Design considerations for observational studies of drugs for advanced cancer

Key Points • Real-world evidence (RWE) studies are gaining relevance in the clinical development programmes of drugs for advanced cancer. • RWE studies of drugs for advanced cancer can be challenging because the study drug can be part of several of the many lines of treatment (LoTs) patients can receive, and occasionally, the component drugs of a LoT are not started concomitantly. • The target trial emulation framework can help in the design, analysis, and interpretation of RWE studies of drugs for advanced cancer.

• Publication year

  2023

• Venue

  Pharmacoepidemiology and Drug Safety

• Publication date

  2023-03-15

• Fields of study

  Medicine

• Identifiers
  DOI 10.1002/pds.5612PMID 36920321
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

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