The membrane bile acid receptor TGR5 drives cell growth and migration via activation of the JAK2/STAT3 signaling pathway in non-small cell lung cancer.

No abstract is available for this paper.

• Publication year

  2018

• Venue

  Cancer Letters

• Publication date

  Unknown publication date

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1016/j.canlet.2017.10.017PMID 29074425
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• MicroRNA-148a suppresses proliferation and invasion potential of non-small cell lung carcinomas via regulation of STAT3

  2017cited by this paper
• Farnesoid X receptor, a novel proto-oncogene in non-small cell lung cancer, promotes tumor growth via directly transactivating CCND1

  2017cited by this paper
• Role of STAT3 in Genesis and Progression of Human Malignant Gliomas

  2017cited by this paper
• Ruxolitinib for symptom control in patients with Chronic Lymphocytic leukemia: A Phase II Trial

  2017cited by this paper
• Combination Therapy Targeting BCL6 and Phospho-STAT3 Defeats Intratumor Heterogeneity in a Subset of Non-Small Cell Lung Cancers.

  2017cited by this paper
• Ginsenoside 20(S)-Rh2 exerts anti-cancer activity through targeting IL-6-induced JAK2/STAT3 pathway in human colorectal cancer cells.

  2016cited by this paper
• Liquid Biopsy in Lung Cancer: A Perspective From Members of the Pulmonary Pathology Society.

  2016cited by this paper
• Membrane bile acid receptor TGR5 predicts good prognosis in ampullary adenocarcinoma patients with hyperbilirubinemia

  2016cited by this paper
• Bile acids induce activation of alveolar epithelial cells and lung fibroblasts through farnesoid X receptor‐dependent and independent pathways

  2016cited by this paper
• Place du ruxolitinib dans la stratégie thérapeutique des syndromes myéloprolifératifs

  2016cited by this paper
• miRNA-133b and miRNA-135a induce apoptosis via the JAK2/STAT3 signaling pathway in human renal carcinoma cells.

  2016cited by this paper
• [Not Available].

  2016cited by this paper
• TGR5 is essential for bile acid-dependent cholangiocyte proliferation in vivo and in vitro

  2015cited by this paper
• The G-protein-coupled bile acid receptor Gpbar1 (TGR5) suppresses gastric cancer cell proliferation and migration through antagonizing STAT3 signaling pathway

  2015cited by this paper
• Global cancer statistics, 2012

  2015cited by this paper
• The bile acid TGR5 membrane receptor: from basic research to clinical application.

  2014cited by this paper
• Revisiting STAT3 signalling in cancer: new and unexpected biological functions

  2014cited by this paper
• Aberrant DNA Methylation of G-protein-coupled Bile Acid Receptor Gpbar1 (TGR5) is a Potential Biomarker for Hepatitis B Virus Associated Hepatocellular Carcinoma

  2014cited by this paper
• Deficiency of G‐protein‐coupled bile acid receptor Gpbar1 (TGR5) enhances chemically induced liver carcinogenesis

  2013cited by this paper
• Bile acids: from digestion to cancers.

  2013cited by this paper
• Expression of bile acid receptor TGR5 in gastric adenocarcinoma.

  2013cited by this paper
• Chenodeoxycholic acid through a TGR5-dependent CREB signaling activation enhances Cyclin D1 expression and promotes human endometrial cancer cell proliferation

  2012cited by this paper
• The bile acid membrane receptor TGR5 as an emerging target in metabolism and inflammation.

  2011cited by this paper
• The JAK2/STAT3 signaling pathway is required for growth of CD44⁺CD24⁻ stem cell-like breast cancer cells in human tumors.

  2011cited by this paper
• Bile alcohols function as the ligands of membrane-type bile acid-activated G protein-coupled receptor

  2010cited by this paper
• Role of a novel bile acid receptor TGR5 in the development of oesophageal adenocarcinoma

  2009cited by this paper
• Plumbagin inhibits invasion and migration of liver cancer HepG2 cells by decreasing productions of matrix metalloproteinase‐2 and urokinase‐ plasminogen activator

  2009cited by this paper
• Involvement of membrane-type bile acid receptor M-BAR/TGR5 in bile acid-induced activation of epidermal growth factor receptor and mitogen-activated protein kinases in gastric carcinoma cells.

  2007cited by this paper
• The sulphorhodamine (SRB) assay and other approaches to testing plant extracts and derived compounds for activities related to reputed anticancer activity.

  2007cited by this paper
• Activation of Stat3 in Primary Tumors from High-Risk Breast Cancer Patients Is Associated with Elevated Levels of Activated Src and Survivin Expression

  2006cited by this paper
• Hepatocellular carcinoma in ten children under five years of age with bile salt export pump deficiency

  2006cited by this paper
• The Effect of Reflux and Bile Acid Aspiration on the Lung Allograft and Its Surfactant and Innate Immunity Molecules SP‐A and SP‐D

  2006cited by this paper
• Bile acid aspiration and the development of bronchiolitis obliterans after lung transplantation.

  2005cited by this paper
• Deoxycholic acid activates beta-catenin signaling pathway and increases colon cell cancer growth and invasiveness.

  2004cited by this paper
• Bile acid pneumonia: a "new" form of neonatal respiratory distress syndrome?

  2004cited by this paper
• The enzymes, regulation, and genetics of bile acid synthesis.

  2003cited by this paper
• A G Protein-coupled Receptor Responsive to Bile Acids*

  2003cited by this paper
• Three hypotheses linking bile to carcinogenesis in the gastrointestinal tract: certain bile salts have properties that may be used to complement chemotherapy.

  2002cited by this paper
• Identification of membrane-type receptor for bile acids (M-BAR).

  2002cited by this paper
• STAT3 activation abrogates growth factor dependence and contributes to head and neck squamous cell carcinoma tumor growth in vivo.

  2002cited by this paper
• The Jak-STAT pathway.

  2000cited by this paper

• Thermogenesis in Adipose Tissue: Adrenergic and Non-Adrenergic Pathways

  2026influential citation
• The Dynamic Gut Microbiota: Monitoring Alterations During Lung Cancer Progression for Diagnosis and Precision Medicine.

  2026cites this paper
• Bile acid metabolism and invasion-related genes as therapeutic monitoring biomarkers in non-small cell lung cancer

  2025cites this paper
• Immune-oncology-microbiome axis in lung cancer: from carcinogenesis to therapy—a narrative review

  2025cites this paper
• Causality of genetically determined gut microbiota on lung cancer: a Mendelian randomization study

  2025cites this paper
• G protein-coupled receptors as novel therapeutic targets in non-small-cell lung cancer

  2025cites this paper
• Deoxycholic Acid Drives ATP4A-Dependent Growth and Migration of Vocal Fold Leukoplakia Epithelial Cells via TGR5/JAK2/STAT3 Signaling.

  2025cites this paper
• Ursodeoxycholic Acid Platinum(IV) Conjugates as Antiproliferative and Antimetastatic Agents: Remodel the Tumor Microenvironment through Suppressing JAK2/STAT3 Signaling.

  2024cites this paper
• Organic anion transporters in remote sensing and organ crosstalk.

  2024cites this paper
• Activation of the G Protein-Coupled Bile Acid Receptor TGR5 Modulates the HCP5/miR-139-5p/DDIT4 Axis to Antagonize Cervical Cancer Progression

  2024cites this paper
• Gut microbial metabolites in lung cancer development and immunotherapy: Novel insights into gut-lung axis.

  2024cites this paper
• Conjugated bile acids alleviate acute pancreatitis through inhibition of TGR5 and NLRP3 mediated inflammation

  2024cites this paper
• Study on the inhibition of non-small cell lung cancer mediated by chitosan-based gene carrier delivering STAT3-shRNA.

  2024cites this paper
• Predictive value of direct bilirubin and total bile acid in lung adenocarcinoma patients treated with EGFR-TKIs

  2024cites this paper
• Yi-Fei-San-Jie Chinese medicine formula reverses immune escape by regulating deoxycholic acid metabolism to inhibit TGR5/STAT3/PD-L1 axis in lung cancer

  2024cites this paper
• TGR5 deficiency in excitatory neurons ameliorates Alzheimer’s pathology by regulating APP processing

  2024cites this paper
• Lung cancer metabolomics: a pooled analysis in the Cancer Prevention Studies

  2024cites this paper
• Update on the development of TGR5 agonists for human diseases.

  2024cites this paper
• Bile acid metabolism and signaling in health and disease: molecular mechanisms and therapeutic targets

  2024cites this paper
• Farnesoid X receptor promotes non-small cell lung cancer metastasis by activating Jak2/STAT3 signaling via transactivation of IL-6ST and IL-6 genes

  2024cites this paper
• Application of a nomogram from coagulation-related biomarkers and C1q and total bile acids in distinguishing advanced and early-stage lung cancer

  2024cites this paper
• Inulin enhanced rifaximin-inhibited colon cancer pulmonary metastasis by flora-regulated bile acid pathway.

  2024cites this paper
• GPBAR1 is associated with asynchronous bone metastasis and poor prognosis of hepatocellular carcinoma

  2023cites this paper
• Molecular orchestra of microbiotic metabolites in the scenario of carcinogenesis

  2023cites this paper
• β−Arrestins: Structure, Function, Physiology, and Pharmacological Perspectives

  2023cites this paper
• The kidney drug transporter OAT1 regulates gut microbiome–dependent host metabolism

  2023cites this paper
• Alteration of serum bile acids in non-small cell lung cancer identified by a validated LC–MS/MS method

  2023influential citation
• Molecular Ensembles of Microbiotic Metabolites in Carcinogenesis

  2023cites this paper
• Research on Gut Microbiota-Derived Secondary Bile Acids in Cancer Progression

  2022cites this paper
• Role of JAK2/STAT3 Signaling Pathway in the Tumorigenesis, Chemotherapy Resistance, and Treatment of Solid Tumors: A Systemic Review

  2022cites this paper
• The role of bile acids in carcinogenesis

  2022cites this paper
• Structural basis and molecular mechanism of biased GPBAR signaling in regulating NSCLC cell growth via YAP activity

  2022cites this paper
• The Bile Acid Membrane Receptor TGR5 in Cancer: Friend or Foe?

  2022cites this paper
• The role of TGR5 as an onco-immunological biomarker in tumor staging and prognosis by encompassing the tumor microenvironment

  2022cites this paper
• Analysis of the HNF4A isoform-regulated transcriptome identifies CCL15 as a downstream target in gastric carcinogenesis

  2021cites this paper
• GPBAR1 Promotes Proliferation of Serous Ovarian Cancer by Inducing Smad4 Ubiquitination

  2021cites this paper
• Mulberrofuran G inhibits proliferation and migration by inactivating JAK2/STAT3 signaling in lung cancer

  2021cites this paper
• TGR5 deficiency activates antitumor immunity in non-small cell lung cancer via restraining M2 macrophage polarization

  2021cites this paper
• The gut microbiome-bile acid axis in hepatocarcinogenesis.

  2021cites this paper
• The Ability of Metabolomics to Discriminate Non-Small-Cell Lung Cancer Subtypes Depends on the Stage of the Disease and the Type of Material Studied

  2021cites this paper
• Discovery of chemerin as the new chemoattractant of human mesenchymal stem cells

  2021cites this paper
• Gut Microbiota and Gynecological Cancers: A Summary of Pathogenetic Mechanisms and Future Directions.

  2021cites this paper
• Effects of Bushen Jiedu Sanjie Recipe on deoxycholic acid⁃induced TGR5 activity and invasion and metastasis of human colon cancer cells

  2020cites this paper
• TGR5-HNF4α axis contributes to bile acid-induced gastric intestinal metaplasia markers expression

  2020cites this paper
• Microbiome, bile acids, and obesity: How microbially modified metabolites shape anti‐tumor immunity

  2020cites this paper
• Specific gut microbiome signature predicts the early-stage lung cancer

  2020cites this paper
• LncRNA DLEU2 promotes tumour growth by sponging miR‐337‐3p in human osteosarcoma

  2020cites this paper
• Prognostic significance of artemin in gastric cancer and its role in tumorigenesis

  2020influential citation
• Metabolomic profiling of dried blood spots reveals gender-specific discriminant models for the diagnosis of small cell lung cancer

  2020cites this paper
• TGR5-HNF4α axis contributes to bile acid-induced gastric intestinal metaplasia markers expression

  2020cites this paper
• Taurochenodeoxycholic acid mediates cAMP-PKA-CREB signaling pathway.

  2020cites this paper
• The cardiovascular protective effect and mechanism of calycosin and its derivatives.

  2020cites this paper
• The Anticancer Mechanism of Bile Acid Receptor TGR5 in Mouse Models of Lung Cancer

  2020cites this paper
• Metabolite Sensing GPCRs: Promising Therapeutic Targets for Cancer Treatment?

  2020cites this paper
• TGR5/Cathepsin E signaling regulates macrophage innate immune activation in liver ischemia and reperfusion injury

  2020cites this paper
• MALT1 Inhibition as a Therapeutic Strategy in T-Cell Acute Lymphoblastic Leukemia by Blocking Notch1-Induced NF-κB Activation

  2020cites this paper
• Intestinales Mikrobiom und humanes Metabolom

  2019cites this paper
• Ursodeoxycholic acid and cancer: From chemoprevention to chemotherapy.

  2019cites this paper
• Smoking as an Independent Risk Factor for Hepatocellular Carcinoma Due to the α7-Nachr Modulating the JAK2/STAT3 Signaling Axis

  2019cites this paper
• 15-Lipoxygenase-2/15(S)-hydroxyeicosatetraenoic acid regulates cell proliferation and metastasis via the STAT3 pathway in lung adenocarcinoma.

  2018cites this paper
• High expression of TGR5 predicts a poor prognosis in patients with pancreatic cancer.

  2018cites this paper
• mRNA chip‐based analysis on transcription factor regulatory network central nodes of protection targets of Deproteinized Extract of Calf Blood on acute liver injury in mice

  2018cites this paper