Temperature preconditioning of isolated rat hearts – a potent cardioprotective mechanism involving a reduction in oxidative stress and inhibition of the mitochondrial permeability transition pore

No abstract is available for this paper.

• Publication year

  2007

• Venue

  Journal of Physiology

• Publication date

  2007-06-01

• Fields of study

  Medicine, Chemistry

• Identifiers
  DOI 10.1113/jphysiol.2007.130369PMID 17395631PMCID PMC1976396
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Role of malonyl-CoA in heart disease and the hypothalamic control of obesity.

  2007cited by this paper
• K(ATP) channels and preconditioning: a re-examination of the role of mitochondrial K(ATP) channels and an overview of alternative mechanisms.

  2005influential reference
• Cardioprotection by ε-Protein Kinase C Activation From Ischemia

  2005cited by this paper
• Cardioprotection by epsilon-protein kinase C activation from ischemia: continuous delivery and antiarrhythmic effect of an epsilon-protein kinase C-activating peptide.

  2005cited by this paper
• Cardioprotection by &egr;-Protein Kinase C Activation From Ischemia: Continuous Delivery and Antiarrhythmic Effect of an &egr;-Protein Kinase C-Activating Peptide

  2005cited by this paper
• Diazoxide-induced respiratory inhibition – a putative mitochondrial KATP channel independent mechanism of pharmacological preconditioning

  2005cited by this paper
• AMP-activated protein kinase: a key stress signaling pathway in the heart.

  2005cited by this paper
• Lack of manifestations of diazoxide/5‐hydroxydecanoate‐sensitive KATP channel in rat brain nonsynaptosomal mitochondria

  2005cited by this paper
• AMP-activated protein kinase: ancient energy gauge provides clues to modern understanding of metabolism.

  2005influential reference
• Preconditioning protects by inhibiting the mitochondrial permeability transition.

  2004influential reference
• Evidence for Mitochondrial K Channels and Their Role in Cardioprotection

  2004cited by this paper
• Reduced reactive O2 species formation and preserved mitochondrial NADH and [Ca2+] levels during short-term 17 degrees C ischemia in intact hearts.

  2004influential reference
• Protein kinase activation and myocardial ischemia/reperfusion injury.

  2004cited by this paper
• Mitochondrial permeability transition pore opening during myocardial reperfusion--a target for cardioprotection.

  2004cited by this paper
• Hypothermia augments reactive oxygen species detected in the guinea pig isolated perfused heart.

  2004cited by this paper
• Ischemic preconditioning activates AMPK in a PKC-dependent manner and induces GLUT4 up-regulation in the late phase of cardioprotection.

  2004cited by this paper
• Pyruvate prevents cardiac dysfunction and AMP-activated protein kinase activation by hydrogen peroxide in isolated rat hearts.

  2004influential reference
• Reactive Oxygen Species Precede Protein Kinase C-&dgr; Activation Independent of Adenosine Triphosphate–sensitive Mitochondrial Channel Opening in Sevoflurane-induced Cardioprotection

  2004cited by this paper
• Nitric Oxide Synthase (NOS) Does Not Contribute to Simulated Ischaemic Preconditioning in an Isolated Rat Cardiomyocyte Model

  2004cited by this paper
• Apomorphine prevents myocardial ischemia/reperfusion-induced oxidative stress in the rat heart.

  2004influential reference
• Preconditioning improves postischemic mitochondrial function and diminishes oxidation of mitochondrial proteins.

  2004influential reference
• Transient Mitochondrial Permeability Transition Pore Opening Mediates Preconditioning-Induced Protection

  2004influential reference
• AMP-activated protein kinase mediates ischemic glucose uptake and prevents postischemic cardiac dysfunction, apoptosis, and injury.

  2004cited by this paper
• Hypothermic preconditioning induces rapid tolerance to focal ischemic injury in the rat.

  2003cited by this paper
• Mitochondrial KATP channels in preconditioning

  2003cited by this paper
• Ischemic preconditioning alters real-time measure of O2 radicals in intact hearts with ischemia and reperfusion.

  2003cited by this paper
• Ischaemic Preconditioning Inhibits Opening of Mitochondrial Permeability Transition Pores in the Reperfused Rat Heart

  2003influential reference
• Ischemic preconditioning promotes a transient, but not sustained translocation of protein kinase C and sensitization of adenylyl cyclase

  2003cited by this paper
• Matrix volume measurements challenge the existence of diazoxide/glibencamide‐sensitive KATP channels in rat mitochondria

  2003cited by this paper
• Mitochondrial K(ATP) channels in preconditioning.

  2003cited by this paper
• Mitochondrial potassium transport: the role of the mitochondrial ATP-sensitive K(+) channel in cardiac function and cardioprotection.

  2003cited by this paper
• Reactive Oxygen Species Precede the &egr; Isoform of Protein Kinase C in the Anesthetic Preconditioning Signaling Cascade

  2003cited by this paper
• The cardioprotective and mitochondrial depolarising properties of exogenous nitric oxide in mouse heart.

  2003cited by this paper
• Targeted disruption of the protein kinase C epsilon gene abolishes the infarct size reduction that follows ischaemic preconditioning of isolated buffer-perfused mouse hearts.

  2002cited by this paper
• Cardiac energy metabolism homeostasis: role of cytosolic calcium.

  2002cited by this paper
• The effects of ischaemic preconditioning, diazoxide and 5‐hydroxydecanoate on rat heart mitochondrial volume and respiration

  2002influential reference
• Formation of protein kinase C(epsilon)-Lck signaling modules confers cardioprotection.

  2002cited by this paper
• Expression of activated PKC epsilon (PKC epsilon) protects the ischemic heart, without attenuating ischemic H(+) production.

  2002cited by this paper
• Metabolic plasticity and the promotion of cardiac protection in ischemia and ischemic preconditioning.

  2002cited by this paper
• Expression of Activated PKC Epsilon (PKC ϵ) Protects the Ischemic Heart, without Attenuating Ischemic H+ Production

  2002cited by this paper
• Formation of protein kinase Cε-Lck signaling modules confers cardioprotection

  2002cited by this paper
• Opening of the Mitochondrial Permeability Transition Pore Causes Depletion of Mitochondrial and Cytosolic NAD+and Is a Causative Event in the Death of Myocytes in Postischemic Reperfusion of the Heart*

  2001cited by this paper
• Bioenergetic consequences of opening the ATP-sensitive K(+) channel of heart mitochondria.

  2001cited by this paper
• Cellular Energetics in the Preconditioned State

  2001cited by this paper
• Role of AMP-activated protein kinase in mechanism of metformin action.

  2001cited by this paper
• Actin is oxidized during myocardial ischemia.

  2001cited by this paper
• Adenosine monophosphate–activated protein kinase mediates the protective effects of ischemic preconditioning on hepatic ischemia‐reperfusion injury in the rat

  2001cited by this paper
• ATP-Sensitive potassium channels: a review of their cardioprotective pharmacology.

  2000cited by this paper
• Metabolic aspects of programmed cell survival and cell death in the heart.

  2000cited by this paper
• Reduced Cytosolic Ca2 Loading and Improved Cardiac Function After Cardioplegic Cold Storage of Guinea Pig Isolated Hearts

  2000cited by this paper
• Mechanisms whereby glucose deprivation triggers metabolic preconditioning in the isolated rat heart

  2000influential reference
• The Preconditioning Phenomenon A Tool for the Scientist or a Clinical Reality ?

  2000cited by this paper
• Cross bridge-dependent activation of contraction in cardiac myofibrils at low pH.

  1999cited by this paper
• Mibefradil, a T-Type and L-Type Calcium Channel Blocker, Limits Infarct Size through a Glibenclamide-Sensitive Mechanism

  1999influential reference
• Comparison of Intermittent Warm and Cold Blood Perfusion During Hypothermie Myocardial Preservation on Functional and Metabolic Recovery

  1999cited by this paper
• Modulation of myocardial function and [Ca2+] sensitivity by moderate hypothermia in guinea pig isolated hearts.

  1999cited by this paper
• Hypothermia preserves function and signaling for mitochondrial biogenesis during subsequent ischemia.

  1998cited by this paper
• Ischemic preconditioning of musculocutaneous flaps: effects of ischemia cycle length and number of cycles.

  1998cited by this paper
• Ca2+ as a mediator of ischemic preconditioning.

  1997cited by this paper
• Biochemistry and pathology of radical-mediated protein oxidation.

  1997cited by this paper
• Oxygen radicals released during ischemic preconditioning contribute to cardioprotection in the rabbit myocardium.

  1997influential reference
• Ischemic preconditioning induces selective translocation of protein kinase C isoforms epsilon and eta in the heart of conscious rabbits without subcellular redistribution of total protein kinase C activity.

  1997cited by this paper
• Paradoxical effect of ischemic preconditioning on ischemic contracture? NMR studies of energy metabolism and intracellular pH in the rat heart.

  1996cited by this paper
• Calcium preconditioning elicits strong protection against ischemic injury via protein kinase C signaling pathway.

  1996cited by this paper
• Is a high glycogen content beneficial or detrimental to the ischemic rat heart? A controversy resolved.

  1996cited by this paper
• Effect of ischemic preconditioning and PKC activation on acidification during ischemia in rat heart.

  1996cited by this paper
• Preconditioning of isolated rat heart is mediated by protein kinase C.

  1995cited by this paper
• Pronounced antiarrhythmic effects of ischemic preconditioning.

  1994cited by this paper
• Preconditioning of the heart by repeated stunning: attenuation of post-ischemic dysfunction

  1992cited by this paper
• Ischemic preconditioning protects against infarction in rat heart.

  1992cited by this paper
• Chelerythrine is a potent and specific inhibitor of protein kinase C.

  1990influential reference
• Determination of sixteen nucleotides, nucleosides and bases using high-performance liquid chromatography and its application to the study of purine metabolism in hearts for transplantation.

  1990cited by this paper
• Quantification of arrhythmias using scoring systems: an examination of seven scores in an in vivo model of regional myocardial ischaemia.

  1988cited by this paper
• The Lambeth Conventions: guidelines for the study of arrhythmias in ischaemia infarction, and reperfusion.

  1988cited by this paper
• Preconditioning with ischemia: a delay of lethal cell injury in ischemic myocardium.

  1986cited by this paper
• Comparison of Intermittent Warm and Cold Blood Perfusion During Hypothermic Myocardial Preservation on Functional and Metabolic Recovery

  1985cited by this paper

• Analysis of conditioning with dexmedetomidine under endothelial dysfunction in isolated perfused hearts

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• Preoperative consecutive treatment with isoprenaline and adenosine is safe and reduces ischaemia-reperfusion injury in a porcine model of cardiac surgery with recent acute myocardial infarction

  2025cites this paper
• Warm Cells, Hot Mitochondria: Achievements and Problems of Ultralocal Thermometry

  2023cites this paper
• Cardioprotection of Immature Heart by Simultaneous Activation of PKA and Epac: A Role for the Mitochondrial Permeability Transition Pore

  2022cites this paper
• The effect of hypothermia in a rat testicular torsion/detorsion model.

  2021cites this paper
• Preconditioning or Postconditioning with 8-Br-cAMP-AM Protects the Heart against Regional Ischemia and Reperfusion: A Role for Mitochondrial Permeability Transition

  2021cites this paper
• Mitochondrial Channels and their Role in Cardioprotection

  2021cites this paper
• Therapeutic hypothermia reduces inflammation and oxidative stress in the liver after asphyxial cardiac arrest in rats

  2020cites this paper
• The involvement of protein kinases in the cardioprotective effect of chronic hypoxia.

  2020cites this paper
• Myocardial Ischemia/Reperfusion injury: novel strategies for an old problem

  2020cites this paper
• Research Progress of the Application of Hypothermia in the Eye

  2020cites this paper
• Research Progress of the Application of Hypothermia in the Eye

  2020cites this paper
• Role of temperature in myocardial ischemic injury and protection by conditioning

  2020cites this paper
• Preconditioning-Like Properties of Short-Term Hypothermia in Isolated Perfused Rat Liver (IPRL) System

  2018cites this paper
• Consecutive Isoproterenol and Adenosine Treatment Confers Marked Protection against Reperfusion Injury in Adult but Not in Immature Heart: A Role for Glycogen

  2018cites this paper
• Pharmacological Targeting of the Mitochondrial Permeability Transition Pore for Cardioprotection

  2018cites this paper
• The role of succinate and ROS in reperfusion injury – A critical appraisal

  2017cites this paper
• Functional and cardioprotective effects of simultaneous and individual activation of protein kinase A and Epac

  2017influential citation
• Effect of mild hypothermia preconditioning against low temperature (4°C) induced rat liver cell injury in vitro

  2017cites this paper
• Mitochondrial Ca2+ and regulation of the permeability transition pore

  2017cites this paper
• The transcriptome responses of cardiomyocyte exposed to hypothermia.

  2016cites this paper
• Donor pretreatment with adenosine monophosphate-activated protein kinase activator protects cardiac grafts from cold ischaemia/reperfusion injury.

  2016cites this paper
• Ischemia reperfusion injury as a modifiable therapeutic target for cardioprotection or neuroprotection in patients undergoing cardiopulmonary resuscitation.

  2016cites this paper
• Hypothermia can reverse hepatic oxidative stress damage induced by hypoxia in rats

  2016cites this paper
• Hypoxia-reoxygenation differentially alters the thermal sensitivity of complex I basal and maximal mitochondrial oxidative capacity.

  2016cites this paper
• Combined effects of cadmium, hypoxia and temperature on mitochondrial bioenergetics in rainbow trout (Oncorhynchus mykiss)

  2016cites this paper
• Kardioprotektion beim herzchirurgischen Patienten

  2016cites this paper
• An inspection of therapeutic hypothermia preceding coronary reperfusion in patients with a cardiogenic shock complicating anterior ST-segment elevation myocardial infarction

  2015cites this paper
• Induction and Assessment of Ischemia-reperfusion Injury in Langendorff-perfused Rat Hearts.

  2015cites this paper
• Remote ischaemic preconditioning: is it a flag on the field?

  2015cites this paper
• The mitochondrial permeability transition: a current perspective on its identity and role in ischaemia/reperfusion injury.

  2015cites this paper
• Mitochondria-targeted ROS scavenger improves post-ischemic recovery of cardiac function and attenuates mitochondrial abnormalities in aged rats.

  2014cites this paper
• The effects of Trypanosoma brucei and mammalian-derived extracellular cathepsin-L on myocardial function

  2014cites this paper
• Myokardiale Protektion und Konditionierung

  2014cites this paper
• ESC Working Group Cellular Biology of the Heart: Position Paper: improving the preclinical assessment of novel cardioprotective therapies

  2014cites this paper
• Clinically-relevant consecutive treatment with isoproterenol and adenosine protects the failing heart against ischaemia and reperfusion

  2014cites this paper
• The role of hexokinase in cardioprotection – mechanism and potential for translation

  2014cites this paper
• Inhibition of JNK Aggravates the Recovery of Rat Hearts after Global Ischemia: The Role of Mitochondrial JNK

  2014cites this paper
• Effects of heat preconditioning on overload training induced myocardial injury.

  2013cites this paper
• The influence of age and type 2 diabetes on cardioprotective interventions against myocardial ischaemia-reperfusion injury.

  2013cites this paper
• Pre-conditioning with synthetic CpG-oligonucleotides attenuates myocardial ischemia/reperfusion injury via IL-10 up-regulation

  2013cites this paper
• Oxidative Stress and Antioxidant Activity in Hypothermia and Rewarming: Can RONS Modulate the Beneficial Effects of Therapeutic Hypothermia?

  2013cites this paper
• Deep hypothermia protects against acute hypoxia in vivo in rats: a mechanism related to the attenuation of oxidative stress

  2013cites this paper
• Urocortin 2 autocrine/paracrine and pharmacologic effects to activate AMP-activated protein kinase in the heart

  2013cites this paper
• Genetic Deletion of Catalytic Subunits of AMP-activated Protein Kinase Increases Osteoclasts and Reduces Bone Mass in Young Adult Mice*

  2013influential citation
• Etude de la ventilation liquide totale hypothermisante sur le syndrome post-arrêt cardiaque chez le lapin

  2013cites this paper
• Extent of Mitochondrial Hexokinase II Dissociation During Ischemia Correlates With Mitochondrial Cytochrome c Release, Reactive Oxygen Species Production, and Infarct Size on Reperfusion

  2012cites this paper
• Mitochondrial ROS production and subsequent ERK phosphorylation are necessary for temperature preconditioning of isolated ventricular myocytes

  2012influential citation
• Age-related changes in AMP-activated protein kinase after stroke

  2012cites this paper
• The Effects of Decreased Cardiac CapZ Protein on the Myocardial Response to Stress

  2012cites this paper
• Taxol, a microtubule stabilizer, improves cardiac functional recovery during postischemic reperfusion in rat in vitro.

  2012cites this paper
• Myocardial protection with mild hypothermia.

  2012cites this paper
• Etude des mécanismes contribuant aux effets des variations de l'apport en précurseurs de méthyles sur le protéome cardiaque

  2012cites this paper
• Activation of adenosine-monophosphate-activated protein kinase abolishes desflurane-induced preconditioning against myocardial infarction in vivo.

  2011cites this paper
• In vivo hyperoxic preconditioning protects against rat-heart ischemia/reperfusion injury by inhibiting mitochondrial permeability transition pore opening and cytochrome c release.

  2011cites this paper
• Temperature preconditioning is optimal at 26°C and confers additional protection to hypothermic cardioplegic ischemic arrest

  2011cites this paper
• Cold-impaired cardiac performance in rats is only partially overcome by cold acclimation

  2011cites this paper
• Phenylephrine preconditioning involves modulation of cardiac sarcolemmal K(ATP) current by PKC delta, AMPK and p38 MAPK.

  2011cites this paper
• The role of oxidized cytochrome c in regulating mitochondrial reactive oxygen species production and its perturbation in ischaemia

  2011cites this paper
• A small molecule AMPK activator protects the heart against ischemia-reperfusion injury.

  2011cites this paper
• Retrograde heart perfusion: the Langendorff technique of isolated heart perfusion.

  2011cites this paper
• Investigating the Effect of Antioxidant Treatment on the Protective Effect of Preconditioning in Anesthetized Rabbits

  2011cites this paper
• A Review of Mild Hypothermia as an Adjunctive Treatment for ST-Elevation Myocardial Infarction

  2011cites this paper
• Involvement of adenosine monophosphate-activated protein kinase in morphine-induced cardioprotection.

  2011cites this paper
• Post-Stroke Hypothermia Provides Neuroprotection through Inhibition of AMP-Activated Protein Kinase

  2011cites this paper
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  2010cites this paper
• Cardiac survival strategies: an evolutionary hypothesis with rationale for metabolic therapy of acute heart failure

  2010cites this paper
• A pore way to die: the role of mitochondria in reperfusion injury and cardioprotection.

  2010cites this paper
• 4′-Chlorodiazepam, a translocator protein (18 kDa) antagonist, improves cardiac functional recovery during postischemia reperfusion in rats

  2010cites this paper
• Alterations in gene expression after induction of profound hypothermia for the treatment of lethal hemorrhage.

  2010cites this paper
• The small chill: mild hypothermia for cardioprotection?

  2010cites this paper
• Hypothermic protection in an acute hypoxia model in rats: Acid-base and oxidant/antioxidant profiles.

  2010cites this paper
• Redox Control of Protein Kinase C: Cell- and Disease-Specific Aspects

  2010cites this paper
• Consecutive pharmacological activation of PKA and PKC mimics the potent cardioprotection of temperature preconditioning

  2010influential citation
• Rapid cooling preserves the ischaemic myocardium against mitochondrial damage and left ventricular dysfunction.

  2009cites this paper
• The role of the mitochondrial permeability transition pore in heart disease.

  2009cites this paper
• Post‐ischaemic activation of kinases in the pre‐conditioning‐like cardioprotective effect of the platelet‐activating factor

  2009cites this paper
• Mitochondria and reperfusion injury of the heart—A holey death but not beyond salvation

  2009influential citation
• Reactive Oxygen Species–Induced Stimulation of 5′AMP-Activated Protein Kinase Mediates Sevoflurane-Induced Cardioprotection

  2009cites this paper
• Myocardial hypothermia preserves mitochondrial and post-ischemic regional left ventricular functions in rabbits

  2009cites this paper
• Profound hypothermia decreases cardiac apoptosis through Akt survival pathway.

  2009cites this paper
• What is the mitochondrial permeability transition pore?

  2009cites this paper
• Antiapoptotic cardioprotective effect of hypothermia treatment against oxidative stress injuries.

  2009cites this paper
• Hypothermic preconditioning of endothelial cells attenuates cold-induced injury by a ferritin-dependent process.

  2009cites this paper
• Mitochondrial Permeability Transition Pore Opening as a Promising Therapeutic Target in Cardiac Diseases

  2009cites this paper
• Digital Comprehensive Summaries of Uppsala Dissertations from the Faculty of Medicine 422 Aspects of Induced Hypothermia following Cardiopulmonary Resuscitation Cerebral and Cardiovascular Effects

  2009cites this paper
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  2009cites this paper
• Inflammatory response and cardioprotection during open‐heart surgery: the importance of anaesthetics

  2008cites this paper
• Postconditioning the isolated perfused rat heart : the role of kinases and phosphatases

  2008cites this paper
• Inhibition of Mitochondrial Permeability Transition Pore Opening by Ischemic Preconditioning Is Probably Mediated by Reduction of Oxidative Stress Rather Than Mitochondrial Protein Phosphorylation

  2008cites this paper
• The role of mitochondria in protection of the heart by preconditioning

  2007cites this paper
• Temperature preconditioning: a cold‐hearted answer to ischaemic–reperfusion injury?

  2007influential citation
• Protein kinase C as a stress sensor.

  2007cites this paper
• Coronary artery disease progression is associated with increased resistance of hearts and myocytes to cardiac insults*

  2007cites this paper