Pyrrolidine Dithiocarbamate Activates p38 MAPK and Protects Brain Endothelial Cells From Apoptosis: A Mechanism for the Protective Effect in Stroke?

No abstract is available for this paper.

• Publication year

  2010

• Venue

  Neurochemical Research

• Publication date

  2010-06-01

• Fields of study

  Medicine, Environmental Science

• Identifiers
  DOI 10.1007/s11064-010-0197-0PMID 20514517
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

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  2009cited by this paper
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  2007cited by this paper
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  2007cited by this paper
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  2006cited by this paper
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  2006cited by this paper
• 1,026 Experimental treatments in acute stroke

  2006cited by this paper
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  2004influential reference
• Administration of the p38 MAPK inhibitor SB203580 affords brain protection with a wide therapeutic window against focal ischemic insult

  2003cited by this paper
• Carbon Monoxide Modulates Fas/Fas Ligand, Caspases, and Bcl-2 Family Proteins via the p38α Mitogen-activated Protein Kinase Pathway during Ischemia-Reperfusion Lung Injury*

  2003cited by this paper
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  2003cited by this paper
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  2003cited by this paper
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  2003cited by this paper
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  2003cited by this paper
• Signalling for survival and death in neurones: the role of stress-activated kinases, JNK and p38.

  2001cited by this paper
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  2001cited by this paper
• Inhibition of p38 mitogen‐activated protein kinase provides neuroprotection in cerebral focal ischemia

  2001cited by this paper
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  2001cited by this paper
• Programmed Cell Death in Cerebral Ischemia

  2001cited by this paper
• The p38 signal transduction pathway: activation and function.

  2000cited by this paper
• Multiple Molecular Penumbras after Focal Cerebral Ischemia

  2000cited by this paper
• Differential activation of MAPK/ERK and p38/SAPK in neurones and glia following focal cerebral ischaemia in the rat.

  2000cited by this paper
• Specificity and mechanism of action of some commonly used protein kinase inhibitors.

  2000cited by this paper
• NF-kappaB is activated and promotes cell death in focal cerebral ischemia.

  1999cited by this paper
• In utero gene therapy: The case for

  1999cited by this paper
• Tissue plasminogen activator for acute ischemic stroke.

  1996cited by this paper
• Tissue plasminogen activator for acute ischemic stroke. The National Institute of Neurological Disorders and Stroke rt-PA Stroke Study Group.

  1995cited by this paper
• Tissue plasminogen activator for acute ischemic stroke.

  1995cited by this paper
• Viability thresholds and the penumbra of focal ischemia

  1994cited by this paper
• Inhibition of HIV progression by dithiocarb. German DTC Study Group.

  1990cited by this paper

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