A review on surgical treatment options in gliomas

Gliomas are one of the most common primary central nervous system tumors, and surgical treatment remains the principal role in the management of any grade of gliomas. In this study, based on the introduction of gliomas, we review the novel surgical techniques and technologies in support of the extent of resection to achieve long-term disease control and summarize the findings on how to keep the balance between cytoreduction and neurological morbidity from a list of literature searched. With modern neurosurgical techniques, gliomas resection can be safely performed with low morbidity and extraordinary long-term functional outcomes.

• Publication year

  2023

• Venue

  Frontiers in Oncology

• Publication date

  2023-03-16

• Fields of study

  Medicine

• Identifiers
  DOI 10.3389/fonc.2023.1088484PMID 37007123PMCID 10061125
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Intraoperative ultrasound in brain tumor surgery: A review and implementation guide

  2022cited by this paper
• Intraoperative imaging technology to maximise extent of resection for glioma: a network meta-analysis.

  2021cited by this paper
• Supratentorial high-grade gliomas: maximal safe anatomical resection guided by augmented reality high-definition fiber tractography and fluorescein.

  2021cited by this paper
• Application of Multiparametric Intraoperative Ultrasound in Glioma Surgery

  2021cited by this paper
• Intraoperative MR Imaging during Glioma Resection

  2021cited by this paper
• Intraoperative Cognitive Mapping Tasks for Direct Electrical Stimulation in Clinical and Neuroscientific Contexts

  2021cited by this paper
• Awake vs. asleep motor mapping for glioma resection: a systematic review and meta-analysis

  2020cited by this paper
• Tractography and the connectome in neurosurgical treatment of gliomas: the premise, the progress, and the potential.

  2020cited by this paper
• Experience Profiling of Fluorescence-Guided Surgery I: Gliomas

  2019cited by this paper
• Intraoperative clinical application of augmented reality in neurosurgery: A systematic review.

  2019cited by this paper
• Letter: Introducing New Tasks for Intraoperative Mapping in Awake Glioma Surgery: Clearing the Line Between Patient Care and Scientific Research.

  2019cited by this paper
• High-field intraoperative MRI and glioma surgery: results after the first 100 consecutive patients

  2019cited by this paper
• Prevalence of symptoms in glioma patients throughout the disease trajectory: a systematic review

  2018cited by this paper
• Network meta-analysis.

  2017cited by this paper
• Beyond the margins: real-time detection of cancer using targeted fluorophores

  2017cited by this paper
• An extent of resection threshold for seizure freedom in patients with low-grade gliomas.

  2017cited by this paper
• Intraoperative MRI for the management of brain lesions adjacent to eloquent areas.

  2017cited by this paper
• Advances in the molecular genetics of gliomas — implications for classification and therapy

  2017cited by this paper
• Barriers and facilitators related to the implementation of a physiological track and trigger system: A systematic review of the qualitative evidence

  2017cited by this paper
• Systematic review and meta-analysis.

  2017cited by this paper
• The influence of maximum safe resection of glioblastoma on survival in 1229 patients: Can we do better than gross-total resection?

  2016cited by this paper
• Cancer statistics in China, 2015

  2016cited by this paper
• Comparison between resting state fMRI networks and responsive cortical stimulations in glioma patients

  2016cited by this paper
• Merits and Limits of Tractography Techniques for the Uninitiated.

  2016cited by this paper
• Association of the Extent of Resection With Survival in Glioblastoma: A Systematic Review and Meta-analysis.

  2016cited by this paper
• Supratentorial hemispheric ependymomas: an analysis of 109 adults for survival and prognostic factors.

  2016cited by this paper
• Randomized controlled trial

  2016cited by this paper
• Stimulation mapping of white matter tracts to study brain functional connectivity

  2015cited by this paper
• Frontal operculum gliomas: language outcome following resection.

  2015cited by this paper
• Location of brain tumor intersecting white matter tracts predicts patient prognosis

  2015cited by this paper
• The Value of Pre- and Intraoperative Adjuncts on the Extent of Resection of Hemispheric Low-Grade Gliomas: A Retrospective Analysis

  2015cited by this paper
• Epidemiology of gliomas.

  2015cited by this paper
• Role of neurochemical navigation with 5-aminolevulinic acid during intraoperative MRI-guided resection of intracranial malignant gliomas.

  2015cited by this paper
• New Approach for Exploring Cerebral Functional Connectivity: Review of Cortico-cortical Evoked Potential

  2015cited by this paper
• Outcomes in Reoperated Low-Grade Gliomas.

  2015cited by this paper
• The epidemiology of glioma in adults: a "state of the science" review.

  2015cited by this paper
• Awake craniotomy to maximize glioma resection: methods and technical nuances over a 27-year period.

  2015cited by this paper
• Survival and low-grade glioma: the emergence of genetic information.

  2015cited by this paper
• Is fluorescein-guided technique able to help in resection of high-grade gliomas?

  2014cited by this paper
• The dangers of magnetic resonance imaging diffusion tensor tractography in brain surgery.

  2014cited by this paper
• Use of high-field intraoperative magnetic resonance imaging to enhance the extent of resection of enhancing and nonenhancing gliomas.

  2014cited by this paper
• 5-Aminolevulinic Acid Fluorescence in High Grade Glioma Surgery: Surgical Outcome, Intraoperative Findings, and Fluorescence Patterns

  2014cited by this paper
• Seizure prognosis in brain tumors: new insights and evidence-based management.

  2014cited by this paper
• Rapid and sensitive intraoperative detection of mutations in the isocitrate dehydrogenase 1 and 2 genes during surgery for glioma.

  2014cited by this paper
• The epidemiology of glioma in adults: a "state of the science" review.

  2014cited by this paper
• Establishing percent resection and residual volume thresholds affecting survival and recurrence for patients with newly diagnosed intracranial glioblastoma.

  2014cited by this paper
• Tumor detection with 5-aminolevulinic acid fluorescence and Gd-DTPA-enhanced intraoperative MRI at the border of contrast-enhancing lesions: a prospective study based on histopathological assessment.

  2014cited by this paper
• an update on

  2014cited by this paper
• An extent of resection threshold for recurrent glioblastoma and its risk for neurological morbidity.

  2014cited by this paper
• Gliomas

  2014cited by this paper
• Easy-to-Use Augmented Reality Neuronavigation Using a Wireless Tablet PC

  2013cited by this paper
• Management and survival rates in patients with glioma in China (2004–2010): a retrospective study from a single-institution

  2013cited by this paper
• Ambient mass spectrometry for the intraoperative molecular diagnosis of human brain tumors

  2013cited by this paper
• A novel augmented reality system of image projection for image-guided neurosurgery

  2013cited by this paper
• Recovery of White Matter Tracts in Regions of Peritumoral FLAIR Hyperintensity with Use of Restriction Spectrum Imaging

  2013cited by this paper
• 5-aminolevulinic acid and neuronavigation in high-grade glioma surgery: results of a combined approach.

  2012cited by this paper
• Impact of intraoperative stimulation brain mapping on glioma surgery outcome: a meta-analysis.

  2012cited by this paper
• Comparison of a strategy favoring early surgical resection vs a strategy favoring watchful waiting in low-grade gliomas.

  2012cited by this paper
• Coregistered fluorescence-enhanced tumor resection of malignant glioma: relationships between δ-aminolevulinic acid-induced protoporphyrin IX fluorescence, magnetic resonance imaging enhancement, and neuropathological parameters. Clinical article.

  2011cited by this paper
• Intraoperative Confocal Microscopy for Brain Tumors: A Feasibility Analysis in Humans

  2011cited by this paper
• Quantification of Glioma Removal by Intraoperative High-Field Magnetic Resonance Imaging: An Update

  2011cited by this paper
• An extent of resection threshold for newly diagnosed glioblastomas.

  2011cited by this paper
• Intraoperative confocal microscopy in the visualization of 5-aminolevulinic acid fluorescence in low-grade gliomas.

  2011cited by this paper
• Intraoperative MRI-guided resection of glioblastoma multiforme: a systematic review.

  2011cited by this paper
• Counterbalancing risks and gains from extended resections in malignant glioma surgery: a supplemental analysis from the randomized 5-aminolevulinic acid glioma resection study

  2011cited by this paper
• Counterbalancing risks and gains from extended resections in malignant glioma surgery: a supplemental analysis from the randomized 5-aminolevulinic acid glioma resection study. Clinical article.

  2011cited by this paper
• Low-grade gliomas in adults.

  2011cited by this paper
• Neuropeptides and animal modeling : from pathophysiological mechanisms to therapeutic applications

  2011cited by this paper
• First intraoperative, shared-resource, ultrahigh-field 3-Tesla magnetic resonance imaging system and its application in low-grade glioma resection.

  2010cited by this paper
• Reliability of intraoperative high-resolution 2D ultrasound as an alternative to high-field strength MR imaging for tumor resection control: a prospective comparative study.

  2009cited by this paper
• A Meta-Analysis

  2009cited by this paper
• Descriptive Epidemiology of Cerebral Gliomas in Northwest Greece and Study of Potential Predisposing Factors, 2005–2007

  2009cited by this paper
• EXTENT OF RESECTION AND SURVIVAL IN GLIOBLASTOMA MULTIFORME: IDENTIFICATION OF AND ADJUSTMENT FOR BIAS

  2008cited by this paper
• GLIOMA EXTENT OF RESECTION AND ITS IMPACT ON PATIENT OUTCOME

  2008cited by this paper
• The 2007 WHO Classification of Tumours of the Central Nervous System

  2007cited by this paper
• Incidence of gliomas by anatomic location.

  2007cited by this paper
• CLINICAL EVALUATION AND FOLLOW‐UP OUTCOME OF DIFFUSION TENSOR IMAGING‐BASED FUNCTIONAL NEURONAVIGATION: A PROSPECTIVE, CONTROLLED STUDY IN PATIENTS WITH GLIOMAS INVOLVING PYRAMIDAL TRACTS

  2007cited by this paper
• Quantitative spectroscopic analysis of 5-aminolevulinic acid-induced protoporphyrin IX fluorescence intensity in diffusely infiltrating astrocytomas.

  2007cited by this paper
• Brain plasticity: from pathophysiological mechanisms to therapeutic applications.

  2006cited by this paper
• Fluorescence-guided surgery with 5-aminolevulinic acid for resection of malignant glioma: a randomised controlled multicentre phase III trial.

  2006cited by this paper
• Performance measurement in healthcare: part I--concepts and trends from a State of the Science Review.

  2006cited by this paper
• Effectiveness of neuronavigation in resecting solitary intracerebral contrast-enhancing tumors: a randomized controlled trial.

  2006cited by this paper
• Long-Term Follow-up for Brain Tumor Development after Childhood Exposure to Ionizing Radiation for Tinea Capitis

  2005cited by this paper
• Sequential Visualization of Brain and Fiber Tract Deformation during Intracranial Surgery with Three-dimensional Ultrasound: An Approach to Evaluate the Effect of Brain Shift

  2005cited by this paper
• Specific intensity imaging for glioblastoma and neural cell cultures with 5-aminolevulinic acid-derived protoporphyrin IX

  2004cited by this paper
• Tumors of the nervous system and pituitary gland associated with atomic bomb radiation exposure.

  2002cited by this paper
• Localisation of the sensorimotor cortex during surgery for brain tumours: feasibility and waveform patterns of somatosensory evoked potentials

  2002cited by this paper
• Intraoperative detection of malignant gliomas by 5-aminolevulinic acid-induced porphyrin fluorescence.

  1998cited by this paper
• Individual functional anatomy of verb generation.

  1996cited by this paper
• Functional cortex and subcortical white matter located within gliomas.

  1996cited by this paper
• A Retrospective Analysis

  1990cited by this paper
• Supratentorial low-grade gliomas.

  1990cited by this paper
• The classification of tumours of the central nervous system.

  1982influential reference

• Optic Pathway Glioma: Current Treatment Approaches and Ongoing Clinical Trials

  2025cites this paper
• Identification of the high-risk population facing early death in older patients with primary intracranial glioma: a retrospective cohort study

  2025cites this paper
• Chordoid glioma of right lateral ventricle in young male: a case report

  2025cites this paper
• An integrated sensor system based on the phenomenon of surface plasmon resonance for early diagnosis of postoperative progression of malignant brain tumors

  2025cites this paper
• Prospects and applications of NK therapy in the treatment of gliomas (Review)

  2025cites this paper
• Immuno-oncological interactions between meningeal lymphatics and glioblastoma: from mechanisms to therapies

  2025cites this paper
• Comparison of utilizing a hypertonic saline solution and mannitol to improve brain relaxation during craniotomy in patients with brain tumours: a prospective randomized controlled trial

  2025cites this paper
• Challenges and material innovations in drug delivery to central nervous system tumors.

  2025cites this paper
• Gene Expression of GABAA Receptor Subunits and Association with Patient Survival in Glioma

  2024cites this paper
• Mass spectrometry for neurosurgery: Intraoperative support in decision-making.

  2024cites this paper
• Preliminary investigation of nitric oxide release from upconverted nanoparticles excited at 808 nm near-infrared for brain tumors

  2024cites this paper
• RETRACTED ARTICLE: Using AI to navigate complex neurosurgical procedures in rare gliomas

  2024cites this paper
• Risk factors for surgical compliance and impact on the survival of patients with glioma: a population-based propensity score-matched study

  2023cites this paper
• Sensors An integrated sensor system based on the phenomenon of surface plasmon resonance for early diagnosis of postoperative progression of malignant brain tumors

  year unknowncites this paper