[Role of the kidney in salt sensitive hypertension].

An important proportion of patients with essential hypertension are salt sensitive, defined as those who experience significant blood pressure changes according to the amount of salt intake. They have a disturbance in the pressure induced natriuresis mechanism and their kidneys have functional and morphological alterations consistent with an acquired tubulointerstitial alteration, afferent arteriole damage and alteration of peritubular capillaries. All these alterations lead to disturbances in sodium load excretion under normal pressures. There is also an associated activation of kidney vasoconstrictor/salt retaining systems and a reduction in the vasodilator/salt eliminating mechanisms. These alterations, that originate early in life, generate a new blood pressure level, that corrects natriuresis at the expense of a sustained hypertension.

• Publication year

  2010

• Venue

  Revista médica de Chile (Impresa)

• Publication date

  2010-07-01

• Fields of study

  Medicine, Chemistry

• Identifiers
  DOI 10.4067/S0034-98872010000700012PMID 21043083
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

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