Naringin Treatment Improves Functional Recovery by Increasing BDNF and VEGF Expression, Inhibiting Neuronal Apoptosis After Spinal Cord Injury

No abstract is available for this paper.

• Publication year

  2012

• Venue

  Neurochemical Research

• Publication date

  2012-03-28

• Fields of study

  Medicine

• Identifiers
  DOI 10.1007/s11064-012-0756-7PMID 22453521
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Simvastatin treatment improves functional recovery after experimental spinal cord injury by upregulating the expression of BDNF and GDNF.

  2011cited by this paper
• Neuroprotective effects of Abacopterin E from Abacopteris penangiana against oxidative stress-induced neurotoxicity.

  2011cited by this paper
• Neuroprotective effect of naringin, a dietary flavonoid against 3-nitropropionic acid-induced neuronal apoptosis.

  2011cited by this paper
• Secondary injury mechanisms in traumatic spinal cord injury: a nugget of this multiply cascade.

  2011cited by this paper
• Naringin protects against kainic acid-induced status epilepticus in rats: evidence for an antioxidant, anti-inflammatory and neuroprotective intervention.

  2011cited by this paper
• Targeted Retrograde Gene Delivery of Brain-Derived Neurotrophic Factor Suppresses Apoptosis of Neurons and Oligodendroglia After Spinal Cord Injury in Rats

  2010cited by this paper
• Antioxidant properties, radical scavenging activity and biomolecule protection capacity of flavonoid naringenin and its glycoside naringin: a comparative study.

  2010cited by this paper
• Naringin alleviates cognitive impairment, mitochondrial dysfunction and oxidative stress induced by D-galactose in mice.

  2010cited by this paper
• Protective effects of the citrus flavanones to PC12 cells against cytotoxicity induced by hydrogen peroxide.

  2010cited by this paper
• Anti-inflammatory and analgesic properties of Drynaria quercifolia (L.) J. Smith.

  2010cited by this paper
• Antioxidant Activity and Protective Effects of Tripterygium regelii Extract on Hydrogen Peroxide-Induced Injury in Human Dopaminergic Cells, SH-SY5Y

  2010cited by this paper
• Protective effect of naringin against ischemic reperfusion cerebral injury: possible neurobehavioral, biochemical and cellular alterations in rat brain.

  2009cited by this paper
• Methylprednisolone fails to improve functional and histological outcome following spinal cord injury in rats.

  2009cited by this paper
• Inhibition of Cell Growth and VEGF Expression in Ovarian Cancer Cells by Flavonoids

  2008cited by this paper
• Flavonoids and vitamin E reduce the release of the angiogenic peptide vascular endothelial growth factor from human tumor cells.

  2006cited by this paper
• From angiogenesis to neuropathology

  2005cited by this paper
• BDNF-expressing marrow stromal cells support extensive axonal growth at sites of spinal cord injury.

  2005cited by this paper
• Neuroprotective properties of the natural phenolic antioxidants curcumin and naringenin but not quercetin and fisetin in a 6-OHDA model of Parkinson's disease

  2005cited by this paper
• Inflammation and apoptosis: linked therapeutic targets in spinal cord injury.

  2004cited by this paper
• Vascular endothelial growth factor improves functional outcome and decreases secondary degeneration in experimental spinal cord contusion injury.

  2003cited by this paper
• Effects of naringin on hydrogen peroxide-induced cytotoxicity and apoptosis in P388 cells.

  2003cited by this paper
• The Bcl-2 protein family: sensors and checkpoints for life-or-death decisions.

  2003cited by this paper
• Calpain in the pathophysiology of spinal cord injury: neuroprotection with calpain inhibitors.

  2003cited by this paper
• Miracles and molecules—progress in spinal cord repair

  2002cited by this paper
• Treatment of spinal cord impact injury in the rat with transforming growth factor-beta.

  2002cited by this paper
• The biochemistry and medical significance of the flavonoids.

  2002cited by this paper
• Naringin Has an Antiatherogenic Effect With the Inhibition of Intercellular Adhesion Molecule-1 in Hypercholesterolemic Rabbits

  2001cited by this paper
• Neurotrophic Factors and Receptors in the Immature and Adult Spinal Cord after Mechanical Injury or Kainic Acid

  2001cited by this paper
• Caspase-dependent apoptotic pathways in CNS injury

  2001cited by this paper
• Increased Calpain Expression Is Associated with Apoptosis in Rat Spinal Cord Injury: Calpain Inhibitor Provides Neuroprotection

  2000cited by this paper
• Oxidative damage to mitochondria in normal and cancer tissues, and its modulation.

  2000cited by this paper
• Brain-derived neurotrophic factor in astrocytes, oligodendrocytes, and microglia/macrophages after spinal cord injury.

  2000cited by this paper
• Activation of the caspase-3 apoptotic cascade in traumatic spinal cord injury

  1999cited by this paper
• Elevated oxidative stress in models of normal brain aging and Alzheimer's disease.

  1999cited by this paper
• Increase of interleukin-1β mRNA and protein in the spinal cord following experimental traumatic injury in the rat

  1997cited by this paper
• Consumption of quercetin and kaempferol in free-living subjects eating a variety of diets.

  1997cited by this paper
• Apoptosis and delayed degeneration after spinal cord injury in rats and monkeys

  1997cited by this paper
• Molecular Ordering of the Cell Death Pathway

  1996cited by this paper
• A Sensitive and Reliable Locomotor Rating Scale for Open Field Testing in Rats

  1995cited by this paper
• The effect of direct current field polarity on recovery after acute experimental spinal cord injury.

  1992cited by this paper
• Therapeutic Model for Experimental Spinal Cord Injury in the Rat: I. Mortality and Motor Deficit

  1987cited by this paper
• Genetic toxicology of dietary flavonoids.

  1986cited by this paper
• Genetic toxicology of dietary flavonoids.

  1986cited by this paper

• Naringenin alleviates spinal cord injury by ameliorating macrophage/microglia autophagy via progranulin stabilisation.

  2026cites this paper
• Therapeutic potential of flavonoids in neuroprotection: brain and spinal cord injury focus

  2025cites this paper
• The effects of combined low-intensity exercise with naringenin on regenerating protein family in vivo and in vitro after sciatic nerve injury

  2025cites this paper
• Therapeutic Potential of Flavonoids in Parkinson's Disease.

  2025cites this paper
• Latest Experimental Data on the Role of Vegf in the Treatment of Spinal Cord Injury

  2025cites this paper
• Cellular stress response and neuroprotection of flavonoids in neurodegenerative diseases: Clinical insights into targeted therapy and molecular signaling pathways.

  2024cites this paper
• Implication of Wnt/GSK-3β/β-Catenin Signaling in the Pathogenesis of Mood Disturbances Associated with Hyperthyroidism in Rats: Potential Therapeutic Effect of Naringin.

  2023cites this paper
• A clinical study and future prospects for bioactive compounds and semi-synthetic molecules in the therapies for Huntington's disease

  2023cites this paper
• Naringin modulates microglial polarization through the PPAR-γ/NF-κB signaling pathway to promote functional recovery following spinal cord injury.

  2023cites this paper
• Phytopharmaceuticals in Neurodegenerative Disorders

  2023cites this paper
• The protective roles of citrus flavonoids, naringenin, and naringin on endothelial cell dysfunction in diseases

  2023cites this paper
• Pre-Clinical Assessment of Roflumilast Therapy in a Thoracic Model of Spinal Cord Injury

  2023cites this paper
• Neurotrophic basis to the pathogenesis of depression and phytotherapy

  2023cites this paper
• Naringin Prevents Cognitive Dysfunction in Aging Rats by Inhibiting Toll-Like Receptor 4 (TLR4)/NF-κB Pathway and Endoplasmic Reticulum Stress

  2023cites this paper
• Increase in Effect of Citrus natsudaidai on Brain-Derived Neurotrophic Factor.

  2023cites this paper
• Polyphenols Targeting Oxidative Stress in Spinal Cord Injury: Current Status and Future Vision

  2022cites this paper
• Bioactive compounds for neuropathic pain: an update on preclinical studies and future perspectives.

  2022cites this paper
• Naringin Mediates Adult Hippocampal Neurogenesis for Antidepression via Activating CREB Signaling

  2022cites this paper
• TAT&RGD Peptide-Modified Naringin-Loaded Lipid Nanoparticles Promote the Osteogenic Differentiation of Human Dental Pulp Stem Cells

  2022cites this paper
• Effects of combination treatment with transcranial magnetic stimulation and bone marrow mesenchymal stem cell transplantation or Raf inhibition on spinal cord injury in rats

  2021cites this paper
• HnRNP G Reduces Neuron Death in Amyotrophic Lateral Sclerosis by Preventing Abnormal TDP-43 Accumulation

  2021cites this paper
• Natural Products for Neurodegeneration: Regulating Neurotrophic Signals

  2021cites this paper
• Curcumin exhibits therapeutic effect against spinal cord injury via inhibition of neuronal inflammation and apoptosis

  2021cites this paper
• Isolation, Characterization and the Biological Activity of Some Natural Components of Marine Sea Cucumber and Orange Peel

  2020cites this paper
• Optimized preparation process for naringenin and evaluation of its antioxidant and α‐glucosidase inhibitory activities

  2020cites this paper
• Peripheral nerve regeneration in rats by chitosan/alginate hydrogel composited with Berberine and Naringin nanoparticles: in vitro and in vivo study

  2020cites this paper
• Implications of phytochemicals as disease-modifying agents against Huntington's disease (HD): Bioactivity, animal models and transgenics, synergism and structure–activity studies

  2020cites this paper
• Targeting apoptosis and autophagy following spinal cord injury: Therapeutic approaches to polyphenols and candidate phytochemicals.

  2020cites this paper
• Ludartin exhibits therapeutic effect on spinal cord injury through inhibition of apoptosis and inflammation

  2019cites this paper
• Naringin: Biosynthesis and Pharmaceutical Applications

  2019cites this paper
• Improvement of motor function induced by skeletal muscle contraction in spinal cord-injured rats.

  2019cites this paper
• Sciatic nerve regeneration by using collagen type I hydrogel containing naringin

  2019cites this paper
• Epidural oscillating field stimulation as an effective therapeutic approach in combination therapy for spinal cord injury.

  2019cites this paper
• Nutraceuticals to promote neuronal plasticity in response to corticosterone-induced stress in human neuroblastoma cells

  2019cites this paper
• Therapeutic potential of naringin in neurological disorders.

  2019cites this paper
• Polypyrrole/polylactic acid nanofibrous scaffold cotransplanted with bone marrow stromal cells promotes the functional recovery of spinal cord injury in rats

  2019cites this paper
• The citrus flavonoids hesperidin and naringin alleviate alcohol-induced behavioural alterations and developmental defects in zebrafish larvae.

  2019cites this paper
• Naringin enhances endothelial progenitor cell (EPC) proliferation and tube formation capacity through the CXCL12/CXCR4/PI3K/Akt signaling pathway.

  2018cites this paper
• Protective effect of vitexin reduces sevoflurane-induced neuronal apoptosis through HIF-1α, VEGF and p38 MAPK signaling pathway in vitro and in newborn rats.

  2018cites this paper
• Early electrical field stimulation prevents the loss of spinal cord anterior horn motoneurons and muscle atrophy following spinal cord injury

  2018cites this paper
• Protective effects of Naringin in a rat model of spinal cord ischemia–reperfusion injury

  2017cites this paper
• Bergamot Polyphenolic Fraction Supplementation Improves Cognitive Functioning in Schizophrenia: Data From an 8-Week, Open-Label Pilot Study

  2017cites this paper
• Naringin inhibits vascular endothelial cell apoptosis via endoplasmic reticulum stress- and mitochondrial-mediated pathways and promotes intraosseous angiogenesis in ovariectomized rats

  2017cites this paper
• Neurotrophic function of phytochemicals for neuroprotection in aging and neurodegenerative disorders: modulation of intracellular signaling and gene expression

  2017cites this paper
• Biotransformation of Flavonoid Conjugates with Fatty Acids and Evaluations of Their Functionalities

  2017cites this paper
• Therapeutic effect of apocynin through antioxidant activity and suppression of apoptosis and inflammation after spinal cord injury

  2017cites this paper
• Naringin promotes fracture healing through stimulation of angiogenesis by regulating the VEGF/VEGFR-2 signaling pathway in osteoporotic rats.

  2017cites this paper
• Naringin as a beneficial natural product against degeneration of the nigrostriatal dopaminergic projection in the adult brain

  2017influential citation
• Naringin protects viscera from ischemia/reperfusion injury by regulating the nitric oxide level in a rat model

  2017cites this paper
• The mechanism of Naringin-enhanced remyelination after spinal cord injury

  2017cites this paper
• The beneficial role of Naringin- a citrus bioflavonoid, against oxidative stress-induced neurobehavioral disorders and cognitive dysfunction in rodents: A systematic review and meta-analysis.

  2017cites this paper
• Role of apoptosis genes in aggression revealed using combined analysis of ANDSystem gene networks, expression and genomic data in grey rats with aggressive behavior

  2017influential citation
• Natural Products against Huntington's Disease (HD): Implications of Neurotoxic Animal Models and Transgenics in Preclinical Studies

  2017cites this paper
• Adsorption of Three Flavonoids from Aqueous Solutions onto Mesoporous Carbon

  2017cites this paper
• Modulating adult neurogenesis through dietary interventions

  2016cites this paper
• Mechanism of JAK-STAT signaling pathway inhibitor in post-spinal cord injury

  2016cites this paper
• Aloe Vera’s Effect on Acetyl Cholinesterase(AChE) and Ultra Structure of Motoneurons in Synaptic Zone After Spinal Cord Injury in Rats

  2016cites this paper
• Low-energy extracorporeal shock wave therapy for promotion of vascular endothelial growth factor expression and angiogenesis and improvement of locomotor and sensory functions after spinal cord injury.

  2016cites this paper
• Neurodegenerative Diseases: Might Citrus Flavonoids Play a Protective Role?

  2016cites this paper
• Alleviation of spinal cord injury by Ginkgolide B via the inhibition of STAT1 expression.

  2016cites this paper
• Agent for reconstructing/activating neural network

  2016cites this paper
• Solubility of naringin in ethanol and water mixtures from 283.15 to 318.15K

  2015cites this paper
• Oscillating field stimulation promotes recovery after spinal cord injury in rats: Assessment using behavioral, electrophysiological and histological evaluations

  2015cites this paper
• Naringin ameliorates cognitive deficits via oxidative stress, proinflammatory factors and the PPARγ signaling pathway in a type 2 diabetic rat model.

  2015cites this paper
• Early applied electric field stimulation attenuates secondary apoptotic responses and exerts neuroprotective effects in acute spinal cord injury of rats.

  2015cites this paper
• Naringin protects the nigrostriatal dopaminergic projection through induction of GDNF in a neurotoxin model of Parkinson's disease.

  2014cites this paper
• Hyaluronan Tetrasaccharide Exerts Neuroprotective Effect and Promotes Functional Recovery After Acute Spinal Cord Injury in Rats

  2014cites this paper
• Flavonoids inhibit iNOS production via mitogen activated proteins in lipoteichoic acid stimulated cardiomyoblasts.

  2014cites this paper
• Vascular endothelial growth factor-loaded injectable hydrogel enhances plasticity in the injured spinal cord.

  2014cites this paper
• Melatonin and tadalafil treatment improves erectile dysfunction after spinal cord injury in rats

  2014cites this paper
• Naringin: A Protector of the Nigrostriatal Dopaminergic Projection

  2014cites this paper
• THE EFFECTS OF DEPRENYLONSYNAPTIC ZONE AFTER SPINAL CORD INJURY IN RATS

  2014cites this paper
• Continual Naringin Treatment Benefits the Recovery of Traumatic Brain Injury in Rats Through Reducing Oxidative and Inflammatory Alterations

  2014cites this paper
• Preclinical Evidence for the Pharmacological Actions of Naringin: A Review

  2014cites this paper
• Oscillating field stimulation promotes spinal cord remyelination by inducing differentiation of oligodendrocyte precursor cells after spinal cord injury

  2014cites this paper
• Effects of naringin, a flavanone glycoside in grapefruits and citrus fruits, on the nigrostriatal dopaminergic projection in the adult brain

  2014influential citation
• iNOS: inducible nitric oxide synthase IRS-1: insulin receptor substrate-1 JNK: c-Jun N-terminal kinase Kir: inward rectifying potassium channel LPS: lipopolysaccharides MAPK: p38 mitogen-activated protein kinase MCP-1: monocyte chemotactic protein-1 MDR: multidrug-resistance protein MIP-1α: macropha

  2014cites this paper
• Targeted delivery of biodegradable nanoparticles with ultrasound-targeted microbubble destruction-mediated hVEGF-siRNA transfection in human PC-3 cells in vitro.

  2013cites this paper
• VEGF-loaded injectable hydrogel enhances plasticity in the injured spinal cord

  2013cites this paper
• Protective Effect of Ginkgolide B Against Acute Spinal Cord Injury in Rats and Its Correlation with the JAK/STAT Signaling Pathway

  2013cites this paper
• Intrathecal Epigallocatechin Gallate Treatment Improves Functional Recovery After Spinal Cord Injury by Upregulating the Expression of BDNF and GDNF

  2013cites this paper
• Expression of RBMX After Spinal Cord Injury in Rats

  2013cites this paper
• Beneficial effects of quercetin on rat urinary bladder after spinal cord injury.

  2013cites this paper
• Temporal expression profile of CXC chemokines in serum of patients with spinal cord injury.

  2013cites this paper
• Montelukast inhibits caspase-3 activity and ameliorates oxidative damage in the spinal cord and urinary bladder of rats with spinal cord injury.

  2012cites this paper
• Endogenous Proliferation after Spinal Cord Injury in Animal Models

  2012cites this paper
• Inhibition of Ca2+ Entry and Suicidal Erythrocyte Death by Naringin

  2012cites this paper
• cognitive deficits via oxidative stress, proinflammatory factors and the PPAR γ signaling pathway in a type 2 diabetic rat model

  year unknowncites this paper