Ga-68 DOTATATE PET/CT in a patient with Zollinger-Ellison syndrome

This case report follows a 70-year-old male patient with Zollinger-Ellison syndrome undergoing computed tomography (CT) for weight loss and surveillance of bilateral adrenal nodules. Incidentally, diffuse gastric and duodenal wall thickening was noted on CT. The patient underwent esophagogastroduodenoscopy with biopsy results showing well-differentiated neuroendocrine tumors (NET) in the stomach and duodenum. Subsequent imaging with gallium-68 DOTATATE PET/CT showed intense tracer uptake in the stomach and proximal duodenum with liver and regional nodal metastases around the superior mesenteric artery. This case outlines the utility of Ga-68 DOTATATE PET/CT in diagnosing, localizing, and staging NET such as gastrinomas.

• Publication year

  2023

• Venue

  Radiology Case Reports

• Publication date

  2023-01-06

• Fields of study

  Medicine

• Identifiers
  DOI 10.1016/j.radcr.2022.12.038PMID 36684643PMCID 9849991
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

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• Multiple Endocrine Neoplasia: Spectrum of Abdominal Manifestations.

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  2012cited by this paper
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  2008cited by this paper
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