Chaperone-Assisted Protein Folding Is Critical for Yellow Fever Virus NS3/4A Cleavage and Replication

No abstract is available for this paper.

• Publication year

  2016

• Venue

  Journal of Virology

• Publication date

  2016-01-06

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1128/JVI.03077-15PMID 26739057PMCID PMC4810624
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Flaviviridae.

  2020cited by this paper
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  2015cited by this paper
• Characterization of the Determinants of NS2-3-Independent Virion Morphogenesis of Pestiviruses

  2015cited by this paper
• Crucial HSP70 co-chaperone complex unlocks metazoan protein disaggregation

  2015cited by this paper
• Defining Hsp70 Subnetworks in Dengue Virus Replication Reveals Key Vulnerability in Flavivirus Infection.

  2015influential reference
• A Nucleotide Exchange Factor Promotes Endoplasmic Reticulum-to-Cytosol Membrane Penetration of the Nonenveloped Virus Simian Virus 40

  2015cited by this paper
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  2015cited by this paper
• Glucocorticoid receptor function regulated by coordinated action of the Hsp90 and Hsp70 chaperone cycles.

  2014cited by this paper
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  2013cited by this paper
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  2013cited by this paper
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  2013cited by this paper
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  2013influential reference
• Cellular chaperones and folding enzymes are vital contributors to membrane bound replication and movement complexes during plant RNA virus infection

  2012cited by this paper
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  2012cited by this paper
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  2012cited by this paper
• Flavivirus Replication Complex Assembly Revealed by DNAJC14 Functional Mapping

  2012cited by this paper
• Pepino mosaic virus capsid protein interacts with a tomato heat shock protein cognate 70.

  2012cited by this paper
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  2011cited by this paper
• Biosynthesis of Classical Swine Fever Virus Nonstructural Proteins

  2011cited by this paper
• The HSP70 chaperone machinery: J proteins as drivers of functional specificity

  2010cited by this paper
• Viral interaction with molecular chaperones: role in regulating viral infection

  2010cited by this paper
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  2009cited by this paper
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  2009cited by this paper
• Heat shock protein 40: structural studies and their functional implications.

  2009cited by this paper
• A Key Role for Heat Shock Protein 70 in the Localization and Insertion of Tombusvirus Replication Proteins to Intracellular Membranes

  2009cited by this paper
• Influence of cytoplasmic heat shock protein 70 on viral infection of Nicotiana benthamiana.

  2008cited by this paper
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  2008cited by this paper
• Structural and functional diversities between members of the human HSPB, HSPH, HSPA, and DNAJ chaperone families.

  2008cited by this paper
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  2007cited by this paper
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  2007cited by this paper
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  2006cited by this paper
• Pathogenesis of West Nile Virus Infection: a Balance between Virulence, Innate and Adaptive Immunity, and Viral Evasion

  2006cited by this paper
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  2005cited by this paper
• Not all J domains are created equal: Implications for the specificity of Hsp40–Hsp70 interactions

  2005influential reference
• Construction and applications of yellow fever virus replicons.

  2005cited by this paper
• Hsp70 chaperones: Cellular functions and molecular mechanism

  2005cited by this paper
• Recruitment of Hsp70 chaperones: a crucial part of viral survival strategies.

  2005cited by this paper
• Effects of Calreticulin on Viral Cell-to-Cell Movement1

  2005cited by this paper
• Virus Induction of Heat Shock Protein 70 Reflects a General Response to Protein Accumulation in the Plant Cytosol1

  2005cited by this paper
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  2005cited by this paper
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  2005cited by this paper
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  2004cited by this paper
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  2004cited by this paper
• Quality control in the endoplasmic reticulum

  2003cited by this paper
• Mutation of Host dnaJ Homolog Inhibits Brome Mosaic Virus Negative-Strand RNA Synthesis

  2003cited by this paper
• Getting a grip on non‐native proteins

  2003cited by this paper
• A stable full-length yellow fever virus cDNA clone and the role of conserved RNA elements in flavivirus replication.

  2003cited by this paper
• Quality control in the endoplasmic reticulum protein factory

  2003cited by this paper
• Cell-Derived Sequences in the N-Terminal Region of the Polyprotein of a Cytopathogenic Pestivirus

  2003cited by this paper
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  2003cited by this paper
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  2003cited by this paper
• A polyaromatic caveolin-binding-like motif in the cytoplasmic tail of the type 1 receptor for angiotensin II plays an important role in receptor trafficking and signaling.

  2002cited by this paper
• Mutations in the Yellow Fever Virus Nonstructural Protein NS2A Selectively Block Production of Infectious Particles

  2002cited by this paper
• Chaperoning signaling pathways: molecular chaperones as stress-sensing 'heat shock' proteins.

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  2001cited by this paper
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  2001cited by this paper
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• Accessory proteins in the biogenesis of G protein-coupled receptors.

  2001cited by this paper
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  1999cited by this paper
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  1999cited by this paper
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  1999cited by this paper
• trans-Complementation of yellow fever virus NS1 reveals a role in early RNA replication

  1997cited by this paper
• The NH2-terminal 108 amino acids of the Escherichia coli DnaJ protein stimulate the ATPase activity of DnaK and are sufficient for lambda replication.

  1994cited by this paper
• Cleavage at a novel site in the NS4A region by the yellow fever virus NS2B-3 proteinase is a prerequisite for processing at the downstream 4A/4B signalase site

  1993cited by this paper
• Mutagenesis of conserved residues at the yellow fever virus 3/4A and 4B/5 dibasic cleavage sites: effects on cleavage efficiency and polyprotein processing.

  1993cited by this paper
• Proteolytic processing of a Murray Valley encephalitis virus non-structural polyprotein segment containing the viral proteinase: accumulation of a NS3-4A precursor which requires mature NS3 for efficient processing.

  1992cited by this paper
• Processing of the yellow fever virus nonstructural polyprotein: a catalytically active NS3 proteinase domain and NS2B are required for cleavages at dibasic sites

  1991cited by this paper
• Escherichia coli DnaJ and GrpE heat shock proteins jointly stimulate ATPase activity of DnaK.

  1991cited by this paper
• Production of yellow fever virus proteins in infected cells: identification of discrete polyprotein species and analysis of cleavage kinetics using region-specific polyclonal antisera.

  1990cited by this paper
• Yellow fever virus proteins NS2A, NS2B, and NS4B: identification and partial N-terminal amino acid sequence analysis.

  1989cited by this paper
• Eukaryotic transient-expression system based on recombinant vaccinia virus that synthesizes bacteriophage T7 RNA polymerase.

  1986cited by this paper

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  2022cites this paper
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  2021cites this paper
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  2019cites this paper
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  2019cites this paper
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  2019cites this paper
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  2018cites this paper
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  2018cites this paper
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