Acylsugar-mediated resistance as part of a multilayered defense against thrips, orthotospoviruses, and beyond.

Resistant varieties are critical tools for crop production, and single resistance genes providing strong protection against pests or pathogens are deployed in agriculture. Durability of these traits is threatened by emergence of resistance-breaking pests and pathogens. This review focuses on acylsugar-mediated resistance in tomato. Wild tomatoes have type IV trichomes that exude chemically complex mixtures of acylsugars altering behavior and suppressing multiple pest species, and with thrips and whiteflies, suppressing virus transmission, e.g., Tomato spotted wilt orthotospovirus and Tomato yellow leaf curl virus, respectively. Marker assisted selection and bioassays led to development of advanced cultivated tomato breeding lines rich in acylsugars variations, allowing acylsugar-mediated resistance to be combined with other resistance traits providing a layered defense system that reduces pest populations and virus disease prevalence. This strategy also holds promise for enhancing durability of virus resistance genes by reducing the intensity of selection for resistance-breaking variants.

• Publication year

  2023

• Venue

  Current Opinion in Insect Science

• Publication date

  2023-03-01

• Fields of study

  Biology, Agricultural and Food Sciences, Medicine, Environmental Science

• Identifiers
  DOI 10.1016/j.cois.2023.101021PMID 36925103
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

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  2005cited by this paper
• Plant responses to insect herbivory: the emerging molecular analysis.

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