Long-lived crowded-litter mice exhibit lasting effects on insulin sensitivity and energy homeostasis.

No abstract is available for this paper.

• Publication year

  2014

• Venue

  American Journal of Physiology. Endocrinology and Metabolism

• Publication date

  2014-06-01

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1152/ajpendo.00031.2014PMID 24735888PMCID PMC4042097
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

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  2012cited by this paper
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  2012cited by this paper
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  2011cited by this paper
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  2011cited by this paper
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  2010cited by this paper
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  2009cited by this paper
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  2009cited by this paper
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  2009cited by this paper
• Life-span extension in mice by preweaning food restriction and by methionine restriction in middle age.

  2009influential reference
• Sex Differences in the Expression of Hepatic Drug Metabolizing Enzymes

  2009cited by this paper
• Caloric Restriction Delays Disease Onset and Mortality in Rhesus Monkeys

  2009cited by this paper
• Impact of reduced insulin‐like growth factor‐1/insulin signaling on aging in mammals: novel findings

  2008cited by this paper
• Insulin and aging

  2008influential reference
• Functionally significant insulin-like growth factor I receptor mutations in centenarians

  2008cited by this paper
• Insulin-like signaling, nutrient homeostasis, and life span.

  2008cited by this paper
• Insulin signaling cascade in the hearts of long-lived growth hormone receptor knockout mice: effects of calorie restriction.

  2008cited by this paper
• Aging and survival: the genetics of life span extension by dietary restriction.

  2008cited by this paper
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  2008cited by this paper
• Regulation of β‐cell mass and function by the Akt/protein kinase B signalling pathway

  2007cited by this paper
• Calorie restriction in nonhuman primates: assessing effects on brain and behavioral aging.

  2007cited by this paper
• Long-term effects of nutritional programming of the embryo and fetus: mechanisms and critical windows.

  2007cited by this paper
• Modelling the developmental origins of health and disease in the early embryo.

  2007cited by this paper
• Brain IRS2 Signaling Coordinates Life Span and Nutrient Homeostasis

  2007cited by this paper
• Lipids in Health and Disease

  2006cited by this paper
• Calorie restriction mimetics: an emerging research field

  2006cited by this paper
• Targeted disruption of growth hormone receptor interferes with the beneficial actions of calorie restriction

  2006cited by this paper
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  2006cited by this paper
• Long-lived growth hormone receptor knockout mice show a delay in age-related changes of body composition and bone characteristics.

  2006cited by this paper
• Caloric restriction and intermittent fasting: two potential diets for successful brain aging.

  2006cited by this paper
• Longevity genes: from primitive organisms to humans.

  2005cited by this paper
• Rapid and reversible induction of the longevity, anticancer and genomic effects of caloric restriction.

  2005cited by this paper
• Long-lived growth hormone receptor knockout mice: interaction of reduced insulin-like growth factor i/insulin signaling and caloric restriction.

  2005cited by this paper
• Overview of caloric restriction and ageing.

  2005cited by this paper
• Beta-cell secretory dysfunction in the pathogenesis of low birth weight-associated diabetes: a murine model.

  2005cited by this paper
• Insulin resistance: sex matters

  2005cited by this paper
• Hormone-treated snell dwarf mice regain fertility but remain long lived and disease resistant.

  2004cited by this paper
• Disruption of growth hormone receptor gene causes diminished pancreatic islet size and increased insulin sensitivity in mice.

  2004cited by this paper
• Long-term calorie restriction is highly effective in reducing the risk for atherosclerosis in humans.

  2004cited by this paper
• The paradox of the insulin/IGF-1 signaling pathway in longevity.

  2004cited by this paper
• Life extension in the dwarf mouse.

  2004cited by this paper
• Lifespan: Catch-up growth and obesity in male mice

  2004cited by this paper
• Longevity genes: from primitive organisms to humans.

  2003cited by this paper
• Adipokines, inflammation, and the endothelium in diabetes

  2003cited by this paper
• The dwarf mutation decreases high dose insulin responses in skeletal muscle, the opposite of effects in liver.

  2003cited by this paper
• Hyperglycemia induces PAI-1 gene expression in adipose tissue by activation of the hexosamine biosynthetic pathway.

  2002cited by this paper
• Adipogenesis and aging: does aging make fat go MAD?

  2002cited by this paper
• Longer Life Spans and Delayed Maturation in Wild-Derived Mice

  2002cited by this paper
• Effects of growth hormone and insulin-like growth factor 1 deficiency on ageing and longevity.

  2002cited by this paper
• New paradigms for research on aging and late-life illness.

  2001cited by this paper
• Peroxisome proliferator-activated receptor gamma ligands inhibit development of atherosclerosis in LDL receptor-deficient mice.

  2000cited by this paper
• Peroxisome proliferator–activated receptor γ ligands inhibit development of atherosclerosis in LDL receptor–deficient mice

  2000cited by this paper
• Effect of dietary fat on the development of non-insulin dependent diabetes mellitus in obese Zucker diabetic fatty male and female rats.

  2000cited by this paper
• Announcement: four-way cross mouse stocks: a new, genetically heterogeneous resource for aging research.

  1999cited by this paper
• Continuous Subcutaneous Insulin Infusion

  1997cited by this paper
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  1997cited by this paper
• Mutation of the mouse klotho gene leads to a syndrome resembling ageing

  1997cited by this paper
• Altered muscle insulin sensitivity in the male offspring of protein-malnourished rats.

  1996cited by this paper
• Number and size of islets of Langerhans in pregnant, human growth hormone-expressing transgenic, and pituitary dwarf mice: effect of lactogenic hormones.

  1995cited by this paper
• Effect of Acarbose on Carbohydrate and Lipid Metabolism in NIDDM Patients Poorly Controlled by Sulfonylureas

  1990cited by this paper
• Nutritional influences on aging of Fischer 344 rats: I. Physical, metabolic, and longevity characteristics.

  1985cited by this paper
• Defect of human growth hormone receptors in the liver of two patients with Laron-type dwarfism.

  1984cited by this paper
• The effect of dietary restriction of varying duration on survival, tumor patterns, immune function, and body temperature in B10C3F1 female mice.

  1983cited by this paper
• Glucose Intolerance and Aging

  1981cited by this paper
• Influence of controlled dietary restriction on immunologic function and aging.

  1979cited by this paper
• Pituitary dwarfism with high serum levels of growth hormone.

  1968cited by this paper
• The FASEB Journal • Research Communication Evidence for lifespan extension and delayed age-related biomarkers in insulin receptor substrate 1 null mice

  year unknowncited by this paper

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  2022cites this paper
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  2020cites this paper
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  2018cites this paper
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  2018cites this paper
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  2016cites this paper
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  2016cites this paper
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  2016cites this paper
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  2016cites this paper
• Nutritional limitation in early postnatal life and its effect on aging and longevity in rodents.

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  2016cites this paper
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