Cells activated for wound repair have the potential to direct collective invasion of an epithelium

Studies using a clinically relevant injury invasion model reveal that cells critical to wound repair are inherently invasive, acting as leaders to direct the collective invasion of a wounded epithelium. This model is a valuable tool with which to study leader cell–directed invasion and help understand how mechanisms of wound healing are hijacked to cause disease.

• Publication year

  2016

• Venue

  Molecular Biology of the Cell

• Publication date

  2016-02-01

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1091/mbc.E15-09-0615PMID 26658613PMCID 4751597
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Historical perspective of matrix metalloproteases.

  2015cited by this paper
• Dynamic tensile forces drive collective cell migration through three-dimensional extracellular matrices

  2015influential reference
• Establishment of a Clinically Relevant Ex Vivo Mock Cataract Surgery Model for Investigating Epithelial Wound Repair in a Native Microenvironment.

  2015cited by this paper
• Interactions between Hyaluronan and Its Receptors (CD44, RHAMM) Regulate the Activities of Inflammation and Cancer

  2015cited by this paper
• Modes of cancer cell invasion and the role of the microenvironment.

  2015cited by this paper
• Coupling between acto-adhesive machinery and ECM degradation in invadosomes

  2014cited by this paper
• The wound healing, chronic fibrosis, and cancer progression triad.

  2014cited by this paper
• Cdc42 and Tks5

  2014cited by this paper
• A central role for vimentin in regulating repair function during healing of the lens epithelium

  2014influential reference
• Post-translational modifications of intermediate filament proteins: mechanisms and functions

  2014cited by this paper
• Vimentin intermediate filament and plectin provide a scaffold for invadopodia, facilitating cancer cell invasion and extravasation for metastasis.

  2014cited by this paper
• Classifying collective cancer cell invasion

  2012cited by this paper
• Invadosomes: intriguing structures with promise.

  2011influential reference
• Degrading devices: invadosomes in proteolytic cell invasion.

  2011influential reference
• Trailblazing LIM kinases take the lead in collective tumor cell invasion

  2011cited by this paper
• Unique precursors for the mesenchymal cells involved in injury response and fibrosis

  2010influential reference
• Carcinoma-associated fibroblasts are a rate-limiting determinant for tumour progression

  2010cited by this paper
• LIM kinases are required for invasive path generation by tumor and tumor-associated stromal cells

  2010cited by this paper
• Actin, microtubules, and vimentin intermediate filaments cooperate for elongation of invadopodia

  2010cited by this paper
• Determinants of leader cells in collective cell migration.

  2010cited by this paper
• Follow the leader: LIM kinases pave the way for collective tumor cell invasion

  2010cited by this paper
• Invadosomes at a glance

  2009cited by this paper
• CD4(+) T cells regulate pulmonary metastasis of mammary carcinomas by enhancing protumor properties of macrophages.

  2009cited by this paper
• Overexpression of vimentin contributes to prostate cancer invasion and metastasis via src regulation.

  2008cited by this paper
• Collective invasion of carcinoma cells

  2008cited by this paper
• A role for the podosome/invadopodia scaffold protein Tks5 in tumor growth in vivo.

  2008cited by this paper
• Multiple regulatory inputs converge on cortactin to control invadopodia biogenesis and extracellular matrix degradation

  2008cited by this paper
• Cancer as an overhealing wound: an old hypothesis revisited

  2008cited by this paper
• Leading the charge

  2007cited by this paper
• The matrix corroded: podosomes and invadopodia in extracellular matrix degradation.

  2007influential reference
• Novel functions of vimentin in cell adhesion, migration, and signaling.

  2007cited by this paper
• Activation of SRC kinases signals induction of posterior capsule opacification.

  2007cited by this paper
• Cortactin is an essential regulator of matrix metalloproteinase secretion and extracellular matrix degradation in invadopodia.

  2007cited by this paper
• Role of phosphorylation on the structural dynamics and function of types III and IV intermediate filaments.

  2007cited by this paper
• Fibroblast-led collective invasion of carcinoma cells with differing roles for RhoGTPases in leading and following cells

  2007cited by this paper
• Multi-step pericellular proteolysis controls the transition from individual to collective cancer cell invasion

  2007cited by this paper
• Cancers as wounds that do not heal: differences and similarities between renal regeneration/repair and renal cell carcinoma.

  2006cited by this paper
• Dynamic interactions of cortactin and membrane type 1 matrix metalloproteinase at invadopodia: defining the stages of invadopodia formation and function.

  2006cited by this paper
• Macrophages: obligate partners for tumor cell migration, invasion, and metastasis.

  2006cited by this paper
• Regulatory mechanisms and functions of intermediate filaments: A study using site‐ and phosphorylation state‐specific antibodies

  2006cited by this paper
• Fibroblasts in cancer

  2006influential reference
• Stromal Fibroblasts in Cancer: A Novel Tumor-Promoting Cell Type

  2006cited by this paper
• Robustness, scalability, and integration of a wound-response gene expression signature in predicting breast cancer survival.

  2005cited by this paper
• CD44 attenuates metastatic invasion during breast cancer progression.

  2005cited by this paper
• The SRC substrate Tks5, podosomes (invadopodia), and cancer cell invasion.

  2005influential reference
• Gene Expression Signature of Fibroblast Serum Response Predicts Human Cancer Progression: Similarities between Tumors and Wounds

  2004cited by this paper
• Overexpression of vimentin: role in the invasive phenotype in an androgen-independent model of prostate cancer.

  2003cited by this paper
• Podosomes: adhesion hot-spots of invasive cells.

  2003cited by this paper
• Tumour-cell invasion and migration: diversity and escape mechanisms

  2003cited by this paper
• Laser capture microdissection-based in vivo genomic profiling of wound keratinocytes identifies similarities and differences to squamous cell carcinoma

  2003cited by this paper
• Tumor-Associated Macrophages in Breast Cancer

  2002cited by this paper
• Inflammation and cancer

  2002cited by this paper
• Inflammation and cancer: back to Virchow?

  2001cited by this paper
• Microenvironmental influence on macrophage regulation of angiogenesis in wounds and malignant tumors

  2001cited by this paper
• An invasion-related complex of cortactin, paxillin and PKCμ associates with invadopodia at sites of extracellular matrix degradation

  1999cited by this paper
• alpha6 Integrin is regulated with lens cell differentiation by linkage to the cytoskeleton and isoform switching.

  1999cited by this paper
• Cellular changes involved in conversion of normal to malignant breast: importance of the stromal reaction.

  1996cited by this paper
• VIMENTIN EXPRESSION IN CERVICAL CARCINOMAS: ASSOCIATION WITH INVASIVE AND MIGRATORY POTENTIAL

  1996cited by this paper
• Immunohistochemical evidence that human pterygia originate from an invasion of vimentin-expressing altered limbal epithelial basal cells.

  1994cited by this paper
• Increased expression of cytokeratins 8, 18 and vimentin in the invasion front of mucosal squamous cell carcinoma

  1993cited by this paper
• CD44H regulates tumor cell migration on hyaluronate-coated substrate

  1992cited by this paper
• Association of increased basement membrane invasiveness with absence of estrogen receptor and expression of vimentin in human breast cancer cell lines

  1992cited by this paper
• Tumors: wounds that do not heal. Similarities between tumor stroma generation and wound healing.

  1986cited by this paper
• [Inflammation and cancer].

  1974cited by this paper

• Differential Impacts on Proteoglycan Expression in the Response to Lens Wounding in Reparative and Pro‐Fibrotic Microenvironments

  2025cites this paper
• Vimentin - Force regulator in confined environments.

  2025cites this paper
• Supervised Machine-Based Learning and Computational Analysis to Reveal Unique Molecular Signatures Associated with Wound Healing and Fibrotic Outcomes to Lens Injury

  2025cites this paper
• Spiroconjugated 1,2,3-triazolo[5,1-b]1,3,4-thiadiazine stimulates functional activity of fibroblasts under skin injury regeneration

  2024cites this paper
• Changes in nascent chromatin structure regulate activation of the pro-fibrotic transcriptome and myofibroblast emergence in organ fibrosis

  2023cites this paper
• Immune Responses Induced at One Hour Post Cataract Surgery Wounding of the Chick Lens

  2023cites this paper
• Vimentin at the core of wound healing.

  2023cites this paper
• The Pro-Fibrotic Response to Lens Injury Is Signaled in a PI3K Isoform-Specific Manner

  2022cites this paper
• Microstructure-based engineering of soft biological materials

  2022cites this paper
• The Pro-fibrotic Response of Mesenchymal Leader Cells to Lens Wounding Involves Hyaluronic Acid, Its Receptor RHAMM, and Vimentin

  2022cites this paper
• Impact of Vimentin on Regulation of Cell Signaling and Matrix Remodeling

  2022cites this paper
• Vimentin Cytoskeleton Architecture Analysis on Polylactide and Polyhydroxyoctanoate Substrates for Cell Culturing

  2021cites this paper
• Resident immune cells of the avascular lens: Mediators of the injury and fibrotic response of the lens

  2021cites this paper
• The promising pro-healing role of the association of mesoglycan and lactoferrin on skin lesions.

  2021cites this paper
• The local wound environment is a key determinant of the outcome of TGFβ signaling on the fibrotic response of CD44+ leader cells in an ex vivo post-cataract-surgery model.

  2021cites this paper
• Fibronectin-based nanomechanical biosensors to map 3D surface strains in live cells and tissue

  2020cites this paper
• DeepScratch: Single-cell based topological metrics of scratch wound assays

  2020cites this paper
• What makes leader cells arise: Intrinsic properties and support from neighboring cells

  2020cites this paper
• yFibronectin-Based Nanomechanical Biosensors to Map 3D Strains in Live Cells and Tissues

  2020cites this paper
• Fibrosis: Shared Lessons From the Lens and Cornea

  2019influential citation
• Calcium Oscillatory Behavior and Its Possible Role during Wound Healing in Bovine Corneal Endothelial Cells in Culture

  2019cites this paper
• The role of focal adhesion kinase in transforming growth factor-β2 induced migration of human lens epithelial cells.

  2018cites this paper
• In wound repair vimentin mediates the transition of mesenchymal leader cells to a myofibroblast phenotype

  2018influential citation
• Cytokeratin-14 contributes to collective invasion of salivary adenoid cystic carcinoma

  2017cites this paper
• Wound repair: a showcase for cell plasticity and migration.

  2016cites this paper