Inhibitory effects of interferons on pancreatic stellate cell activation.

No abstract is available for this paper.

• Publication year

  2006

• Venue

  World Journal of Gastroenterology

• Publication date

  2006-02-14

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.3748/WJG.V12.I6.896PMID 16521217PMCID PMC4066154
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Interferon-gamma acts proapoptotic on hepatic stellate cells (HSC) and abrogates the antiapoptotic effect of interferon-alpha by an HSP70-dependant pathway.

  2005cited by this paper
• Inhibition of lymphocyte apoptosis by pancreatic stellate cells: impact of interleukin-15.

  2005cited by this paper
• Pancreatic carcinoma cells induce fibrosis by stimulating proliferation and matrix synthesis of stellate cells.

  2005cited by this paper
• Desmoplastic Reaction in Pancreatic Cancer: Role of Pancreatic Stellate Cells

  2004cited by this paper
• A c-Jun NH2-Terminal Kinase Inhibitor SP600125 (Anthra[1,9-cd]pyrazole-6 (2H)-one) Blocks Activation of Pancreatic Stellate Cells

  2004cited by this paper
• Hepatitis C and liver fibrosis

  2003cited by this paper
• Pancreatic Stellate Cell Activation by Ethanol and Acetaldehyde: Is it Mediated by the Mitogen-Activated Protein Kinase Signaling Pathway?

  2003cited by this paper
• Regulation of pancreatic stellate cell function in vitro: biological and molecular effects of all-trans retinoic acid.

  2003cited by this paper
• Inhibition of pancreatic stellate cell activation by the hydroxymethylglutaryl coenzyme A reductase inhibitor lovastatin.

  2003cited by this paper
• Stellate Cell Activation in Alcoholic Pancreatitis

  2003cited by this paper
• Inhibition of p38 Mitogen-Activated Protein Kinase Blocks Activation of Rat Pancreatic Stellate Cells

  2003cited by this paper
• Different effects of rat interferon alpha, beta and gamma on rat hepatic stellate cell proliferation and activation

  2002cited by this paper
• Extracellular signal regulated kinases are key mediators of mitogenic signals in rat pancreatic stellate cells

  2002cited by this paper
• Pancreatic stellate cells respond to inflammatory cytokines: potential role in chronic pancreatitis

  2002cited by this paper
• Alcohol activates activator protein-1 and mitogen-activated protein kinases in rat pancreatic stellate cells.

  2002cited by this paper
• Chronic pancreatitis: diagnosis, classification, and new genetic developments.

  2001cited by this paper
• Therapeutic advances in the management of hepatitis B and hepatitis C

  2001cited by this paper
• TGFβ1 autocrine growth control in isolated pancreatic fibroblastoid cells/stellate cells in vitro

  2000cited by this paper
• Janus kinases: components of multiple signaling pathways

  2000cited by this paper
• Does alcohol directly stimulate pancreatic fibrogenesis? Studies with rat pancreatic stellate cells.

  2000cited by this paper
• Platelet-Derived Growth Factors Stimulate Proliferation and Extracellular Matrix Synthesis of Pancreatic Stellate Cells: Implications in Pathogenesis of Pancreas Fibrosis

  2000cited by this paper
• Pancreatic stellate cells are activated by proinflammatory cytokines: implications for pancreatic fibrogenesis

  1999cited by this paper
• Activation of pancreatic stellate cells in human and experimental pancreatic fibrosis.

  1999cited by this paper
• Periacinar stellate shaped cells in rat pancreas: identification, isolation, and culture

  1998cited by this paper
• How cells respond to interferons.

  1998influential reference
• Identification, culture, and characterization of pancreatic stellate cells in rats and humans.

  1998cited by this paper
• Interferon gamma decreases hepatic stellate cell activation and extracellular matrix deposition in rat liver fibrosis

  1996cited by this paper
• Targeted disruption of the Stat1 gene in mice reveals unexpected physiologic specificity in the JAK-STAT signaling pathway.

  1996cited by this paper
• Targeted disruption of the mouse Stat1 gene results in compromised innate immunity to viral disease.

  1996cited by this paper
• Cytokine receptor signalling

  1995cited by this paper
• Molecular mechanisms of liver fibrogenesis--a homage to the role of activated fat-storing cells.

  1995cited by this paper
• Alpha and beta interferons and their receptor and their friends and relations.

  1995cited by this paper
• α and α Interferons and Their Receptor and Their Friends and Relations

  1995cited by this paper
• Pathology and pathogenesis of diseases of the pancreas.

  1982cited by this paper

• YAP activates pancreatic stellate cells and enhances pancreatic fibrosis.

  2022cites this paper
• MIF confers survival advantage to pancreatic CAFs by suppressing interferon pathway‐induced p53‐dependent apoptosis

  2022cites this paper
• Molecular mechanisms of pancreatic myofibroblast activation in chronic pancreatitis and pancreatic ductal adenocarcinoma

  2021cites this paper
• In cardiac fibroblasts, interferon-beta attenuates differentiation, collagen synthesis, and TGF-β1-induced collagen gel contraction.

  2020cites this paper
• Pancreatic Stellate Cells: The Key Orchestrator of The Pancreatic Tumor Microenvironment.

  2020cites this paper
• Potential therapeutic manipulations of the CXCR3 chemokine axis for the treatment of inflammatory fibrosing diseases

  2020cites this paper
• Role of Endothelin Axis in Pancreatic Tumor Microenvironment

  2017cites this paper
• Pancreatic stellate cell: Pandora's box for pancreatic disease biology

  2017cites this paper
• Effects of Low Intensity Continuous Ultrasound (LICU) on Mouse Pancreatic Tumor Explants

  2017cites this paper
• Novel and Experimental Therapies in Chronic Pancreatitis

  2017cites this paper
• Distinct antifibrogenic effects of erlotinib, sunitinib and sorafenib on rat pancreatic stellate cells.

  2014cites this paper
• Parameter Identifiability and Sensitivity Analysis Predict Targets for Enhancement of STAT1 Activity in Pancreatic Cancer and Stellate Cells

  2012cites this paper
• Studies on mechanisms of interferon-gamma action in pancreatic cancer using a data-driven and model-based approach

  2011cites this paper
• Pancreatic Cancer: The Role of Pancreatic Stellate Cells in Tumor Progression

  2011cites this paper
• Chronic pancreatitis: potential future interventions

  2010cites this paper
• Mathematical modelling of interferon-gamma signalling in pancreatic stellate cells reflects and predicts the dynamics of STAT1 pathway activity.

  2010cites this paper
• Signal transduction in pancreatic stellate cells

  2009cites this paper
• Molecular determinants of the profibrogenic effects of endothelin-1 in pancreatic stellate cells.

  2009cites this paper
• Interferon-Gamma Treatment Accelerates and Aggravates Autoimmune Pancreatitis in the MRL/Mp-Mouse

  2009cites this paper
• Crucial role of fibrogenesis in pancreatic diseases.

  2008cites this paper
• Inhibitory effects of interferon-gamma on activation of rat pancreatic stellate cells are mediated by STAT1 and involve down-regulation of CTGF expression.

  2007cites this paper
• Antifibrogenic effects of histone deacetylase inhibitors on pancreatic stellate cells.

  2007cites this paper
• Pancreatic stellate cells: New target in the treatment of chronic pancreatitis

  2007cites this paper
• Interferon-g Stimulated STAT1 Signalling: from Experimental Data to a Predictive Mathematical Model

  year unknowncites this paper