Antiglaucomatous effects of the activation of intrinsic Angiotensin-converting enzyme 2.

No abstract is available for this paper.

• Publication year

  2013

• Venue

  Investigative Ophthalmology and Visual Science

• Publication date

  2013-06-21

• Fields of study

  Medicine

• Identifiers
  DOI 10.1167/iovs.12-11427PMID 23702784PMCID PMC3739491
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Oral administration of an angiotensin-converting enzyme 2 activator ameliorates diabetes-induced cardiac dysfunction.

  2012cited by this paper
• Therapeutic targeting of the angiotensin-converting enzyme 2/Angiotensin-(1-7)/Mas cascade in the renin–angiotensin system: a patent review

  2012cited by this paper
• Prediction of Off-Target Effects on Angiotensin-Converting Enzyme 2

  2011cited by this paper
• Angiotensin‐converting enzyme 2 activation protects against hypertension‐induced cardiac fibrosis involving extracellular signal‐regulated kinases

  2011cited by this paper
• Rodent models of glaucoma.

  2010influential reference
• Angiotensin receptors in the eyes of arterial hypertensive rats

  2009influential reference
• Activities of Angiotensin-Converting Enzymes ACE1 and ACE2 and Inhibition by Bioactive Peptides in Porcine Ocular Tissues

  2009cited by this paper
• Angiotensin (1-7) reduces intraocular pressure in the normotensive rabbit eye.

  2008cited by this paper
• Scintigraphic imaging using technetium-99m-labeled ceftizoxime in an experimental model of acute osteomyelitis in rats

  2008cited by this paper
• Recent advances in the angiotensin‐converting enzyme 2–angiotensin(1–7)–Mas axis

  2008cited by this paper
• Rodent Models for Glaucoma Retinopathy and Optic Neuropathy

  2007influential reference
• Angiotensin II and its receptor subtypes in the human retina.

  2007cited by this paper
• Angiotensin-converting enzyme 2 and angiotensin-(1-7): an evolving story in cardiovascular regulation.

  2006cited by this paper
• Genetic polymorphisms in the angiotensin II receptor gene and their association with open-angle glaucoma in a Japanese population.

  2005cited by this paper
• A new experimental model of glaucoma in rats through intracameral injections of hyaluronic acid.

  2005cited by this paper
• Cardiovascular actions of angiotensin-(1-7).

  2005cited by this paper
• G-Protein–Coupled Receptor Mas Is a Physiological Antagonist of the Angiotensin II Type 1 Receptor

  2005cited by this paper
• Immunohistochemical Localization of Angiotensin-Converting Enzyme, Angiotensin II and AT1 Receptor in Human Ocular Tissues

  2004cited by this paper
• Identification of angiotensin converting enzyme 2 in the rodent retina

  2004cited by this paper
• Update on the ocular manifestations of systemic arterial hypertension

  2004influential reference
• Expression of an angiotensin-(1-7)-producing fusion protein produces cardioprotective effects in rats.

  2004cited by this paper
• Angiotensin-(1–7) is an endogenous ligand for the G protein-coupled receptor Mas

  2003cited by this paper
• A Novel Angiotensin-Converting Enzyme–Related Carboxypeptidase (ACE2) Converts Angiotensin I to Angiotensin 1-9

  2000cited by this paper
• Oculohypotensive effect of angiotensin-converting enzyme inhibitors in acute and chronic models of glaucoma.

  2000cited by this paper
• Angiotensin-(1-7): an update.

  2000cited by this paper
• A Human Homolog of Angiotensin-converting Enzyme

  2000cited by this paper
• Vascular risk factors for primary open angle glaucoma: the Egna-Neumarkt Study.

  2000cited by this paper
• Nitric oxide: a potential mediator of retinal ganglion cell damage in glaucoma.

  1999cited by this paper
• Apoptosis of retinal ganglion cells in glaucoma: an update of the molecular pathways involved in cell death.

  1999cited by this paper
• The role of neuronal and endothelial nitric oxide synthase in retinal excitotoxicity.

  1997cited by this paper
• Apoptosis in retinal ganglion cell decrease in human glaucomatous eyes.

  1997cited by this paper
• Demonstration of renin mRNA, angiotensinogen mRNA, and angiotensin converting enzyme mRNA expression in the human eye: evidence for an intraocular renin-angiotensin system.

  1996cited by this paper
• Identification of an extensive system of nitric oxide-producing cells in the ciliary muscle and outflow pathway of the human eye.

  1995cited by this paper
• Angiotensin levels in the eye.

  1994cited by this paper
• Ophthalmic artery flow velocity in glaucomatous and normal subjects.

  1993cited by this paper

• Revisiting the renin-angiotensin-aldosterone system in the eye: mechanistic insights and pharmacological targets.

  2025cites this paper
• Mechanobiology in the eye

  2025cites this paper
• Ocular neuroinflammatory response secondary to SARS-CoV-2 infection-a review

  2025cites this paper
• Mendelian randomization supports causality between COVID-19 and glaucoma

  2024cites this paper
• Glaucoma and the ocular renin-angiotensin-aldosterone system: Update on molecular signalling and treatment perspectives.

  2024cites this paper
• Diminazene aceturate‐induced cytotoxicity is associated with the deregulation of cell cycle signaling and downregulation of oncogenes Furin, c‐MYC, and FOXM1 in human cervical carcinoma Hela cells

  2023cites this paper
• Identifying new drugs and targets to treat rapidly elevated intraocular pressure for angle closure and secondary glaucomas to curb visual impairment.

  2023cites this paper
• Co-occurrence of chronic kidney disease and glaucoma: Epidemiology and etiological mechanisms.

  2022cites this paper
• Molecular imaging on ACE2‐dependent transocular infection of coronavirus

  2022cites this paper
• Is Diminazene an Angiotensin-Converting Enzyme 2 (ACE2) Activator? Experimental Evidence and Implications

  2022influential citation
• Evaluation of the non-clinical toxicity of an antiparasitic agent: diminazene aceturate

  2021cites this paper
• Therapeutic Drugs and Devices for Tackling Ocular Hypertension and Glaucoma, and Need for Neuroprotection and Cytoprotective Therapies

  2021cites this paper
• Pulmonary fibrosing diseases: A short review and a therapeutic alternative

  2021cites this paper
• Emerging importance of ACE2 in external stratified epithelial tissues

  2021cites this paper
• Update on New Aspects of the Renin-Angiotensin System in Hepatic Fibrosis and Portal Hypertension: Implications for Novel Therapeutic Options

  2021cites this paper
• New antiglaucomatous agent for the treatment of open angle glaucoma: polymeric inserts for drug release and in vitro and in vivo study.

  2020cites this paper
• An update on ACE2 amplification and its therapeutic potential

  2020cites this paper
• Expression of SARS-CoV-2 receptor ACE2 and TMPRSS2 in human primary conjunctival and pterygium cell lines and in mouse cornea

  2020cites this paper
• Therapeutic effects of various renin angiotensin modulators on hyperglycemia-induced cataract formation in Sprague Dawley rats

  2020cites this paper
• Brain angiotensin converting enzyme-2 in central cardiovascular regulation.

  2020cites this paper
• SARS-CoV-2 on the ocular surface: is it truly a novel transmission route?

  2020cites this paper
• Aqueous humor renin, angiotensin I, and angiotensin II activity in primary open-angle glaucoma

  2020cites this paper
• Potential neuroinvasive pathways of SARS‐CoV‐2: Deciphering the spectrum of neurological deficit seen in coronavirus disease‐2019 (COVID‐19)

  2020cites this paper
• Current Evidence of 2019 Novel Coronavirus Disease (COVID-19) Ocular Transmission: A Systematic Review and Meta-Analysis

  2020cites this paper
• Chitosan/Hydroxyethyl cellulose inserts for sustained-release of dorzolamide for glaucoma treatment: in vitro and in vivo evaluation.

  2019cites this paper
• Angiotensin II and aldosterone in retinal vasculopathy and inflammation.

  2019cites this paper
• Neuroprotective Peptides in Retinal Disease

  2019cites this paper
• Novel Therapeutic Targets for Glaucoma: Disease Modification Treatment, Neuroprotection, and Neuroregeneration

  2019cites this paper
• Relationships Between Neurodegeneration and Vascular Damage in Diabetic Retinopathy

  2019cites this paper
• Tools for Studying Angiotensin-(1-7)

  2019cites this paper
• β-Cyclodextrin as a Functional Excipient Used for Enhancing the Diminazene Aceturate Bioavailability

  2019cites this paper
• Retinal Renin-Angiotensin System Modulators: A Recent Implication for Therapy in Glaucomatous Patients

  2018cites this paper
• iDrugs and iDevices Discovery Research: Preclinical Assays, Techniques, and Animal Model Studies for Ocular Hypotensives and Neuroprotectants

  2018cites this paper
• Four decades of ocular renin‐angiotensin and kallikrein‐kinin systems (1977–2017)

  2018cites this paper
• Therapeutic treatment of Zika virus infection using a brain-penetrating antiviral peptide

  2018cites this paper
• Original Research: ACE2 activator associated with physical exercise potentiates the reduction of pulmonary fibrosis

  2017cites this paper
• Overexpression of Angiotensin-Converting Enzyme 2 Ameliorates Amyloid β-Induced Inflammatory Response in Human Primary Retinal Pigment Epithelium.

  2017cites this paper
• Prospects of Treating Ocular Hypertension and Glaucoma with Peptidic and Non-Peptide Kinin Mimetic Drugs

  2017cites this paper
• Ocular Hypertension and Glaucoma: A Review and Current Perspectives

  2017cites this paper
• Significance of angiotensin 1–7 coupling with MAS1 receptor and other GPCRs to the renin‐angiotensin system: IUPHAR Review 22

  2017cites this paper
• Sustained drug delivery for the management of glaucoma

  2017cites this paper
• Many Faces of Renin-angiotensin System - Focus on Eye

  2017cites this paper
• The ACE2/Angiotensin-(1–7)/MAS Axis of the Renin-Angiotensin System: Focus on Angiotensin-(1–7)

  2017cites this paper
• N-Methyl-d-Aspartate (NMDA) Receptor Blockade Prevents Neuronal Death Induced by Zika Virus Infection

  2017cites this paper
• Principles of Ocular Pharmacology

  2016cites this paper
• Localization and function of AT1 and MAS in porcine retinal arteries

  2016cites this paper
• Renin-angiotensin system as a potential therapeutic target in stroke and retinopathy: experimental and clinical evidence.

  2016cites this paper
• Molecular regulation of Trypanosoma congolense-induced proinflammatory cytokine production in macrophages and its modulation by diminazene aceturate (Berenil)

  2016cites this paper
• Cardioprotective effects of diminazene aceturate in pressure-overloaded rat hearts.

  2016cites this paper
• Neuropathy optic glaucomatosa induced by systemic hypertension through activation endothelin-1 signaling pathway in central retinal artery in rats.

  2016cites this paper
• One protein, multiple pathologies: multifaceted involvement of amyloid β in neurodegenerative disorders of the brain and retina

  2016cites this paper
• Therapeutic uses for Angiotensin-(1-7)

  2016cites this paper
• AAV8-Mediated Angiotensin-Converting Enzyme 2 Gene Delivery Prevents Experimental Autoimmune Uveitis by Regulating MAPK, NF-κB and STAT3 Pathways

  2016cites this paper
• Angiotensin converting enzyme 2 and diminazene: role in cardiovascular and blood pressure regulation

  2016cites this paper
• Anti-hypertensive Effects of Diminazene Aceturate: An Angiotensin- Converting Enzyme 2 Activator in Rats.

  2015cites this paper
• Novel Potential Treatment Modalities for Ocular Hypertension: Focus on Angiotensin and Bradykinin System Axes

  2015cites this paper
• Ocular renin-angiotensin system with special reference in the anterior part of the eye

  2015cites this paper
• Diminazene aceturate--An antiparasitic drug of antiquity: Advances in pharmacology & therapeutics.

  2015cites this paper
• Ocular Inserts for Sustained Release of the Angiotensin-Converting Enzyme 2 Activator, Diminazene Aceturate, to Treat Glaucoma in Rats

  2015cites this paper
• Activation of endogenous angiotensin converting enzyme 2 prevents early injuries induced by hyperglycemia in rat retina

  2015cites this paper
• Diminazene protects corpus cavernosum against hypercholesterolemia-induced injury.

  2015cites this paper
• Development of a cell-based intraocular deliverysystem for neurotrophic factors to attenuate retinalganglion cell loss in a mouse model of glaucoma

  2015cites this paper
• The expression of Mas-receptor of the renin–angiotensin system in the human eye

  2015cites this paper
• Angiotensins as therapeutic targets beyond heart disease.

  2015cites this paper
• Angiotensin converting enzyme 2 activator (DIZE) modulates metabolic profiles in mice, decreasing lipogenesis.

  2015cites this paper
• Diminazene enhances stability of atherosclerotic plaques in ApoE-deficient mice.

  2015cites this paper
• Angiotensin-Converting Enzyme 2–Independent Action of Presumed Angiotensin-Converting Enzyme 2 Activators: Studies In Vivo, Ex Vivo, and In Vitro

  2014cites this paper
• Diminazene aceturate (Berenil), a new use for an old compound?

  2014cites this paper
• Activation of angiotensin-converting enzyme 2 improves cardiac electrical changes in ventricular repolarization in streptozotocin-induced hyperglycaemic rats.

  2014cites this paper
• Angiotensin-Converting Enzyme 2 Decreases Formation and Severity of Angiotensin II–Induced Abdominal Aortic Aneurysms

  2014cites this paper
• Autoregulation of optic nerve head blood flow and its role in open-angle glaucoma

  2014cites this paper
• Angiotensin-converting enzyme 2 (ACE2) activator diminazene aceturate ameliorates endotoxin-induced uveitis in mice.

  2014cites this paper
• Retina Angiotensin-Converting Enzyme 2 ( ACE 2 ) Activator Diminazene Aceturate Ameliorates Endotoxin-Induced Uveitis in Mice

  2014cites this paper
• Angiotensin-Converting Enzyme 2: Potential Target for the Development of Novel Ocular Therapies

  2014cites this paper
• The Microfibril Hypothesis of Glaucoma: Implications for Treatment of Elevated Intraocular Pressure

  2014cites this paper
• Some non-conventional biomolecular targets for diamidines. A short survey.

  2014cites this paper