Unusual Progressive Hepatic Echogenicity of the Pediatric Liver Following Intravenous Sonographic Contrast Administration

Contrast-enhanced ultrasound is a valuable tool to evaluate liver lesions in a pediatric patient cohort. Unusual progressive hepatic echogenicity (UPHE) is a self-limiting phenomenon noted in a cohort of children after administration of ultrasonographic contrast agents (UCAs). UPHE appears initially as heterogeneous branching similar to portal venous gas, culminating in a diffuse globular appearance. The etiology of UPHE is unclear and may be from underlying hepatic microvascular disease or altered gut permeability. This case series describes pediatric patients with UPHE following UCA bolus and discusses its potential mechanisms in children.

• Publication year

  2023

• Venue

  Journal of Diagnostic Medical Sonography

• Publication date

  2023-03-28

• Fields of study

  Not labeled

• Identifiers
  DOI 10.1177/87564793231158118
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar

• No claims are published for this paper.

• No concepts are published for this paper.

• Dietary Intake Mediates Ethnic Differences in Gut Microbial Composition

  2022cited by this paper
• Ethnicity influences the gut microbiota of individuals sharing a geographical location: a cross-sectional study from a middle-income country

  2021cited by this paper
• Persistent Heterogeneous Liver Enhancement after US Contrast Material Injection.

  2019influential reference
• Gut microbiota diversity across ethnicities in the United States

  2018cited by this paper
• Clinical diagnosis of veno-occlusive disease using contrast enhanced ultrasound

  2018cited by this paper
• Geography, Ethnicity or Subsistence-Specific Variations in Human Microbiome Composition and Diversity

  2017cited by this paper
• Age-related changes in gut microbiota composition from newborn to centenarian: a cross-sectional study

  2016cited by this paper
• Heterogeneous delayed enhancement of the liver after administration of ultrasound contrast agents: are we sure that it is a harmless phenomenon?

  2013cited by this paper
• Prolonged Heterogeneous Liver Enhancement on Contrast-Enhanced Ultrasound

  2013cited by this paper
• Guidelines and good clinical practice recommendations for Contrast Enhanced Ultrasound (CEUS) in the liver - update 2012: A WFUMB-EFSUMB initiative in cooperation with representatives of AFSUMB, AIUM, ASUM, FLAUS and ICUS.

  2013cited by this paper
• Heterogeneous staining in the liver parenchyma after the injection of perflubutane microbubble contrast agent.

  2012cited by this paper
• Acoustic Radiation Force Impulse Elastography and Contrast‐Enhanced Sonography of Sinusoidal Obstructive Syndrome (Veno‐occlusive Disease)

  2011cited by this paper
• Sinusoidal obstruction syndrome.

  2010cited by this paper
• Heterogeneous delayed enhancement of hepatic parenchyma after intravenous infusion of sonographic contrast agent: a new hypothesis

  2007cited by this paper
• Phagocytosis of ultrasound contrast agent microbubbles by Kupffer cells.

  2007cited by this paper
• Necrotizing enterocolitis: review of state-of-the-art imaging findings with pathologic correlation.

  2007cited by this paper
• Ultrastructural biologic effects of sonography with pulse inversion and microbubble contrast in rabbit liver

  2005cited by this paper
• Etiology of cecal and hepatic lesions in mice after administration of gas-carrier contrast agents used in ultrasound imaging.

  2003cited by this paper
• Heterogeneous delayed enhancement of the liver after ultrasound contrast agent injection--a normal variant.

  2002cited by this paper
• Mechanism of parenchymal enhancement of the liver with a microbubble-based US contrast medium: an intravital microscopy study in rats.

  2002cited by this paper

• No citing papers are available for this paper.