Microtubule-stabilizing properties of the avocado-derived toxins (+)-(R)-persin and (+)-(R)-tetrahydropersin in cancer cells and activity of related synthetic analogs

No abstract is available for this paper.

• Publication year

  2016

• Venue

  Investigational new drugs

• Publication date

  2016-03-12

• Fields of study

  Medicine, Chemistry

• Identifiers
  DOI 10.1007/s10637-016-0341-zPMID 26968704
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• A phase I, dose-escalation, multicenter study of ACT-PFK-158, 2HCl in patients with advanced solid malignancies explores a first-in-human inhibitor of glycolysis.

  2015cited by this paper
• Pro-apoptotic effect of Persea americana var. Hass (avocado) on Jurkat lymphoblastic leukemia cells

  2014cited by this paper
• Structural basis of microtubule stabilization by laulimalide and peloruside A.

  2014cited by this paper
• Role of endoplasmic reticulum stress induction by the plant toxin, persin, in overcoming resistance to the apoptotic effects of tamoxifen in human breast cancer cells

  2013cited by this paper
• Oridonin ring A-based diverse constructions of enone functionality: identification of novel dienone analogues effective for highly aggressive breast cancer by inducing apoptosis.

  2013cited by this paper
• Methods for studying microtubule binding site interactions: zampanolide as a covalent binding agent.

  2013cited by this paper
• Molecular Mechanism of Action of Microtubule-Stabilizing Anticancer Agents

  2013cited by this paper
• Peloruside- and Laulimalide-Resistant Human Ovarian Carcinoma Cells Have βI-Tubulin Mutations and Altered Expression of βII- and βIII-Tubulin Isotypes

  2011cited by this paper
• Synthesis and in vitro evaluation of analogues of avocado-produced toxin (+)-(R)-persin in human breast cancer cells.

  2011cited by this paper
• Synergistic interactions between peloruside A and other microtubule-stabilizing and destabilizing agents in cultured human ovarian carcinoma cells and murine T cells

  2011cited by this paper
• Avocado fruit (Persea americana Mill) exhibits chemo-protective potentiality against cyclophosphamide induced genotoxicity in human lymphocyte culture.

  2011influential reference
• Paclitaxel directly binds to Bcl-2 and functionally mimics activity of Nur77.

  2009cited by this paper
• Microtubule-stabilizing activity of zampanolide, a potent macrolide isolated from the Tongan marine sponge Cacospongia mycofijiensis.

  2009cited by this paper
• Selective Induction of Apoptosis of Human Oral Cancer Cell Lines by Avocado Extracts Via a ROS-Mediated Mechanism

  2009cited by this paper
• Chemopreventive characteristics of avocado fruit.

  2007cited by this paper
• Peloruside A synergizes with other microtubule stabilizing agents in cultured cancer cell lines.

  2007cited by this paper
• Synergistic cytotoxicity between tamoxifen and the plant toxin persin in human breast cancer cells is dependent on Bim expression and mediated by modulation of ceramide metabolism

  2007cited by this paper
• Inflammation, a Key Event in Cancer Development

  2006cited by this paper
• A novel plant toxin, persin, with in vivo activity in the mammary gland, induces Bim-dependent apoptosis in human breast cancer cells

  2006cited by this paper
• Synergistic Suppression of Microtubule Dynamics by Discodermolide and Paclitaxel in Non-Small Cell Lung Carcinoma Cells

  2004cited by this paper
• Novel Antifeedant and Insecticidal Compounds from Avocado Idioblast Cell Oil

  2004cited by this paper
• Microtubules as a target for anticancer drugs

  2004cited by this paper
• Peloruside A Does Not Bind to the Taxoid Site on β-Tubulin and Retains Its Activity in Multidrug-Resistant Cell Lines

  2004cited by this paper
• Advances in Brief Peloruside A Does Not Bind to the Taxoid Site on-Tubulin and Retains Its Activity in Multidrug-Resistant Cell Lines

  2004cited by this paper
• Bcl-2 down-regulation is a novel mechanism of paclitaxel resistance.

  2003cited by this paper
• Synergistic Interaction Between Vinorelbine and Gamma-Linolenic Acid in Breast Cancer Cells

  2002cited by this paper
• MUTATIONS IN BETATUBULIN MAP TO DOMAINS INVOLVED IN REGULATION OF MICROTUBULE STABILITY IN EPOTHILONE-RESISTANT CELL LINES

  2001cited by this paper
• Induction of apoptosis by the marine sponge (Mycale) metabolites, mycalamide A and pateamine

  2001cited by this paper
• Mutations in -Tubulin Map to Domains Involved in Regulation of Microtubule Stability in Epothilone- resistant Cell Lines

  2001cited by this paper
• Effects of gamma-linolenic acid and oleic acid on paclitaxel cytotoxicity in human breast cancer cells.

  2001cited by this paper
• Mutations in beta-tubulin map to domains involved in regulation of microtubule stability in epothilone-resistant cell lines.

  2001cited by this paper
• Acetyl-CoA Carboxylase Inhibitors from Avocado (Persea americana Mill) Fruits

  2001cited by this paper
• A common pharmacophore for epothilone and taxanes: molecular basis for drug resistance conferred by tubulin mutations in human cancer cells.

  2000cited by this paper
• Peloruside A: a potent cytotoxic macrolide isolated from the new zealand marine sponge Mycale sp.

  2000cited by this paper
• 2-Hydroxy-4-oxohenicosan-1-yl Acetate. Its Presence in Avocado and its Simple Chemistry

  2000cited by this paper
• Discodermolide: just another microtubule-stabilizing agent? No! A lesson in synergy.

  2000cited by this paper
• Taxol and discodermolide represent a synergistic drug combination in human carcinoma cell lines.

  2000cited by this paper
• The proapoptotic activity of the Bcl-2 family member Bim is regulated by interaction with the dynein motor complex.

  1999cited by this paper
• Isolation, identification, and biological activity of isopersin, a new compound from avocado idioblast oil cells

  1998cited by this paper
• Gamma linolenic acid with tamoxifen as primary therapy in breast cancer

  1998cited by this paper
• The microtubule-stabilizing agent discodermolide competitively inhibits the binding of paclitaxel (Taxol) to tubulin polymers, enhances tubulin nucleation reactions more potently than paclitaxel, and inhibits the growth of paclitaxel-resistant cells.

  1997cited by this paper
• Paclitaxel-resistant Human Ovarian Cancer Cells Have Mutant β-Tubulins That Exhibit Impaired Paclitaxel-driven Polymerization*

  1997cited by this paper
• Taxol induces bcl-2 phosphorylation and death of prostate cancer cells.

  1996cited by this paper
• Induction of the

  1996cited by this paper
• Isolation and identification of a compound from avocado (Persea americana) leaves which causes necrosis of the acinar epithelium of the lactating mammary gland and the myocardium.

  1995cited by this paper
• A SHORT ENANTIOSELECTIVE SYNTHESIS OF A BIOLOGICALLY ACTIVE COMPOUND FROM PERSEA AMERICANA

  1995cited by this paper
• A reversible arrest point in the late G1 phase of the mammalian cell cycle.

  1990cited by this paper
• Possible involvement of an antifungal diene in the latency of Colletotricum gloeosporioides on unripe avocado fruits.

  1982cited by this paper
• Isolation and Structure Elucidation of Growth Inhibitors for Silkworm Larvae from Avocado Leaves

  1975cited by this paper
• Poisonous plants of the United States and Canada

  1964cited by this paper

• Alterations in fatty acid metabolism in patients with schizophrenia in a multi-omics perspective.

  2025cites this paper
• Beyond the Paclitaxel and Vinca Alkaloids: Next Generation of Plant-Derived Microtubule-Targeting Agents with Potential Anticancer Activity

  2020influential citation
• Palta: compuestos bioactivos y sus potenciales beneficios en salud

  2019cites this paper
• Targeting and extending the eukaryotic druggable genome with natural products: cytoskeletal targets of natural products.

  2019cites this paper
• Peloruside E (22-Norpeloruside A), a Pelorusane Macrolide from the New Zealand Marine Sponge Mycale hentscheli, Retains Microtubule-Stabilizing Properties.

  2018cites this paper
• Zampanolides B-E from the Marine Sponge Cacospongia mycofijiensis: Potent Cytotoxic Macrolides with Microtubule-Stabilizing Activity.

  2018cites this paper