Intrinsic theta oscillation in the attractor network of grid cells

Summary Both grid-like firing fields and theta oscillation are hallmarks of grid cells in the mammalian brain. While bump attractor dynamics have generally been recognized as the substrate for grid firing fields, how theta oscillation arises and interacts with persistent activity in a cortical circuit remains obscure. Here, we report that the theta oscillation intrinsically emerges in a continuous attractor network composed of principal neurons and interneurons. Periodic bump attractors and the theta rhythm stably coexist in both cell types due to the division of labor among interneurons via structured synaptic connectivity between principal cells and interneurons. The slow dynamics of NMDAR-mediated synaptic currents support the persistency of bump attractors and restrict the oscillation frequency in the theta band. The spikes of neurons within bump attractors are phase locked to a proxy of local field potential. The current work provides a network-level mechanism that orchestrates the bump attractor dynamics and theta rhythmicity.

• Publication year

  2023

• Venue

  iScience

• Publication date

  2023-03-01

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1016/j.isci.2023.106351PMID 37009231PMCID 10050492
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

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