Hypocretin1/OrexinA‐containing axons innervate locus coeruleus neurons that project to the Rat medial prefrontal cortex. Implication in the sleep‐wakefulness cycle and cortical activation

No abstract is available for this paper.

• Publication year

  2011

• Venue

  Synapse

• Publication date

  2011-03-10

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1002/syn.20912PMID 21308795
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Medial prefrontal cortex receives input from dorsal raphe nucleus neurons targeted by hypocretin1/orexinA-containing axons.

  2011cited by this paper
• Understanding wiring and volume transmission.

  2010cited by this paper
• Σ * Fine Structure

  2010cited by this paper
• Sleep Homeostasis Modulates Hypocretin-Mediated Sleep-to-Wake Transitions

  2009cited by this paper
• Orexin/Hypocretin and Histamine: Distinct Roles in the Control of Wakefulness Demonstrated Using Knock-Out Mouse Models

  2009cited by this paper
• Role of orexin input in the diurnal rhythm of locus coeruleus impulse activity.

  2008cited by this paper
• Sleep‐wakefulness effects after microinjections of hypocretin 1 (orexin A) in cholinoceptive areas of the cat oral pontine tegmentum

  2008cited by this paper
• [Modulation by the hypocretinergic/orexinergic neurotransmission system in sleep-wakefulness cycle states].

  2007cited by this paper
• Neural substrates of awakening probed with optogenetic control of hypocretin neurons

  2007cited by this paper
• Cellular and subcellular distributions of delta opioid receptor activation sites in the ventral oral pontine tegmentum of the cat.

  2006cited by this paper
• Relationship between the perifornical hypothalamic area and oral pontine reticular nucleus in the rat. Possible implication of the hypocretinergic projection in the control of rapid eye movement sleep

  2006cited by this paper
• Characterization of orexin A immunoreactivity in the rat area postrema.

  2005cited by this paper
• Orexin 1 Receptor Activation Attenuates Neurogenic Dural Vasodilation in an Animal Model of Trigeminovascular Nociception

  2005cited by this paper
• Orexins cause depolarization via nonselective cationic and K+ channels in isolated locus coeruleus neurons.

  2005cited by this paper
• Discharge of Identified Orexin/Hypocretin Neurons across the Sleep-Waking Cycle

  2005influential reference
• The orexinergic synaptic innervation of serotonin- and orexin 1-receptor-containing neurons in the dorsal raphe nucleus.

  2005cited by this paper
• Behavioral correlates of activity in identified hypocretin/orexin neurons.

  2005cited by this paper
• Ultrastructural localization of Leu5‐enkephalin immunoreactivity in mesocortical neurons and their input terminals in rat ventral tegmental area

  2004cited by this paper
• The locus coeruleus-noradrenergic system: modulation of behavioral state and state-dependent cognitive processes.

  2003cited by this paper
• The Nature of the Arrestin·Receptor Complex Determines the Ultimate Fate of the Internalized Receptor*

  2003cited by this paper
• Electron microscopic examination of the orexin immunoreactivity in the dorsal raphe nucleus.

  2003cited by this paper
• Colocalization of orexin a and glutamate immunoreactivity in axon terminals in the tuberomammillary nucleus in rats.

  2003influential reference
• Electron microscopic immunolabeling of transporters and receptors identifies transmitter-specific functional sites envisioned in Cajal's neuron.

  2002cited by this paper
• Low cerebrospinal fluid hypocretin (orexin) and altered energy homeostasis in human narcolepsy

  2001cited by this paper
• Hypocretin receptor protein and mRNA expression in the dorsolateral pons of rats.

  2001cited by this paper
• Low cerebrospinal fluid hypocretin (orexin) and altered energy homeostasis in human narcolepsy

  2001cited by this paper
• Differential expression of orexin receptors 1 and 2 in the rat brain

  2001cited by this paper
• The posterior hypothalamic area: chemoarchitecture and afferent connections.

  2001cited by this paper
• Hypocretin-1 Modulates Rapid Eye Movement Sleep through Activation of Locus Coeruleus Neurons

  2000influential reference
• A mutation in a case of early onset narcolepsy and a generalized absence of hypocretin peptides in human narcoleptic brains

  2000cited by this paper
• Reduced Number of Hypocretin Clinical Study Neurons in Human Narcolepsy

  2000cited by this paper
• Hypocretin (orexin) deficiency in human narcolepsy.

  2000cited by this paper
• Orexins, orexigenic hypothalamic peptides, interact with autonomic, neuroendocrine and neuroregulatory systems.

  1999cited by this paper
• The sleep disorder canine narcolepsy is caused by a mutation in the hypocretin (orexin) receptor 2 gene.

  1999cited by this paper
• Synaptic Interaction between Hypocretin (Orexin) and Neuropeptide Y Cells in the Rodent and Primate Hypothalamus: A Novel Circuit Implicated in Metabolic and Endocrine Regulations

  1999cited by this paper
• Locus coeruleus neurons: cessation of activity during cataplexy.

  1999cited by this paper
• Orexin A activates locus coeruleus cell firing and increases arousal in the rat.

  1999cited by this paper
• Hypocretin (orexin) activation and synaptic innervation of the locus coeruleus noradrenergic system

  1999cited by this paper
• Narcolepsy in orexin knockout mice: molecular genetics of sleep regulation.

  1999cited by this paper
• Distribution of orexin receptor mRNA in the rat brain

  1998cited by this paper
• Orexins and orexin receptors: a family of hypothalamic neuropeptides and G protein-coupled receptors that regulate feeding behavior.

  1998influential reference
• Hypocretin/Orexin‐ and melanin‐concentrating hormone‐expressing cells form distinct populations in the rodent lateral hypothalamus: Relationship to the neuropeptide Y and agouti gene‐related protein systems

  1998cited by this paper
• The hypocretins: hypothalamus-specific peptides with neuroexcitatory activity.

  1998influential reference
• Neurons Containing Hypocretin (Orexin) Project to Multiple Neuronal Systems

  1998influential reference
• Orexins and orexin receptors: a family of hypothalamic neuropeptides and G protein-coupled receptors that regulate feeding behavior.

  1998cited by this paper
• Associations between neuropeptide Y nerve terminals and intraparenchymal microvessels in rat and human cerebral cortex

  1997cited by this paper
• Enkephalin terminals form inhibitory-type synapses on neurons in the rat nucleus locus coeruleus that project to the medial prefrontal cortex.

  1996cited by this paper
• Ultrastructural analysis of tryptophan hydroxylase immunoreactive nerve terminals in the rat cerebral cortex and hippocampus: their associations with local blood vessels.

  1995cited by this paper
• Anatomical evidence for the presence of glutamate or enkephalin in noradrenergic projection neurons of the locus coeruleus

  1994cited by this paper
• Effects of locus coeruleus inactivation on electroencephalographic activity in neocortex and hippocampus.

  1993cited by this paper
• Brain Maps: Structure of the Rat Brain

  1992cited by this paper
• Effects of locus coeruleus activation on electroencephalographic activity in neocortex and hippocampus

  1991cited by this paper
• Exocytosis from neuronal large dense-cored vesicles.

  1990cited by this paper
• The glucose oxidase-DAB-nickel method in peroxidase histochemistry of the nervous system.

  1988cited by this paper
• Exocytosis from large dense cored vesicles outside the active synaptic zones of terminals within the trigeminal subnucleus caudalis: a possible mechanism for neuropeptide release.

  1986cited by this paper
• A comparative study of the behavioral effects of the locus coeruleus and the dorsal noradrenergic bundle lesions in the rat.

  1984cited by this paper
• The distribution of neocortical projection neurons in the locus coeruleus

  1983influential reference
• The rat brain in stereotaxic coordinates: Authors: George Paxinos & Charles Watson Academic Press Australia, 1982 Softback, 154 pages (including 71 plates), 35.00 Aust $

  1983influential reference
• Locus coeruleus projections to cortex: topography, morphology and collateralization.

  1982cited by this paper
• Use of avidin-biotin-peroxidase complex (ABC) in immunoperoxidase techniques: a comparison between ABC and unlabeled antibody (PAP) procedures.

  1981influential reference
• Sleep cycle oscillation: reciprocal discharge by two brainstem neuronal groups.

  1975cited by this paper
• THE USE OF LEAD CITRATE AT HIGH pH AS AN ELECTRON-OPAQUE STAIN IN ELECTRON MICROSCOPY

  1963influential reference
• Axo-somatic and axo-dendritic synapses of the cerebral cortex: an electron microscope study.

  1959cited by this paper
• NEUROPHYSIOLOGY: Hypocretin/orexin depolarizes and decreases potassium conductance in locus coeruleus neurons

  year unknowncited by this paper

• Hypocretin/orexin peptide release occurs mostly extrasynaptically, is self-controlled, and specifically enhanced in female rats.

  2025cites this paper
• Discovery of natural orexin 2 receptor antagonists from Valeriana species: A potential approach for insomnia treatment

  2025cites this paper
• Anatomy of the Locus Coeruleus Defined by a Multimodal Approach.

  2025cites this paper
• The Impact of Vestibular Stimulation on Sleep and Respiration in Humans

  2024cites this paper
• Hypocretin/orexin neurons encode social discrimination and exhibit a sex-dependent necessity for social interaction

  2023influential citation
• Hypothalamic orexinergic neuron changes during the hibernation of the Syrian hamster

  2022cites this paper
• Extracellular Calcium Contributes to Orexin-Induced Postsynaptic Excitation of the Rat Locus Coeruleus Neurons

  2022cites this paper
• Sex-dependent role of hypocretin/orexin neurons in social behavior

  2022influential citation
• Physiological Role of Orexinergic System for Health

  2022cites this paper
• The Role of Orexin in Alzheimer Disease: From Sleep-wake Disturbance to Therapeutic Target.

  2021cites this paper
• The hypocretin (orexin) system: from a neural circuitry perspective.

  2020cites this paper
• Neuroimaging correlates of narcolepsy with cataplexy: A systematic review.

  2019cites this paper
• Sleep, Stress, and Traumatic Memory

  2019cites this paper
• Sympathetic nerve activity and neuro‐inflammation: Who is in the driver's seat?

  2018cites this paper
• Intermittent Short Sleep May Contribute to Orexinergic Signaling Dysregulation in Alzheimer's Disease.

  2017cites this paper
• Role of the Orexin System on the Hypothalamus-Pituitary-Thyroid Axis

  2016cites this paper
• Orexinergic system in the locus coeruleus modulates the CO2 ventilatory response

  2016cites this paper
• Effect of Heweianshen Decoction on Orexin-A and Cholecystokinin-8 Expression in Rat Models of Insomnia

  2016cites this paper
• Control of arousal through neuropeptide afferents of the locus coeruleus.

  2016cites this paper
• Region-Specific Dissociation between Cortical Noradrenaline Levels and the Sleep/Wake Cycle.

  2016cites this paper
• Modulation of Thalamocortical Pathways by Orexins

  2015cites this paper
• Molecular influences on working memory circuits in dorsolateral prefrontal cortex.

  2014cites this paper
• Organization of the orexin/hypocretin system in the brain of two basal actinopterygian fishes, the cladistians Polypterus senegalus and Erpetoichthys calabaricus.

  2014cites this paper
• LSN2424100: a novel, potent orexin-2 receptor antagonist with selectivity over orexin-1 receptors and activity in an animal model predictive of antidepressant-like efficacy

  2014influential citation
• Hypocretin1/orexinA-immunoreactive axons form few synaptic contacts on rat ventral tegmental area neurons that project to the medial prefrontal cortex

  2014cites this paper
• Forebrain GABAergic projections to locus coeruleus in mouse

  2013cites this paper
• Orexin receptor antagonists as therapeutic agents for insomnia

  2013cites this paper
• Memory processing: the critical role of neuronal replay during sleep.

  2013cites this paper
• Sleep physiology: setting the right tone.

  2013cites this paper
• Synaptic interactions between perifornical lateral hypothalamic area, locus coeruleus nucleus and the oral pontine reticular nucleus are implicated in the stage succession during sleep-wakefulness cycle

  2013cites this paper
• Toward an Understanding of Agonist Binding to Human Orexin-1 and Orexin-2 Receptors with G-Protein-Coupled Receptor Modeling and Site-Directed Mutagenesis

  2013cites this paper
• Functional neuroanatomy of the central noradrenergic system

  2013cites this paper
• Pathophysiology of Acute Coma and Disorders of Consciousness: Considerations for Diagnosis and Management

  2013cites this paper
• Treatment of cataplexy

  2013cites this paper
• Efectos en el ciclo vigilia-sueño producidos por administración de histamina en regiones colinoceptivas del tegmento pontino: estudio experimental en el gato de laboratorio

  2013cites this paper
• Electroacupuncture Enhances Motor Recovery Performance with Brain-Derived Neurotrophic Factor Expression in Rats with Cerebral Infarction

  2012cites this paper
• Adenosina y control homeostático del sueño: Acciones en estructuras diana de los circuitos de vigilia y sueño

  2012cites this paper
• Study of human Orexin-1 and -2 G-protein-coupled receptors with novel and published antagonists by modeling, molecular dynamics simulations, and site-directed mutagenesis.

  2012cites this paper
• Immunohistochemical evidence for synaptic release of GABA from melanin-concentrating hormone containing varicosities in the locus coeruleus.

  2012cites this paper
• Modulation of neurotransmitter release in orexin/hypocretin‐2 receptor knockout mice: A microdialysis study

  2012cites this paper
• [Adenosine and homeostatic control of sleep. Actions in target structures of the sleep-wake circuits].

  2012cites this paper
• Orexin-A excites pyramidal neurons in layer 2/3 of the rat prefrontal cortex.

  2012cites this paper
• EEG effect of orexin A in freely moving rats.

  2012cites this paper
• The gray area between synapse structure and function—Gray's synapse types I and II revisited

  2011cites this paper