Overexpression of Lmo2 initiates T-lymphoblastic leukemia via impaired thymocyte competition

Abdulla et al. show that the LMO2 transcription factor, a key driver of human T-lymphoblastic leukemia, inhibits thymocyte competition in a transgenic mouse model and that this enables LMO2 to promote T-lymphoblastic leukemia.

• Publication year

  2023

• Venue

  Journal of Experimental Medicine

• Publication date

  2023-03-15

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1084/jem.20212383PMID 36920307PMCID 10037042
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

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