The nuclear cap-binding complex interacts with the U4/U6·U5 tri-snRNP and promotes spliceosome assembly in mammalian cells

This study investigates the mechanism by which the nuclear cap-binding complex (CBC) promotes splicing. The authors used mass spectrometry to identify proteins that interact with the CBC complex. A surprising observation is that CBC interacts more strongly with the tri-snRNP than the U1 snRNP. This paper shows that CBC promotes pre-mRNA splicing through a network of interactions with and among spliceosomal snRNPs during cotranscriptional spliceosome assembly.

• Publication year

  2013

• Venue

  RNA: A publication of the RNA Society

• Publication date

  2013-08-01

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1261/rna.037069.112PMID 23793891PMCID 3708526
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

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