Heat shock potentiates aminoglycosides against gram-negative bacteria by enhancing antibiotic uptake, protein aggregation, and ROS

Significance Bacterial antibiotic resistance has become a severe threat to human and animal health. Increasing the efficacy of existing antibiotics is a promising strategy against antibiotic resistance. Here, we report that thermal treatment dramatically enhances the efficacy of aminoglycoside antibiotics in killing various bacteria, including multidrug-resistant pathogens. Mechanistically, such potentiation effect of thermal treatment is achieved by promoting the bacterial uptake of and enhancing the downstream lethality of aminoglycosides. Our study demonstrates a high potential of thermal treatment in curing antibiotic-resistance–associated bacterial infections when combined with aminoglycosides, thus expanding on its current application in treating tumors.

• Publication year

  2023

• Venue

  Proceedings of the National Academy of Sciences of the United States of America

• Publication date

  2023-03-14

• Fields of study

  Medicine, Chemistry, Environmental Science

• Identifiers
  DOI 10.1073/pnas.2217254120PMID 36917671PMCID 10041086
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

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