Mechanosensitive mTORC1 signaling maintains lymphatic valves

Saygili Demir, Sabine et al. identify proliferating valve sinus endothelial cells as a main source for repair of postnatal lymphatic vessels. The process is driven by mechanosensitive mTORC1 activation, which controls both proliferation and protein synthesis. These findings provide a mechanistic explanation for increased incidence of lymphedema in rapamycin-treated patients.

• Publication year

  2023

• Venue

  Journal of Cell Biology

• Publication date

  2023-04-10

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1083/jcb.202207049PMID 37036444PMCID 10097975
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

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