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Role of Pfs47 in the dispersal of ancestral Plasmodium falciparum malaria through adaptation to different anopheline vectors

Alvaro Molina-Cruz,G. Canepa,Ankit Dwivedi,Weimin Liu,Nadia Raytselis,C. Antonio-Nkondjio,B. Hahn,Joana C. Silva,C. Barillas-Mury

Published 2023 in Proceedings of the National Academy of Sciences of the United States of America

ABSTRACT

Significance Plasmodium falciparum malaria remains a devastating parasitic disease with high morbidity and mortality. This disease originated in sylvatic regions of Africa from the transfer P. praefalciparum, a malaria parasite that infects gorillas, to humans. Human infections were likely initiated by bites from infected sylvan mosquitoes, but once the parasite adapted to humans, global dispersal of ancestral P. falciparum also required adaptation to different anopheline species present in new geographic regions. Here, we explore the extent to which parasite selection by the mosquito immune system was an important barrier for early dispersal of ancestral P. falciparum from sylvatic regions in Central Africa to other Sub-Saharan regions and to the Asian continent.

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