin into Myofibrils in Caenorhabditis elegans Body Wall Muscle

  1999cited by this paper
• The Caenorhabditis elegans unc-60 gene encodes proteins homologous to a family of actin-binding proteins

  1994cited by this paper
• Proteolytic activity of specialized surface protrusions formed at rosette contact sites of transformed cells.

  1989cited by this paper
• [Genetics of Caenorhabditis elegans].

  1989cited by this paper
• The genetics of Caenorhabditis elegans.

  1974cited by this paper
• Control of Actin Dynamics in Cell Motility

  year unknowninfluential reference

• The regenerative period of somatosensory nerves is closed by a DCC signaling axis

  2026cites this paper
• Repair and reconstruction of lower extremity defects with combined pedicled superficial circumflex iliac artery perforator flap.

  2025cites this paper
• Specialized high-capacity mitochondria fuel cell invasion

  2025cites this paper
• Research Advances in Vascular Remodeling in Choke Vessels of Perforator Flap

  2024cites this paper
• A role for organ level dynamics in morphogenesis of the C. elegans hermaphrodite distal tip cell

  2024cites this paper
• The C. elegans anchor cell: A model to elucidate mechanisms underlying invasion through basement membrane.

  2023cites this paper
• Localized glucose import, glycolytic processing, and mitochondria generate a focused ATP burst to power basement-membrane invasion.

  2022cites this paper
• Reciprocal EGFR signaling in the anchor cell ensures precise inter-organ connection during Caenorhabditis elegans vulval morphogenesis

  2022cites this paper
• The SWI/SNF chromatin remodeling assemblies BAF and PBAF differentially regulate cell cycle exit and cellular invasion in vivo

  2021cites this paper
• WTS-1/LATS regulates endocytic recycling by restraining F-actin assembly in a synergistic manner.

  2021cites this paper
• Reciprocal EGFR signaling in the Anchor Cell ensures precise inter-organ connection during C. elegans vulval morphogenesis

  2021cites this paper
• RTKN-1/Rhotekin shields endosome-associated F-actin from disassembly to ensure endocytic recycling

  2021cites this paper
• Integration of biochemical and topographic cues for the formation and spatial distribution of invadosomes in nasopharyngeal epithelial cells.

  2020cites this paper
• Liprin-α1 in cancer cell adhesion machinery and tumor progression

  2019cites this paper
• Cofilin-1 signaling mediates epithelial-mesenchymal transition by promoting actin cytoskeleton reorganization and cell-cell adhesion regulation in colorectal cancer cells.

  2019cites this paper
• Forces drive basement membrane invasion in Caenorhabditis elegans

  2018cites this paper
• LEBANESE AMERICAN UNIVERSITY Distinctive Roles of RhoA and RhoC in Glioma Cell Motility, Invasion, and Invadopodia assembly

  2018cites this paper
• PTRN‐1/CAMSAP promotes CYK‐1/formin‐dependent actin polymerization during endocytic recycling

  2018cites this paper
• Long-term C. elegans immobilization enables high resolution developmental studies in vivo.

  2018cites this paper
• Divide or Conquer: Cell Cycle Regulation of Invasive Behavior.

  2017cites this paper
• Rac3 regulates breast cancer invasion and metastasis by controlling adhesion and matrix degradation

  2017cites this paper
• Cytoskeleton-Associated Risk Modifiers Involved in Early and Rapid Progression of Sporadic Creutzfeldt-Jakob Disease

  2017cites this paper
• Live-cell confocal microscopy and quantitative 4D image analysis of anchor-cell invasion through the basement membrane in Caenorhabditis elegans

  2017cites this paper
• Glutaminolysis drives membrane trafficking to promote invasiveness of breast cancer cells

  2017cites this paper
• Cell Invasion In Vivo via Rapid Exocytosis of a Transient Lysosome-Derived Membrane Domain.

  2017cites this paper
• Breaching and Opening Basement Membrane Barriers: The Anchor Cell Leads the Way

  2017cites this paper
• Cytoskeleton Dynamics: Actin in Cell Invasion

  2017cites this paper
• Breaking down barriers: the evolution of cell invasion.

  2017cites this paper
• Invading, Leading and Navigating Cells in Caenorhabditis elegans: Insights into Cell Movement in Vivo

  2017cites this paper
• Rac3 regulates breast cancer invasion and metastasis by controlling adhesion and matrix degradation

  2017cites this paper
• Molecular Mechanisms of Assembly and Long-term Maintenance of Neuronal Architecture: A Dissertation

  2016cites this paper
• Invadosomes - shaping actin networks to follow mechanical cues.

  2016cites this paper
• SPARC Promotes Cell Invasion In Vivo by Decreasing Type IV Collagen Levels in the Basement Membrane

  2016cites this paper
• The microenvironment controls invadosome plasticity

  2016cites this paper
• A new front in cell invasion: The invadopodial membrane.

  2016cites this paper
• A Sensitized Screen for Genes Promoting Invadopodia Function In Vivo: CDC-42 and Rab GDI-1 Direct Distinct Aspects of Invadopodia Formation

  2016influential citation
• SPARC promotes cell invasion in vivo by decreasing type IV collagen levels in the basement membrane

  2016cites this paper
• LIMK Regulates Tumor-Cell Invasion and Matrix Degradation Through Tyrosine Phosphorylation of MT1-MMP

  2016cites this paper
• Advanced microscopy studies of invadosome rosettes

  2016cites this paper
• Le rétromère : une nouvelle cible des kinases Src dans le transport polarisé et l'invasion tumorale

  2015cites this paper
• MicroRNA-429 inhibits the migration and invasion of colon cancer cells by targeting PAK6/cofilin signaling.

  2015cites this paper
• An active role for basement membrane assembly and modification in tissue sculpting

  2015cites this paper
• Small GTPase Rab21 Mediates Fibronectin Induced Actin Reorganization in Entamoeba histolytica: Implications in Pathogen Invasion

  2015cites this paper
• Invasive Cell Fate Requires G1 Cell-Cycle Arrest and Histone Deacetylase-Mediated Changes in Gene Expression.

  2015cites this paper
• Brief Reports: Lysosomal Cross‐Correction by Hematopoietic Stem Cell‐Derived Macrophages Via Tunneling Nanotubes

  2015cites this paper
• Basement Membranes in the Worm: A Dynamic Scaffolding that Instructs Cellular Behaviors and Shapes Tissues.

  2015cites this paper
• Genome‐wide identification of miR‐200 targets reveals a regulatory network controlling cell invasion

  2014cites this paper
• The role of p21-activated kinases in melanoma progression

  2014cites this paper
• B-LINK: a hemicentin, plakin, and integrin-dependent adhesion system that links tissues by connecting adjacent basement membranes.

  2014cites this paper
• Podoplanin mediates ECM degradation by squamous carcinoma cells through control of invadopodia stability

  2014cites this paper