A molecular characterization of the agonist binding site of a nematode cys‐loop GABA receptor

No abstract is available for this paper.

• Publication year

  2015

• Venue

  British Journal of Pharmacology

• Publication date

  2015-08-01

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1111/bph.13158PMID 25850584PMCID PMC4523332
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Caenorhabditis elegans Neuromuscular Junction: GABA Receptors and Ivermectin Action

  2014influential reference
• The IUPHAR/BPS Guide to PHARMACOLOGY: an expert-driven knowledgebase of drug targets and their ligands

  2013cited by this paper
• The Concise Guide to Pharmacology 2013/14: Ligand-Gated Ion Channels

  2013cited by this paper
• Structurally diverse GABA antagonists interact differently with open and closed conformational states of the ρ1 receptor.

  2012influential reference
• The pharmacological profile of ELIC, a prokaryotic GABA-gated receptor

  2012cited by this paper
• Nematode cys-loop GABA receptors: biological function, pharmacology and sites of action for anthelmintics

  2012cited by this paper
• GABA binding to an insect GABA receptor: a molecular dynamics and mutagenesis study.

  2012cited by this paper
• Differentiating enantioselective actions of GABOB: a possible role for threonine 244 in the binding site of GABA(C) ρ(1) receptors.

  2012influential reference
• ZINC: A Free Tool to Discover Chemistry for Biology

  2012cited by this paper
• The Haemonchus contortus UNC-49B subunit possesses the residues required for GABA sensitivity in homomeric and heteromeric channels.

  2011cited by this paper
• Principles of activation and permeation in an anion-selective Cys-loop receptor

  2011cited by this paper
• A Cation-π Interaction at a Phenylalanine Residue in the Glycine Receptor Binding Site Is Conserved for Different Agonists

  2011cited by this paper
• harmacological characterization of the Haemonchus contortus ABA-gated chloride channel , Hco-UNC-49 : Modulation by acrocyclic lactone anthelmintics and a receptor for piperazine avid

  2011cited by this paper
• Animal Research: Reporting In Vivo Experiments: The ARRIVE Guidelines

  2010cited by this paper
• An UNC‐49 GABA receptor subunit from the parasitic nematode Haemonchus contortus is associated with enhanced GABA sensitivity in nematode heteromeric channels

  2010cited by this paper
• Guidelines for reporting experiments involving animals: the ARRIVE guidelines

  2010cited by this paper
• Molecular Characterization of Agonists That Bind to an Insect GABA Receptor

  2010influential reference
• Guanidino Acids Act as ρ1 GABAC Receptor Antagonists

  2009cited by this paper
• AutoDock Vina: Improving the speed and accuracy of docking with a new scoring function, efficient optimization, and multithreading

  2009cited by this paper
• AutoDock4 and AutoDockTools4: Automated docking with selective receptor flexibility

  2009cited by this paper
• Enantioselective actions of 4-amino-3-hydroxybutanoic acid and (3-amino-2-hydroxypropyl)methylphosphinic acid at recombinant GABA(C) receptors.

  2008cited by this paper
• Clustal W and Clustal X version 2.0

  2007cited by this paper
• Locating the Carboxylate Group of GABA in the Homomeric rho GABAA Receptor Ligand-binding Pocket*

  2006cited by this paper
• The composition of the GABA receptor at the Caenorhabditis elegans neuromuscular junction

  2005cited by this paper
• An Arginine Involved in GABA Binding and Unbinding But Not Gating of the GABAA Receptor

  2004cited by this paper
• UCSF Chimera—A visualization system for exploratory research and analysis

  2004influential reference
• The GABA nervous system in C. elegans.

  2004cited by this paper
• EXP-1 is an excitatory GABA-gated cation channel

  2003cited by this paper
• Pharmacological characterization of the homomeric and heteromeric UNC‐49 GABA receptors in C. elegans

  2003influential reference
• Activation of GABA(A) receptors by guanidinoacetate: a novel pathophysiological mechanism.

  2002cited by this paper
• Taurine activates GABA(A) but not GABA(B) receptors in rat hippocampal CA1 area.

  2000cited by this paper
• One GABA and two acetylcholine receptors function at the C. elegans neuromuscular junction

  1999cited by this paper
• The Caenorhabditis elegans unc-49 Locus Encodes Multiple Subunits of a Heteromultimeric GABA Receptor

  1999cited by this paper
• avr‐15 encodes a chloride channel subunit that mediates inhibitory glutamatergic neurotransmission and ivermectin sensitivity in Caenorhabditis elegans

  1997cited by this paper
• Agonist pharmacology of two Drosophila GABA receptor splice variants

  1996influential reference
• Homomeric rho 1 GABA channels: activation properties and domains.

  1994cited by this paper
• GABAA receptor needs two homologous domains of the & beta;-subunit for activation by GABA but not by pentobarbital

  1993cited by this paper
• Characterization of bicuculline/baclofen-insensitive (rho-like) gamma-aminobutyric acid receptors expressed in Xenopus oocytes. II. Pharmacology of gamma-aminobutyric acidA and gamma-aminobutyric acidB receptor agonists and antagonists.

  1993cited by this paper
• Comparative protein modelling by satisfaction of spatial restraints.

  1993influential reference
• Genes required for GABA function in Caenorhabditis elegans

  1993cited by this paper
• Pharmacology of GABA rho 1 and GABA alpha/beta receptors expressed in Xenopus oocytes and COS cells.

  1993influential reference
• Neuromuscular transmission in nematode parasites and antinematodal drug action.

  1993cited by this paper
• Pharmacology of GAB A ρ1 and GAB A α/β receptors expressed in Xenopus oocytes and COS cells

  1993cited by this paper
• GABA receptors on the somatic muscle cells of the parasitic nematode, Ascaris suum: stereoselectivity indicates similarity to a GABAA‐type agonist recognition site

  1989influential reference
• Studies involving avermectin and the 4-aminobutyric acid (GABA) receptor of Ascaris suum muscle†

  1988influential reference
• ZAPA, (Z)‐3‐[(aminoiminomethyl)thio]‐2‐propenoic acid hydrochloride, a potent agonist at GABA‐receptors on the Ascaris muscle cell

  1988cited by this paper
• The electrophysiology of the somatic muscle cells of Ascaris suum and Ascaridia galli

  1987cited by this paper
• ELECTROPHYSIOLOGICAL EFFECTS OF PIPERAZINE AND DIETHYLCARBAMAZINE ON Ascaris suum SOMATIC MUSCLE

  1982cited by this paper
• Different efficacies of d- and l-gamma-amino-beta-hydroxybutyric acids in GABA receptor and transport test systems

  1981cited by this paper

• Widely targeted metabolomics analysis reveals the profiles of Vetch honey

  2025cites this paper
• Characterization of adjacent charged residues near the agonist binding site of the nematode UNC-49 GABA receptor.

  2022cites this paper
• Advances in our understanding of nematode ion channels as potential anthelmintic targets

  2021cites this paper
• Molecular cloning and pharmacology of Min-UNC-49B, a GABA receptor from the southern root-knot nematode Meloidogyne incognita.

  2020cites this paper
• Investigation of Agonist Recognition and Channel Properties in a Flatworm Glutamate-Gated Chloride Channel.

  2018cites this paper
• Molecular Characterization of Binding Loop E in the Nematode Cys-Loop GABA Receptor

  2018cites this paper
• A mutational and molecular dynamics study of the cys-loop GABA receptor Hco-UNC-49 from Haemonchus contortus: Agonist recognition in the nematode GABA receptor family

  2018cites this paper
• Isolation and partial characterization of three acetylcholine-gated chloride channels in Haemonchus contortus

  2017cites this paper
• Efficient synthesis of the GABAA receptor agonist trans-4-aminocrotonic acid (TACA).

  2017cites this paper
• Pharmacological characterization of the excitatory ‘Cys‐loop’ GABA receptor family in Caenorhabditis elegans

  2017influential citation
• Investigation into the role of binding loop E on the function of the nematode cys-loop GABA receptor.

  2014cites this paper