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Relationships between hormone levels, metabolism and immune response in toads from a semi-arid region.

Carla B. Madelaire,F. Gomes

Published 2023 in General and Comparative Endocrinology

ABSTRACT

Steroid hormones (e.g. androgens [AN] and corticosterone [CORT]) modulate complex physiological functions such as reproduction, energy mobilization, metabolism, and immunity. Fluctuations in environmental resource availability along with other factors, such as parasitism, can interact with the effects of these steroids, modifying aspects of immunocompetence and its metabolic costs. To understand these possible interactions, we studied AN and CORT, immune response [swelling response to phytohemagglutinin (PHA) injection and bacterial killing ability (BKA)], parasite load, resting metabolic rate (RMR) and rates of oxygen consumption after PHA injection, in two different phases of the annual cycle of a toad (Rhinella jimi) from a highly seasonal environment (Brazilian semi-arid, Caatinga). We observed increased rates of O2 consumption after both PHA and the control (saline) injection, indicating a metabolic response to adverse stimuli but not the immune challenge. Toads showing higher RMR and VO2 after the adverse stimuli (PHA/saline injection) had lower field AN and CORT plasma levels, suggesting these hormones might mediate a metabolic energy conservation strategy both at baseline levels and after adverse stimuli. Parasite load seem to impose an energetic constrain to the metabolic response to PHA and saline injection. Also, individuals showing higher PHA swelling response had higher field CORT plasma levels (particularly when males are breeding) which opposes the idea of a possible trade-off between reproductive activity and other physiological traits and indicate the immunoenhancing effects CORT elevated at physiological levels. BKA did not show a seasonal variation or correlation with body condition nor hormone levels, indicating that the immune surveillance mediated by the complement remains constant despite other ecological and physiological changes.

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