‘On Water’‐Promoted Three‐Component Tandem Michael Addition/D−A Cycloaddition Reaction to Construct Polycyclic N‐Heterocycles Derivatives

‘On Water’‐promoted the three‐component tandem Michael addition/D−A cycloaddition reaction in 80 °C at 3 h has been developed without employing any catalyst and organic solvent. The process allows facile access to polycyclic N‐heterocycles derivatives contain indole and maleimide from easily accessible starting materials in moderate to high yields (up to 91 %). Compared with conventional reaction conditions, this reaction not only improves the reaction efficiency and rate but also minimizes the side reaction.

• Publication year

  2023

• Venue

  Chemistry and Biodiversity

• Publication date

  2023-03-17

• Fields of study

  Medicine, Chemistry

• Identifiers
  DOI 10.1002/cbdv.202300100PMID 36930226
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

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