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Relationship between muscle venous blood oxygenation and near-infrared spectroscopy: quantitative analysis of the Hb and Mb contributions.

B. Koirala,A. Concas,Yi Sun,L. Gladden,N. Lai

Published 2023 in Journal of applied physiology

ABSTRACT

A linear relationship between skeletal muscle venous (CTven) and oxygenated (ΔHbMbO2,N) or deoxygenated (ΔHHbMbN) near-infrared spectroscopy (NIRS) signal suggests a main Hb contribution to the NIRS signal. However, experimental, and computational evidence supports a significant contribution of Mb to the NIRS. Venous and NIRS measurements from a canine model of muscle oxidative metabolism (Med. Sci. Sports Exerc. 48(10):2013-2020, 2016) were integrated into a computational model of muscle O2 transport and utilization to evaluate whether the relationship between venous and NIRS oxygenation can be affected by a significant Mb contribution to the NIRS signals. The mathematical model predicted well the measure of the changes of CTven and NIRS signals for different O2 delivery (blood flow, arterial O2 content) in muscle at rest (T1, T2) and during contraction (T3). Furthermore, computational analysis indicates that for adequate O2 delivery, Mb contribution to NIRS signals was significant (20-30%) even in presence of a linear CTven-NIRS relationship; for a reduced O2 delivery the non-linearity of the CTven-NIRS relationship was related to the Mb contribution (50%). In this case (T3), the deviation from linearity is observed when O2 delivery is reduced from 1.3 to 0.7 L kg-1min-1 (CTven< 10 mLO2 100mL-1) and Mb saturation decreased from 85 to 40% corresponding to an increase of the Mb contribution to ΔHHbMbN from 15 to 50% and the contribution to ΔHbMbO2,N from 0% to 30%. In contrast to a common assumption, our model indicates that both NIRS signals (ΔHbMbO2,N, ΔHHbMbN) are significantly affected by Hb and Mb oxygenation changes.

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