Use of neuromelanin-sensitive MRI to distinguish schizophrenic and depressive patients and healthy individuals based on signal alterations in the substantia nigra and locus ceruleus.

No abstract is available for this paper.

• Publication year

  2008

• Venue

  Biological Psychiatry

• Publication date

  2008-09-01

• Fields of study

  Medicine, Psychology

• Identifiers
  DOI 10.1016/j.biopsych.2008.03.021PMID 18452894
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Reduced signal of locus ceruleus in depression in quantitative neuromelanin magnetic resonance imaging

  2007cited by this paper
• Neuromelanin magnetic resonance imaging of locus ceruleus and substantia nigra in Parkinson's disease

  2006cited by this paper
• Age-related changes in locus ceruleus on neuromelanin magnetic resonance imaging at 3 Tesla.

  2006cited by this paper
• The locus coeruleus in schizophrenia: a postmortem study of noradrenergic neurones

  2005cited by this paper
• Variability of the mesolimbic neuronal activity in a rat model of depression

  2005cited by this paper
• Structural and functional models of depression: from sub‐types to substrates

  2005cited by this paper
• Unipolar-bipolar dichotomy of mood disorders is supported by noradrenergic brainstem system morphology.

  1999cited by this paper
• NMR relaxation times in the human brain at 3.0 tesla

  1999cited by this paper
• The regulation of forebrain dopamine transmission: relevance to the pathophysiology and psychopathology of schizophrenia.

  1999cited by this paper
• Paramagnetic metal scavenging by melanin: MR imaging.

  1997cited by this paper
• Decreased prefrontal dopamine D1 receptors in schizophrenia revealed by PET

  1997cited by this paper
• Striatal D2 dopamine receptor characteristics in neuroleptic-naive schizophrenic patients studied with positron emission tomography.

  1994cited by this paper
• J Neuropsychiatry Clin Neurosci

  1992cited by this paper
• Magnetization transfer effects in multislice RARE sequences

  1992cited by this paper
• Staining intensity of brain iron in patients with schizophrenia: a postmortem study.

  1992cited by this paper
• Effects of the interaction between ferric iron and L‐dopa melanin on T1 and T2 relaxation times determined by magnetic resonance imaging

  1992cited by this paper
• D2 dopamine receptors in neuroleptic-naive schizophrenic patients. A positron emission tomography study with [11C]raclopride.

  1990cited by this paper
• Striatal D2 dopaminergic receptors assessed with positron emission tomography and [76Br]bromospiperone in untreated schizophrenic patients.

  1990cited by this paper
• Peripheral induction of burst firing in locus coeruleus neurons by nicotine mediated via excitatory amino acids

  1989cited by this paper
• The human locus coeruleus: computer reconstruction of cellular distribution

  1988cited by this paper
• Locus ceruleus morphometry in aging and schizophrenia

  1988cited by this paper
• Implications of normal brain development for the pathogenesis of schizophrenia.

  1987cited by this paper
• Overview: toward a dysregulation hypothesis of depression.

  1985cited by this paper
• Increased brain dopamine and dopamine receptors in schizophrenia.

  1982cited by this paper
• Neuromelanin, neuroleptics and schizophrenia: hypothesis of an interaction between noradrenergic and dopaminergic system.

  1980cited by this paper
• Neuromelanin, Neuroleptics and Schizophrenia

  1980cited by this paper
• On the origin and significance of neuromelanin.

  1979cited by this paper
• Biochemistry of neuromelanin.

  1974cited by this paper
• Biochemistry of neuromelanin.

  1974cited by this paper

• The potential of neuromelanin-sensitive MRI in psychiatric disorders

  2026cites this paper
• Neuromelanin Contrast Optimization and Improved Visualization of the Substantia Nigra in a 3D Gradient‐Echo Sequence With Magnetization Transfer

  2025cites this paper
• Norepinephrine system dysconnectivity in major depressive disorder: the effect of short term SSRI treatment.

  2025cites this paper
• Inverse Association of Locus Coeruleus MRI Integrity With Structural Volume and Its Impact on Individual's Inattentiveness

  2025cites this paper
• Locus Coeruleus Microstructure and Connectivity as Novel Markers of Depression and Cognitive Dysfunction in Older Adults.

  2025cites this paper
• Human Brain Magnetic Resonance Imaging Studies for Psychiatric Disorders: The Current Progress and Future Directions

  2024cites this paper
• Neuromelanin-Sensitive MRI as Candidate Marker for Treatment Resistance in First-Episode Schizophrenia.

  2024cites this paper
• Neuromelanin-sensitive magnetic resonance imaging in the study of mental disorder: A systematic review.

  2024cites this paper
• Evidence for locus coeruleus-norepinephrine system abnormality in military PTSD revealed by neuromelanin-sensitive MRI.

  2024cites this paper
• Neuromelanin-MRI identifies locus coeruleus and substantia nigra degeneration as key differentiators in isolated rapid eye movement sleep behavior disorder

  2024cites this paper
• Role of the locus coeruleus-noradrenergic system in stress-related psychopathology and resilience: clinical and pre-clinical evidences.

  2024cites this paper
• Neuromelanin-sensitive MRI for mechanistic research and biomarker development in psychiatry

  2024cites this paper
• Mesostriatal Dopaminergic Circuit Dysfunction in Schizophrenia: A Multimodal Neuromelanin-sensitive MRI and [18F]-DOPA PET Study.

  2024cites this paper
• Schizophrenia Animal Modeling with Epidermal Growth Factor and Its Homologs: Their Connections to the Inflammatory Pathway and the Dopamine System

  2023cites this paper
• The substantia nigra in the pathology of schizophrenia: A review on post-mortem and molecular imaging findings.

  2023cites this paper
• Neuromelanin-sensitive MRI of the substantia nigra distinguishes bipolar from unipolar depression.

  2023cites this paper
• Fronto-striato-thalamic circuit connectivity and neuromelanin in schizophrenia: an fMRI and neuromelanin-MRI study

  2023cites this paper
• Brain MRI Biomarkers in Isolated Rapid Eye Movement Sleep Behavior Disorder: Where Are We? A Systematic Review

  2023cites this paper
• Neuromelanin-sensitive MRI as a promising biomarker of catecholamine function.

  2023cites this paper
• A possible contribution of the locus coeruleus to arousal enhancement with mild exercise: evidence from pupillometry and neuromelanin imaging

  2023cites this paper
• Probing midbrain dopamine function in pediatric obsessive-compulsive disorder via neuromelanin-sensitive magnetic resonance imaging

  2023cites this paper
• Quantitative Susceptibility Mapping MRI in Deep-Brain Nuclei in First-Episode Psychosis.

  2023cites this paper
• Evidence for upregulation of excitatory synaptic transmission in the substantia nigra in Schizophrenia: a postmortem ultrastructural study

  2023cites this paper
• The Relationships Among Metal Homeostasis, Mitochondria, and Locus Coeruleus in Psychiatric and Neurodegenerative Disorders: Potential Pathogenetic Mechanism and Therapeutic Implications

  2022cites this paper
• neuromelanin-sensitive magnetic resonance imaging with semi-automated volume measurement of the for diagnosis Parkinson's disease

  2022cites this paper
• Sandwich spatial saturation for neuromelanin-sensitive MRI: Development and multi-center trial

  2022cites this paper
• Magnetic resonance imaging of the dopamine system in schizophrenia – A scoping review

  2022influential citation
• Associations between locus coeruleus integrity and diagnosis, age, and cognitive performance in older adults with and without late-life depression: An exploratory study

  2022cites this paper
• Evidence for Dopamine Abnormalities Following Acute Methamphetamine Exposure Assessed by Neuromelanin-Sensitive Magnetic Resonance Imaging

  2022cites this paper
• Consequences of Hyperphosphorylated Tau in the Locus Coeruleus on Behavior and Cognition in a Rat Model of Alzheimer’s Disease

  2022cites this paper
• Imaging of the dopamine system with focus on pharmacological MRI and neuromelanin imaging.

  2021cites this paper
• Consequences of endogenous and virally-induced hyperphosphorylated tau on behavior and cognition in a rat model of Alzheimer’s disease

  2021cites this paper
• Neuromelanin-Sensitive Magnetic Resonance Imaging in Schizophrenia: A Meta-Analysis of Case-Control Studies

  2021cites this paper
• Neuromelanin Accumulation in patients with schizophrenia: A Systematic Review and Meta-Analysis.

  2021influential citation
• Standardized Data Acquisition for Neuromelanin-sensitive Magnetic Resonance Imaging of the Substantia Nigra.

  2021cites this paper
• The Locus Coeruleus in Aging and Alzheimer’s Disease: A Postmortem and Brain Imaging Review

  2021cites this paper
• Lower Locus Coeruleus MRI intensity in patients with late-life major depression

  2021cites this paper
• Neuromelanin changes in first episode psychosis with substance abuse.

  2020cites this paper
• Evidence for altered excitatory and inhibitory tone in the post-mortem substantia nigra in schizophrenia

  2020cites this paper
• Ultrastructural evidence for glutamatergic dysregulation in schizophrenia.

  2020cites this paper
• What’s That (Blue) Spot on my MRI? Multimodal Neuroimaging of the Locus Coeruleus in Neurodegenerative Disease

  2020cites this paper
• Reliability and Reproducibility of Neuromelanin‐Sensitive Imaging of the Substantia Nigra: A Comparison of Three Different Sequences

  2020cites this paper
• P.523 Neuromelanin MRI as biomarker for treatment resistance in first episode schizophrenia patients

  2020cites this paper
• Locus Coeruleus Magnetic Resonance Imaging in Neurological Diseases

  2020cites this paper
• Neuromelanin-sensitive MRI as a noninvasive proxy measure of dopamine function in the human brain

  2019cites this paper
• Reproducibility assessment of neuromelanin-sensitive magnetic resonance imaging protocols for region-of-interest and voxelwise analyses

  2019cites this paper
• The locus coeruleus: The central relay between neuronal network activation and sympathetic responses in cognitive control

  2019cites this paper
• 3D neuromelanin-sensitive magnetic resonance imaging with semi-automated volume measurement of the substantia nigra pars compacta for diagnosis of Parkinson's disease

  2018cites this paper
• 3D neuromelanin-sensitive magnetic resonance imaging with semi-automated volume measurement of the substantia nigra pars compacta for diagnosis of Parkinson's disease

  2018cites this paper
• 3D neuromelanin-sensitive magnetic resonance imaging with semi-automated volume measurement of the substantia nigra pars compacta for diagnosis of Parkinson's disease

  2018cites this paper
• Locus Coeruleus atrophy doesn’t relate to fatigue in Parkinson’s disease

  2018cites this paper
• Neuromelanin magnetic resonance imaging of the substantia nigra in first episode psychosis patients consumers of illicit substances.

  2018cites this paper
• Age-related variability in decision-making: Insights from neurochemistry

  2018cites this paper
• Activation of brainstem and midbrain nuclei during cognitive control in medicated patients with schizophrenia

  2018cites this paper
• Local Brain Activity Differences Between Herpes Zoster and Postherpetic Neuralgia Patients: A Resting-State Functional MRI Study.

  2017cites this paper
• Normative data of dopaminergic neurotransmission functions in substantia nigra measured with MRI and PET: Neuromelanin, dopamine synthesis, dopamine transporters, and dopamine D2 receptors

  2017cites this paper
• Magnetic resonance imaging of the human locus coeruleus: A systematic review

  2017influential citation
• Optimal Cut-Off Value for Locus Coeruleus-to-Pons Intensity Ratio as Clinical Biomarker for Alzheimer’s Disease: A Pilot Study

  2017cites this paper
• Abnormal Local Brain Activity Beyond the Pain Matrix in Postherpetic Neuralgia Patients: A Resting-State Functional MRI Study.

  2017cites this paper
• The Neuromelanin-related T2* Contrast in Postmortem Human Substantia Nigra with 7T MRI

  2016cites this paper
• Instructions for use Title 3 D neuromelanin-sensitive magnetic resonance imaging with semi-automated volume measurement of the substantia nigra pars compacta for diagnosis of Parkinson ' s disease

  2016cites this paper
• A longitudinal study of neuromelanin-sensitive magnetic resonance imaging in Parkinson's disease.

  2016cites this paper
• Detection of changes in the ventral tegmental area of patients with schizophrenia using neuromelanin-sensitive MRI

  2016cites this paper
• A Comparison of Substantia Nigra T1 Hyperintensity in Parkinson's Disease Dementia, Alzheimer's Disease and Age-Matched Controls: Volumetric Analysis of Neuromelanin Imaging

  2016cites this paper
• Neurological soft signs in recent-onset schizophrenia: Focus on the cerebellum.

  2015cites this paper
• Automated Neuromelanin Imaging as a Diagnostic Biomarker for Parkinson's Disease

  2015cites this paper
• Diminished serum repetin levels in patients with schizophrenia and bipolar disorder

  2015cites this paper
• The role of the locus coeruleus-noradrenaline system in temporal attention and uncertainty processing

  2015cites this paper
• Sustained NMDA receptor hypofunction induces compromised neural systems integration and schizophrenia-like alterations in functional brain networks.

  2014cites this paper
• Functional and Structural MRI in Alzheimer’s Disease: A Multimodal Approach

  2014cites this paper
• Detection of changes in the locus coeruleus in patients with mild cognitive impairment and Alzheimer's disease: High-resolution fast spin-echo T1-weighted imaging

  2014cites this paper
• Neuromelanin Magnetic Resonance Imaging Reveals Increased Dopaminergic Neuron Activity in the Substantia Nigra of Patients with Schizophrenia

  2014cites this paper
• Magnetic transfer contrast accurately localizes substantia nigra confirmed by histology.

  2013influential citation
• Changes in substantia nigra and locus coeruleus in patients with early-stage Parkinson's disease using neuromelanin-sensitive MR imaging.

  2013cites this paper
• Neurological Soft Signs and Brainstem Morphology in First-Episode Schizophrenia

  2013cites this paper
• Chronic pain leads to concomitant noradrenergic impairment and mood disorders.

  2013cites this paper
• Vestibular insights into cognition and psychiatry.

  2013cites this paper
• 3D neuromelanin-sensitive magnetic resonance imaging with semi-automated volume measurement of the substantia nigra pars compacta for diagnosis of Parkinson’s disease

  2013cites this paper
• Neuromelanin Imaging in Parkinson Disease

  2013cites this paper
• Seven‐tesla magnetic resonance images of the substantia nigra in Parkinson disease

  2012cites this paper
• Use of imaging multivariate analysis to improve biochemical and anatomical discrimination in desorption electrospray ionisation mass spectrometry imaging.

  2012cites this paper
• Using High-Resolution MR Imaging at 7T to Evaluate the Anatomy of the Midbrain Dopaminergic System

  2011cites this paper
• Response to Comment on “Modafinil Shifts Human Locus Coeruleus to Low-Tonic, High-Phasic Activity During Functional MRI”

  2010cites this paper
• Comment on “Modafinil Shifts Human Locus Coeruleus to Low-Tonic, High-Phasic Activity During Functional MRI” and “Homeostatic Sleep Pressure and Responses to Sustained Attention in the Suprachiasmatic Area”

  2010cites this paper
• Visual discrimination among patients with depression and schizophrenia and healthy individuals using semiquantitative color-coded fast spin-echo T1-weighted magnetic resonance imaging

  2010influential citation
• In vivo mapping of the human locus coeruleus

  2009cites this paper
• MRI of Brain Iron and Neurodegenerative Diseases: A Potential Biomarker

  2009cites this paper
• Current Awareness in NMR in Biomedicine

  2009cites this paper
• Magnetic resonance molecular imaging: applications to stroke management

  2008cites this paper
• Monoamine neurons in the human brain stem: anatomy, magnetic resonance imaging findings, and clinical implications

  2008cites this paper
• Neuromelanin-Sensitive MRI

  2008cites this paper
• Chapter One Introduction 1-1 Prelude :

  year unknowncites this paper
• Mesostriatal Dopaminergic Circuit Dysfunction in Schizophrenia: A Multimodal Neuromelanin-Sensitive Magnetic Resonance Imaging and [ 18 F]-DOPA Positron Emission Tomography Study

  year unknowncites this paper