Preparation and antitumor activity of 4'-thio analogs of 2,2'-anhydro-1-beta-D-arabinofuranosylcytosine.

No abstract is available for this paper.

• Publication year

  1974

• Venue

  Journal of Medicinal Chemistry

• Publication date

  1974-05-01

• Fields of study

  Medicine, Chemistry

• Identifiers
  DOI 10.1021/JM00251A015PMID 4830257
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Studies on the mode of action of 2,2'-anhydro-1- -D-arabinofuranosylcytosine.

  1973cited by this paper
• Antitumor activity of cyclocytidine in a variety of tumors.

  1972cited by this paper
• Studies of the L1210 antileukemic activity of O-2,2'-cyclocytidine, monoacetate (anhydro-ara-C; NSC-129220)--comparison with cytosine arabinoside (NSC-63878) with respect to treatment schedule dependency.

  1972cited by this paper
• Studies on the Vilsmeier-Haack reaction. IV. Convenient synthesis of 2,2'-anhydro-1- -D-arabinofuranosylcytosine (2,2'-cyclocytidine) and its derivatives.

  1972cited by this paper
• Nucleic acids. 12. Synthesis of the L enantiomer of 1- -arabinofuranosylcytosine and of O 2 ,O 2' -anhydro-1- -D-arabinofuranosylcytosine.

  1971cited by this paper
• 4-thio-D-arabinofuranosylpyrimidine nucleosides.

  1971cited by this paper
• A general synthesis of pyrimidine nucleosides.

  1970cited by this paper
• Studies of the enzymatic deamination of cytosine arabinoside. I. Enzyme distribution and species specificity.

  1967cited by this paper
• Synthesis of purine and pyrimidine nucleosides of thiopentoses.

  1966cited by this paper
• Studies on synthetic nucleosides V. Anomeric pyrimidine nucleosides of D-arabinose and D-lyxose.

  1965cited by this paper
• Megaloblastosis produced by a cytosine antagonist, 1-beta-D-arabinofuranosylcytosine.

  1963cited by this paper
• Amino acid metabolism in mammalian cell cultures.

  1959cited by this paper

• Why Are 5-Thioglycopyranosyl Donors More Axially Selective than their Glycopyranosyl Counterparts? A Low and Variable Temperature NMR Spectroscopy and Computational Study

  2025cites this paper
• The chemistry and biology of natural ribomimetics and related compounds

  2022cites this paper
• Recent progress in the synthesis of C-4′-spironucleosides and its future perspectives

  2020cites this paper
• Versatile thiosugars in medicinal chemistry

  2020cites this paper
• Synthesis, Reactivity, and Stereoselectivity of 4-Thiofuranosides

  2019cites this paper
• Synthesis of 4'-Thionucleosides as Antitumor and Antiviral Agents.

  2018cites this paper
• Development of a Glycosylation Reaction: A Key to Accessing Structurally Unique Nucleosides

  2017cites this paper
• Practical Synthesis of 4'-Thioribonucleosides from L-Arabinose via Novel Reductive Ring-Contraction Reaction and Pummerer-Type Thioglycosylation.

  2017cites this paper
• Metabolism, Biochemical Actions, and Chemical Synthesis of Anticancer Nucleosides, Nucleotides, and Base Analogs.

  2016cites this paper
• Thiarabine, 1-(4-Thio-β-D-arabinofuranosyl)cytosine. A Deoxycytidine Analog With Excellent Anticancer Activity.

  2015cites this paper
• Isolation and Characterization of a Murine P388 Leukemia Line Resistant to Thiarabine

  2012cites this paper
• Calix[n]arenes in Action: Useful Host-Guest Catalysis in Organic Chemistry

  2012cites this paper
• Preclinical Antitumor Activity of Thiarabine in Human Leukemia and Lymphoma Xenograft Models

  2012cites this paper
• Preclinical Combination Therapy of Thiarabine Plus Various Clinical Anticancer Agents

  2012cites this paper
• Isolation and Characterization of a Murine P388 Leukemia Line Resistant to Clofarabine

  2011cites this paper
• Lack of in vivo cross-resistance with 4′-thio-ara-C against drug-resistant murine P388 and L1210 leukemias

  2011cites this paper
• Some recent trends and progress in nucleoside synthesis.

  2010cites this paper
• Calix[n]arenes mediated phase-transfer catalytic synthesis of purine derivatives

  2009cites this paper
• A practical synthesis of 4'-thioribonucleosides

  2006cites this paper
• A Knowledge-Based Weighting Approach to Ligand-Based Virtual Screening

  2006cites this paper
• A phase I, first in man study of OSI-7836 in patients with advanced refractory solid tumors: IND.147, a study of the Investigational New Drug Program of the National Cancer Institute of Canada Clinical Trials Group

  2006cites this paper
• Stereoselective Synthesis and Conformational Analysis of Aromatic C‐Thionucleosides.

  2006cites this paper
• Stereospecific Synthesis of Chiral 2,3‐Dihydro‐1,4‐benzodithiine and Methyl‐2,3‐dihydro‐1,4‐benzodithiine Derivatives and their Toxic Effects on Trypanosoma brucei

  2005cites this paper
• Stereoselective synthesis of conformationally constrained 2'-deoxy-4'-thia beta-anomeric spirocyclic nucleosides featuring either hydroxyl configuration at C5'.

  2005cites this paper
• CHEMICAL AND ENZYMATIC SYNTHESIS OF 4′-THIO-β-D-ARABINOFURANOSYLCYTOSINE MONOPHOSPHATE AND TRIPHOSPHATE

  2005cites this paper
• Synthesis, structure-activity relationships, and mechanism of drug resistance of D- and L-beta-3'-fluoro-2',3'-unsaturated-4'-thionucleosides as anti-HIV agents.

  2004cites this paper
• Synthesis and biological evaluation of some novel 4'-thio-L-ribonucleosides with modified nucleobase moieties.

  2003cites this paper
• Preclinical antitumor activity of 4′-thio-β-d-arabinofuranosylcytosine (4′-thio-ara-C)

  2003cites this paper
• A novel method for the synthesis of 4'-thiopyrimidine nucleosides using hypervalent iodine compounds.

  2003cites this paper
• Synthesis Of Nucleosides

  2002cites this paper
• Stereoselective synthesis and antiviral activity of D-2',3'-didehydro-2',3'-dideoxy-2'-fluoro-4'-thionucleosides.

  2002cites this paper
• Synthesis of novel L-2',3'-dideoxy-2'-trifluoromethyl-4'- thiocytidines from alpha-trifluoromethyl-alpha,beta-unsaturated ester.

  2002cites this paper
• Synthesis and biological evaluation of novel D-2'-azido-2',3'-dideoxyarabinofuranosyl-4'-thiopyrimidines and purines.

  2002cites this paper
• Prediction of Biological Activity for High-Throughput Screening Using Binary Kernel Discrimination

  2001cites this paper
• Sugar derivatives having sulfur in the ring.

  2001cites this paper
• A highly efficient synthesis of L-β-2′-deoxy-4′-thio-1′-purine nucleosides as potential antiviral agents

  2000cites this paper
• Synthesis of 4′-Thio-β-D-arabinofuranosylcytosine (4′-Thio-ara-C) and Comparison of Its Anticancer Activity with That of Ara-C

  2000cites this paper
• Database Searching for Compounds with Similar Biological Activity Using Short Binary Bit String Representations of Molecules

  1999cites this paper
• Analysis of a Large Structure/Biological Activity Data Set Using Recursive Partitioning

  1999cites this paper
• Synthetic studies on 2'-substituted-4'-thiocytidine derivatives as antineoplastic agents.

  1999cites this paper
• Compose de l-4'-arabinofuranonucleoside et composition medicinale le contenant

  1999cites this paper
• Herstellung von thioarabinofuranosyl-verbindungen und deren verwendung

  1999cites this paper
• Synthesis and biological activity of certain 4'-thio-D-arabinofuranosylpurine nucleosides.

  1998cites this paper
• Chemical Similarity Searching

  1998cites this paper
• Synthesis of L-enantiomers of 4'-thioarabinofuranosyl pyrimidine nucleosides.

  1998cites this paper
• Identification of Biological Activity Profiles Using Substructural Analysis and Genetic Algorithms

  1998cites this paper
• A Novel Synthesis of 2'-Modified 2'-Deoxy-4'-thiocytidines from D-Glucose(1).

  1997cites this paper
• A facile, alternative synthesis of 4'-thioarabinonucleosides and their biological activities.

  1997cites this paper
• Synthesis and anti-herpes virus activity of 2'-deoxy-4'-thiopyrimidine nucleosides.

  1996cites this paper
• Synthesis and antiviral activity of 2'-deoxy-4'-thio purine nucleosides.

  1996cites this paper
• Metabolism and metabolic actions of 4'-thiothymidine in L1210 cells.

  1995cites this paper
• Identification of structural similarity of organic molecules

  1995cites this paper
• Syntheses and antitumor activities of D- and L-2'-deoxy-4'-thio pyrimidine nucleosides

  1994cites this paper
• A new synthesis of some 4'-thio-D-ribonucleosides and preliminary enzymatic evaluation

  1994cites this paper
• Asymmetric synthesis of D- and L-2-deoxy-4-thioriboscs

  1994cites this paper
• A Facile Synthesis of 4′-Thio-2′-deoxypyrimidine Nucleosides and Preliminary Studies on Their Properties

  1993cites this paper
• Sulfur- and seleno-sugar modified nucleosides. Synthesis, chemical transformations and biological properties.

  1993cites this paper
• Efficient Synthesis of 4-Thio-D-ribofuranose and Some 4′-Thioribonucleosides

  1992cites this paper
• Synthesis and anti-HIV activity of 4'-thio-2',3'-dideoxynucleosides.

  1992cites this paper
• 2'3'-didesoxy-4'-thioribonucleosides utilises comme agents antiviraux et anticancereux

  1991cites this paper
• Synthesis and biological activity of 2'-deoxy-4'-thio pyrimidine nucleosides.

  1991cites this paper
• Albomycine, II. Absolute Konfiguration der Desferriform der Albomycine

  1984cites this paper
• Konstitution der Desferriform der Albomycine δ1, δ2 und 冇

  1982cites this paper
• Constitution of the Deferriform of the Albomycins δ1, δ2 and ε

  1982cites this paper
• Nucleoside Syntheses, XXIII1) On the Mechanism of Nucleoside Synthesis

  1981cites this paper
• Chemical Transformations of the Sugar Moiety of Nucleosides

  1979cites this paper
• Methods of Nucleoside Synthesis

  1979cites this paper
• CARBOHYDRATES CONTAINING SULFUR

  1979cites this paper
• ON THE MECHANISM OF NUCLEOSIDE SYNTHESIS

  1978cites this paper
• The synthesis of anomeric 3--acetyl-5--benzoyl-2-azido-2-deoxy--arabinofuranosyl chlorides. Versatile sugar intermediates for the synthesis of 2′-azido-2′-deoxy- and 2′-amino-2′-deoxy-β--arabinofuranosyl nucleosides.

  1978cites this paper
• Nucleoside und Nucleotide. Teil 10. Synthese von Thymidylyl‐(3′‐5′) ‐thymidylyl‐(3′‐5′)‐1‐(2′‐desoxy‐β‐D‐ribofuranosyl)‐2(1 H)‐pyridon

  1977cites this paper
• 5-thio-L-rhamnose.

  1977cites this paper
• Reactions of 2-acyloxyisobutyryl halides with nucleosides. 6. Synthesis and biological evaluation of some 3'-acyl derivatives of 2,2'-anhydro-1-(beta-D-arabinofuranosyl)cytosine hydrochloride.

  1976cites this paper
• Synthesis of 1-(4-thio-beta-D-ribofuranosyl)-1,2,4-triazole-3-carboxamide.

  1976cites this paper
• Chapter 14. Antineoplastic Agents

  1975cites this paper
• PREPARATION AND ANTITUMOR ACTIVITY OF 4′-THIO ANALOGS OF 2,2′-ANHYDRO-1-BETA-D-ARABINOFURANOSYLCYTOSINE

  1974cites this paper