Dilemma of Glial in Alzheimer’s: A Review of the Role of Glial Cells in Alzheimer’s Disease

Alzheimer’s disease (AD) is a progressive neurodegenerative brain disease worldwide. Though related studies are persistently conducted, the disease pathogenicity is yet to be fully deciphered. Most previous trails ended in failure and an effective treatment is an acute requirement. Current investigations attributed the cause of AD to neuronal cells. Nevertheless, non-neuron (i.e., glial cells) make up a considerable population of whole brain cells in the central nervous system and are highly associative with AD onset and progression. This review summarises some current findings of Alzheimer’s in the context of glial, highlighting the multiple functions of microglial cells and astrocytes in AD brains. The discussion was followed by crosstalk of Alzheimer’s, blood brain barrier, and glial cells, which broaden our understanding of the complexity and heterogenous dynamic of the disease. Extended studies are needed to further characterise the role of glial cells in neurodegenerative disorders, aiming to develop better therapeutic strategies in the coming years.

• Publication year

  2023

• Venue

  Highlights in Science Engineering and Technology

• Publication date

  2023-03-21

• Fields of study

  Not labeled

• Identifiers
  DOI 10.54097/hset.v36i.5645
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar

• No claims are published for this paper.

• No concepts are published for this paper.

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