Differential blood-brain barrier breakdown and leucocyte recruitment following excitotoxic lesions in juvenile and adult rats.

No abstract is available for this paper.

• Publication year

  1998

• Venue

  Experimental Neurology

• Publication date

  1998-11-01

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1006/EXNR.1998.6927PMID 9875284
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Both apoptosis and necrosis occur following intrastriatal administration of excitotoxins

  2004cited by this paper
• Neurotoxicity of N-methyI-D-aspartate is markedly enhanced in developing rat central nervous system

  2002cited by this paper
• Interleukin‐1β and the interleukin‐1 receptor antagonist act in the striatum to modify excitotoxic brain damage in the rat

  1998cited by this paper
• Loss of the tight junction proteins occludin and zonula occludens-1 from cerebral vascular endothelium during neutrophil-induced blood-brain barrier breakdown in vivo.

  1998cited by this paper
• Morphological and immunophenotypic microglial changes in the denervated fascia dentata of adult rats: correlation with blood-brain barrier damage and astroglial reactions.

  1997cited by this paper
• Non‐NMDA and NMDA receptor‐mediated excitotoxic neuronal deaths in adult brain are morphologically distinct: Further evidence for an apoptosis‐necrosis continuum

  1997cited by this paper
• Neurotoxicity, blood-brain barrier breakdown, demyelination and remyelination associated with NMDA-induced lesions of the rat lateral hypothalamus.

  1997cited by this paper
• Age-related effects of interleukin-1 beta on polymorphonuclear neutrophil-dependent increases in blood-brain barrier permeability in rats.

  1997cited by this paper
• Excitotoxic neuronal death in the immature brain is an apoptosis‐necrosis morphological continuum

  1997cited by this paper
• The Role of Neutrophils in the Production of Hypoxic-Ischemic Brain Injury in the Neonatal Rat

  1997cited by this paper
• The blood-brain barrier and the inflammatory response.

  1997cited by this paper
• New therapeutic possibility of blocking cytokine-induced neutrophil chemoattractant on transient ischemic brain damage in rats.

  1997cited by this paper
• News on glutamate receptors in glial cells.

  1996cited by this paper
• Microglial response to N‐methyl‐D‐aspartate‐mediated excitotoxicity in the immature rat brain

  1996cited by this paper
• Overriding the brain's intrinsic resistance to leukocyte recruitment with intraparenchymal injections of recombinant chemokines.

  1996cited by this paper
• Apoptosis, oncosis, and necrosis. An overview of cell death.

  1995cited by this paper
• The Unique Characteristics of Inflammatory Responses in Mouse Brain are Acquired During Postnatal Development

  1995cited by this paper
• NMDA and Kainate Induce Internucleosomal DNA Cleavage Associated With Both Apoptotic and Necrotic Cell Death in the Neonatal Rat Brain

  1995cited by this paper
• Early and transient increase of rat hippocampal blood-brain barrier permeability to amino acids during kainic acid-induced seizures.

  1995cited by this paper
• Demyelination in the central nervous system following a delayed-type hypersensitivity response to bacillus Calmette-Guérin.

  1995cited by this paper
• Inflammation in the nervous system.

  1995cited by this paper
• Inflammatory leukocytic recruitment and diffuse neuronal degeneration are separate pathological processes resulting from traumatic brain injury

  1995cited by this paper
• Excitotoxin-induced neuronal degeneration and seizure are mediated by tissue plasminogen activator

  1995cited by this paper
• Experimental gliopathy in the adult rat CNS: Effect on the blood‐spinal cord barrier

  1994cited by this paper
• Death of neurons in the neonatal rodent and primate globus pallidus occurs by a mechanism of apoptosis.

  1994cited by this paper
• The acute inflammatory response to lipopolysaccharide in CNS parenchyma differs from that in other body tissues.

  1992cited by this paper
• Excitotoxic cell death.

  1992cited by this paper
• Permeability of bovine brain microvessel endothelial cells in vitro: barrier tightening by a factor released from astroglioma cells.

  1992cited by this paper
• Interleukin-1 receptor antagonist inhibits ischaemic and excitotoxic neuronal damage in the rat.

  1992cited by this paper
• Glial changes following an excitotoxic lesion in the CNS--I. Microglia/macrophages.

  1991cited by this paper
• The kinetics and morphological characteristics of the macrophage-microglial response to kainic acid-induced neuronal degeneration.

  1991cited by this paper
• The CNS acute inflammatory response to excitotoxic neuronal cell death.

  1991cited by this paper
• Glial changes following an excitotoxic lesion in the CNS--II. Astrocytes.

  1991cited by this paper
• An investigation into the early stages of the inflammatory response following ibotenic acid-induced neuronal degeneration.

  1990cited by this paper
• Tissue destruction by neutrophils.

  1989cited by this paper
• Neurotoxicity of N-methyl-D-aspartate is markedly enhanced in developing rat central nervous system.

  1988cited by this paper
• Astrocytes induce blood–brain barrier properties in endothelial cells

  1987cited by this paper
• Evidence for dendritic competition in the developing retina

  1982cited by this paper

• Role of N-methyl-d-aspartate receptors in anxiety disorder with thyroid lesions.

  2022cites this paper
• Tryptophan, kynurenine pathway, and diabetic ketoacidosis in type 1 diabetes

  2021cites this paper
• Cerebrospinal Fluid Pleocytosis Not Attributable to Status Epilepticus in First 24 Hours

  2021cites this paper
• Evaluating the safety profile of focused ultrasound and microbubble-mediated treatments to increase blood-brain barrier permeability

  2019cites this paper
• Pathology of Juvenile Animals

  2019cites this paper
• Astrocyte Activation and the Calcineurin/NFAT Pathway in Cerebrovascular Disease

  2018cites this paper
• Selective Vulnerability to Transcellular Pathway of Blood-Brain Barrier in Chronic Stage of the Kainate Model of Temporal Lobe Epilepsy in Rats

  2018cites this paper
• Markers of immune-mediated inflammation in the brains of young adults and adolescents with type 1 diabetes and fatal diabetic ketoacidosis. Is there a difference?

  2017cites this paper
• Migration of bone marrow progenitor cells in the adult brain of rats and rabbits.

  2016cites this paper
• Pyruvate blocks blood-brain barrier disruption, lymphocyte infiltration and immune response in excitotoxic brain injury.

  2016cites this paper
• Western diets induce blood-brain barrier leakage and alter spatial strategies in rats.

  2016cites this paper
• Cell-Type Specific Actions of Inflammatory Mediators in the CNS

  2016cites this paper
• Astroglia-Microglia Cross Talk during Neurodegeneration in the Rat Hippocampus

  2015cites this paper
• Nanoparticles for Brain Drug Delivery

  2015cites this paper
• The systemic response to CNS injury.

  2014cites this paper
• Translocator protein (18 kDa) mapping with [125I]-CLINDE in the quinolinic acid rat model of excitotoxicity: a longitudinal comparison with microglial activation, astrogliosis, and neuronal death.

  2014cites this paper
• Microglia, neuroinflammation, and beta-amyloid protein in Alzheimer's disease

  2014cites this paper
• The Brown University Traumatic Brain Injury Research Consortium and the Norman Prince Neurosciences Institute.

  2014cites this paper
• Translocator Protein (18 kDa) Mapping with [125I]-CLINDE in the Quinolinic Acid Rat Model of Excitotoxicity: A Longitudinal Comparison with Microglial Activation, Astrogliosis, and Neuronal Death

  2014cites this paper
• Paclitaxel‐induced neuropathic pain is age dependent and devolves on glial response

  2013cites this paper
• Caveolins and JNKs Influence Brain Endothelial Permeability after Juvenile TBI

  2013cites this paper
• Relationship between the chemokine receptor CCR5 and microglia in neurological disorders: consequences of targeting CCR5 on neuroinflammation, neuronal death and regeneration in a model of epilepsy.

  2013cites this paper
• N-3 FATTY ACIDS AND JUVENILE TRAUMATIC BRAIN INJURY: EFFECTS OF DIETARY N-3 FATTY ACID CONTENT, N-3 FATTY ACID STATUS, AND ORALLY DOSED FISH OIL ON SENSORIMOTOR AND BIOCHEMICAL OUTCOMES

  2013cites this paper
• Mast cell activation and neutrophil recruitment promotes early and robust inflammation in the meninges in EAE.

  2013cites this paper
• Nanoparticles for Brain Drug Delivery

  2013cites this paper
• Kynurenines and intestinal neurotransmission: the role of N-methyl-d-aspartate receptors

  2012cites this paper
• Copaiba Oil-Resin Treatment Is Neuroprotective and Reduces Neutrophil Recruitment and Microglia Activation after Motor Cortex Excitotoxic Injury

  2012cites this paper
• UNIVERSIDADE FEDERAL DO PARÁ INSTITUTO DE CIÊNCIAS BIOLÓGICAS PROGRAMA DE PÓS-GRADUAÇÃO EM NEUROCIÊNCIAS E BIOLOGIA CELULAR

  2012cites this paper
• Brain Resuscitation in the Drowning Victim

  2012cites this paper
• Spatiotemporal differences in vascular permeability after ischaemic brain damage

  2011cites this paper
• Immunohistological markers for proliferative events, gliogenesis, and neurogenesis within the adult hippocampus

  2011cites this paper
• Changes in nitric oxide content following injury to the neonatal rat brain.

  2011cites this paper
• Developing novel therapeutics for excitotoxic neuronal death following stroke

  2011cites this paper
• Sensorimotor behavioral tests for use in a juvenile rat model of traumatic brain injury: assessment of sex differences.

  2011cites this paper
• Immunohistological markers for proliferative events, gliogenesis, and neurogenesis within the adult hippocampus

  2011cites this paper
• Role of CCR5 and its ligands in the control of vascular inflammation and leukocyte recruitment required for acute excitotoxic seizure induction and neural damage

  2011cites this paper
• Roles of neural stem cells and adult neurogenesis in adolescent alcohol use disorders.

  2010cites this paper
• Intersection between metabolic dysfunction, high fat diet consumption, and brain aging

  2010cites this paper
• Minocycline treatment reduces white matter damage after excitotoxic striatal injury.

  2010cites this paper
• Adiponectin protects hippocampal neurons against kainic acid-induced excitotoxicity.

  2009cites this paper
• Evaluation of N‐benzyl‐N‐[11C]methyl‐2‐ (7‐methyl‐8‐oxo‐2‐phenyl‐7,8‐dihydro‐9H‐purin‐9‐yl)acetamide ([11C]DAC) as a novel translocator protein (18 kDa) radioligand in kainic acid‐lesioned rat

  2009cites this paper
• Imagerie moléculaire de la neuroinflammation : evaluation préclinique d'un nouveau radiopharmaceutique : le CLINDE.

  2009cites this paper
• Diffuse Axonal Damage, Myelin Impairment, Astrocytosis and Inflammatory Response Following Microinjections of NMDA into The Rat Striatum

  2008influential citation
• Nuclear imaging of neuroinflammation: a comprehensive review of [11C]PK11195 challengers

  2008cites this paper
• Acute Astrocyte Activation in Brain Detected by Mri: New Insights into T1 Hypointensity

  2008cites this paper
• Solutes, but not cells, drain from the brain parenchyma along basement membranes of capillaries and arteries: significance for cerebral amyloid angiopathy and neuroimmunology

  2008cites this paper
• Cadmium induces apoptotic cell death through p38 MAPK in brain microvessel endothelial cells.

  2008cites this paper
• Chronic hypoperfusion increases claudin-3 immunoreactivity in rat brain.

  2008cites this paper
• Impaired expression of excitatory amino acid transporter 2 (EAAT2) and glutamate homeostasis in canine necrotizing meningoencephalitis.

  2008cites this paper
• Inflammatory response and white matter damage after microinjections of endothelin-1 into the rat striatum.

  2008cites this paper
• Differential patterns of inflammatory response, axonal damage and myelin impairment following excitotoxic or ischemic damage to the trigeminal spinal nucleus of adult rats.

  2007cites this paper
• Differential Expression of Extracellular Matrix and Adhesion Molecule Genes in the Brain of Juvenile versus Adult Mice in Responses to Intracerebroventricular Administration of IL-1

  2007cites this paper
• Depletion of neutrophils reduces neuronal degeneration and inflammatory responses induced by quinolinic acid in vivo

  2007cites this paper
• Loss of the atypical inflammatory response in juvenile and aged rats

  2007cites this paper
• Immunohistological markers for staging neurogenesis in adult hippocampus

  2007cites this paper
• In vitro and ex vivo autoradiography studies on peripheral-type benzodiazepine receptor binding using [11C]AC-5216 in normal and kainic acid-lesioned rats.

  2007cites this paper
• Characterization of monocyte chemoattractant protein-1 expression following a kainate model of status epilepticus.

  2007cites this paper
• Immunohistological markers for staging neurogenesis in adult hippocampus.

  2007cites this paper
• Alterations in blood-brain barrier ICAM-1 expression and brain microglial activation after lambda-carrageenan-induced inflammatory pain.

  2006cites this paper
• Enhanced hippocampal neurodegeneration after traumatic or kainate excitotoxicity in GFAP-null mice.

  2006cites this paper
• Characterization of human monocyte‐derived microglia‐like cells

  2006cites this paper
• Brain Resuscitation in the Drowning Victim: Task Force on Brain Resuscitation

  2006cites this paper
• Age-related gadolinium-enhancement of MRI brain lesions in multiple sclerosis.

  2005cites this paper
• KINETICS OF NITRIC OXIDE RELEASE IN NEONATAL AND MATURE RAT BRAIN DURING ENDOTOXEMIA, AS STUDIED BY DIETHYLDITHIOCARBAMATE SPIN TRAPPING

  2005influential citation
• Systematic analysis of axonal damage and inflammatory response in different white matter tracts of acutely injured rat spinal cord.

  2005cites this paper
• Differential regulation of type I and type II interleukin‐1 receptors in focal brain inflammation

  2005cites this paper
• Blood-derived dendritic cells in an acute brain injury.

  2005cites this paper
• Role of inducible nitric oxide synthase in N-methyl-d-aspartic acid-induced strio-nigral degeneration.

  2004cites this paper
• Astrocytosis, microglia activation, oligodendrocyte degeneration, and pyknosis following acute spinal cord injury.

  2004cites this paper
• Using the immune system to target epilepsy.

  2004cites this paper
• Pain and the blood-brain barrier: obstacles to drug delivery.

  2003cites this paper
• Traumatic brain injury in infants and children: mechanisms of secondary damage and treatment in the intensive care unit.

  2003cites this paper
• The chemokine receptor CCR5 is not a necessary inflammatory mediator in kainic acid‐induced hippocampal injury: evidence for a compensatory effect by increased CCR2 and CCR3

  2003cites this paper
• Blood Genomic Expression Profile for Neuronal Injury

  2003cites this paper
• Altered chemokine expression in the spinal cord and brain contributes to differential interleukin‐1β‐induced neutrophil recruitment

  2002cites this paper
• Microvascular Cell Death in Spontaneously Hypertensive Rats During Experimental Inflammation

  2002cites this paper
• Systemic administration of kainic acid in adult rat stimulates expression of the chemokine receptor CCR5 in the forebrain

  2002cites this paper
• Expression of fractalkine (CX3CL1) and its receptor, CX3CR1, during acute and chronic inflammation in the rodent CNS

  2002cites this paper
• Molecular and Cellular Biology of Neuroprotection in the CNS

  2002cites this paper
• Main subunits of ionotropic glutamate receptors are expressed in isolated rat brain microvessels

  2002cites this paper
• Induction and activation of protein kinase C delta in hippocampus and cortex after kainic acid treatment.

  2002cites this paper
• Chemokines and Chemokine Receptors in Multiple Sclerosis: A Few Answers and Many More Questions

  2002cites this paper
• The Systemic and Local Acute Phase Response following Acute Brain Injury

  2002cites this paper
• Increased vulnerability to kainate‐induced seizures in utrophin‐knockout mice

  2002cites this paper
• Cellular and molecular determinants of glial scar formation.

  2002cites this paper
• Glutamate release promotes growth of malignant gliomas

  2001cites this paper
• Chemokine targets in acute brain injury and disease.

  2001cites this paper
• Cellular uptake and spread of the cell‐permeable peptide penetratin in adult rat brain

  2000cites this paper
• Novel Characteristics of Glutamate-Induced Cell Death in Primary Septohippocampal Cultures: Relationship to Calpain and Caspase-3 Protease Activation

  2000cites this paper
• Neurobiology of interleukin-1 receptors: getting the message.

  2000cites this paper
• Biochemical, cellular, and molecular mechanisms in the evolution of secondary damage after severe traumatic brain injury in infants and children: Lessons learned from the bedside

  2000cites this paper
• Neuroprotective strategies for basal ganglia degeneration: Parkinson's and Huntington's diseases.

  2000cites this paper
• Chemokine receptor antagonism as a new therapy for multiple sclerosis

  2000cites this paper
• Neuroglial activation repertoire in the injured brain: graded response, molecular mechanisms and cues to physiological function.

  1999cites this paper
• The therapeutic potential of CXC chemokine blockade in acute inflammation in the brain.

  1999cites this paper
• Neuronal Death and Blood–Brain Barrier Breakdown after Excitotoxic Injury Are Independent Processes

  1999influential citation