Inhibiting inducible nitric oxide synthase with rutin reduces renal ischemia/reperfusion injury.

No abstract is available for this paper.

• Publication year

  2013

• Venue

  Canadian journal of surgery. Journal canadien de chirurgie

• Publication date

  2013-02-01

• Fields of study

  Medicine

• Identifiers
  DOI 10.1503/cjs.004811PMID 23187035PMCID PMC3569478
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Protective effect of rutin on the ischemia/reperfusion induced damage in rat kidney.

  2010influential reference
• Attenuation of renal ischemia–reperfusion injury by postconditioning involves adenosine receptor and protein kinase C activation

  2010cited by this paper
• The Protective Effects of Ascorbic Acid against Renal Ischemia-Reperfusion Injury in Male Rats

  2009cited by this paper
• α-tocopherol, ascorbic acid, and rutin inhibit synergistically the copper-promoted LDL oxidation and the cytotoxicity of oxidized LDL to cultured endothelial cells

  2007cited by this paper
• NO and NOS isoforms in the development of apoptosis in renal ischemia/reperfusion.

  2006cited by this paper
• Combined enzymatic and antioxidative treatment reduces ischemia-reperfusion injury in rabbit skeletal muscle.

  2006cited by this paper
• Inhibition of nitric oxide synthase reduces renal ischemia/reperfusion injury.

  2005cited by this paper
• Nitric oxide, oxidative stress, and progression of chronic renal failure.

  2004cited by this paper
• The effect of naringin, a bioflavonoid on ischemia-reperfusion induced renal injury in rats.

  2004cited by this paper
• Ischemia–reperfusion injury pathophysiology, part I

  2004cited by this paper
• NO bioavailability, endothelial dysfunction, and acute renal failure: new insights into pathophysiology.

  2004influential reference
• Synergistic inhibition of low-density lipoprotein oxidation by rutin, gamma-terpinene, and ascorbic acid.

  2004cited by this paper
• GW274150, a potent and highly selective inhibitor of iNOS, reduces experimental renal ischemia/reperfusion injury.

  2003cited by this paper
• Reperfusion injury is reduced in skeletal muscle by inhibition of inducible nitric oxide synthase.

  2003cited by this paper
• The effect of quercetin on renal ischemia and reperfusion injury in the rat

  2002cited by this paper
• Inducible nitric oxide synthase in renal transplantation.

  2002cited by this paper
• Inhibition of inducible nitric oxide synthase reduces renal ischemia/reperfusion injury.

  2002cited by this paper
• Role of flavonoids in oxidative stress.

  2001cited by this paper
• Immunodetection of 3-nitrotyrosine in the liver of zymosan-treated rats with a new monoclonal antibody: comparison to analysis by HPLC.

  2001cited by this paper
• Localization of protein inhibitor of neuronal nitric oxide synthase in rat kidney.

  2000cited by this paper
• Evidence for peroxynitrite formation in renal ischemia-reperfusion injury: studies with the inducible nitric oxide synthase inhibitor L-N(6)-(1-Iminoethyl)lysine.

  2000cited by this paper
• Biology of nitric oxide signaling

  2000cited by this paper
• Biphasic role for nitric oxide in experimental renal warm ischaemia–reperfusion injury

  1999cited by this paper
• Ischemia and reperfusion injury in transplantation.

  1999cited by this paper
• Structure-activity relationship and classification of flavonoids as inhibitors of xanthine oxidase and superoxide scavengers.

  1998cited by this paper
• Nitric oxide-mediated renal epithelial cell injury during hypoxia and reoxygenation.

  1998cited by this paper
• Effect of bioflavonoids quercetin and curcumin on ischemic renal injury: a new class of renoprotective agents.

  1998cited by this paper
• Nitric oxide metabolism following unilateral renal ischemia/reperfusion injury in rats

  1998cited by this paper
• Flavonoids: Dietary occurrence and biochemical activity

  1998cited by this paper
• Biology of ischemic and toxic renal tubular cell injury: role of nitric oxide and the inflammatory response

  1998cited by this paper
• Distribution of nitric oxide synthase and nitric oxide-receptive, cyclic GMP-producing structures in the rat brain.

  1998cited by this paper
• Nitric oxide generation is increased in experimental renal warm ischaemia–reperfusion injury

  1998cited by this paper
• Effect of plant flavonoids on immune and inflammatory cell function.

  1998cited by this paper
• N-acetyl cysteine ameliorates ischemic renal failure.

  1997cited by this paper
• Bioavailability of rutin and quercetin in rats

  1997cited by this paper
• Nitric oxide in renal health and disease.

  1997cited by this paper
• In vivo targeting of inducible NO synthase with oligodeoxynucleotides protects rat kidney against ischemia.

  1996cited by this paper
• Guide for the Care and Use of Laboratory Animals

  1996cited by this paper
• alpha-Tocopherol, ascorbic acid, and rutin inhibit synergistically the copper-promoted LDL oxidation and the cytotoxicity of oxidized LDL to cultured endothelial cells.

  1995cited by this paper
• Nitric oxide and oxygen radicals: a question of balance

  1995cited by this paper
• The characterization of antioxidants.

  1995cited by this paper
• The chemistry of peroxynitrite: a product from the reaction of nitric oxide with superoxide.

  1995cited by this paper
• Inflammation, immunoregulation, and inducible nitric oxide synthase

  1993cited by this paper
• Pathophysiology of experimental nonoliguric acute renal failure.

  1993cited by this paper
• The L-arginine: nitric oxide pathway.

  1993cited by this paper
• The flavonoids : new perspectives in biological activities and therapeutics

  1993cited by this paper
• The L-arginine-nitric oxide pathway.

  1993cited by this paper
• Additional antilipoperoxidant activities of alpha-tocopherol and ascorbic acid on membrane-like systems are potentiated by rutin.

  1991cited by this paper
• The cell biology of ischemic renal injury.

  1991cited by this paper
• Mediators of ischemic renal injury.

  1989cited by this paper
• Flavonoids are scavengers of superoxide anions.

  1988cited by this paper
• Oxygen-derived free radicals in postischemic tissue injury.

  1985cited by this paper
• Oxygen free radicals in ischemic acute renal failure in the rat.

  1984cited by this paper
• Experimental and surgical technique in the rat.

  1980cited by this paper
• Downloaded from http://hyper.ahajournals.org / by guest on February 23, 2013Nitric Oxide Synthase Activity and Isoforms in Rat Renal Vasculature

  year unknowncited by this paper

• Rosmarinic acid: a promising agent for male rats’ renal protection against ischemia/reperfusion injury

  2025cites this paper
• Investigating the nitric oxide pathway stimulated by rosuvastatin on the pathological effects of renal ischemia-reperfusion in rats.

  2025cites this paper
• Rutin and skeletal muscle ischemia-reperfusion injury: Effects of acute treatment.

  2025cites this paper
• Molecular mechanisms underlying methotrexate-induced intestinal injury and protective strategies

  2024cites this paper
• Rutin alleviates lupus nephritis by inhibiting T cell oxidative stress through PPARγ.

  2024cites this paper
• Quercetin’s Restorative Properties in Male Mice with 3-Nitropropionic Acid-induced Huntington-like Symptoms: Molecular Docking, Behavioral, and Biochemical Assessment

  2024cites this paper
• Cold Storage Followed by Transplantation Induces Interferon-Gamma and STAT-1 in Kidney Grafts

  2023cites this paper
• Neuroprotective effects of silymarin in 3-nitropropionic acid-induced neurotoxicity in male mice: improving behavioral deficits by attenuating oxidative stress and neuroinflammation

  2023cites this paper
• Flavonoids-mediated TLR4 inhibition as a promising therapy for renal diseases.

  2023cites this paper
• Targeting the innate repair receptor axis via erythropoietin or pyroglutamate helix B surface peptide attenuates hemolytic-uremic syndrome in mice

  2022cites this paper
• Renoprotective effect of vinpocetine against ischemia/reperfusion injury: Modulation of NADPH oxidase/Nrf2, IKKβ/NF‐κB p65, and cleaved caspase‐3 expressions

  2022cites this paper
• Metabolites Analysis of Anti-Myocardial Ischemia Active Components of Saussurea involucrata Based on Gut Microbiota—Drug Interaction

  2022cites this paper
• Promoting Plant-Based Therapies for Chronic Kidney Disease

  2022cites this paper
• The efficiency of oxerutin on apoptosis and kidney function in rats with renal ischemia reperfusion injury

  2022cites this paper
• Protective Effects and Mechanisms of Flavonoids in Renal Ischemia-Reperfusion Injury

  2022cites this paper
• Pioglitazone modulates immune activation and ameliorates inflammation induced by injured renal tubular epithelial cells via PPARγ/miRNA‑124/STAT3 signaling

  2022cites this paper
• Augmenter of liver regeneration reduces mitochondria-derived ROS and NLRP3 inflammasome activation through PINK1/Parkin-mediated mitophagy in ischemia-reperfusion-induced renal tubular injury

  2022cites this paper
• The protective effects of exogenous spermine on renal ischemia-reperfusion injury in rats

  2021cites this paper
• Entacapone scavenges peroxynitrite and protects against kidney and liver injuries induced by renal ischemia/reperfusion in rats

  2021cites this paper
• The Protective Effect of Rutin Against Methotrexate- Induced Nephrotoxicity in Rats

  2021cites this paper
• Effect of pheniramine maleate on rat skeletal muscle ischemia-reperfusion injury

  2021cites this paper
• Renoprotective Role of Hypoxia-Inducible Factors and the Mechanism

  2021cites this paper
• Pharmacological properties of rutin and its potential uses for Alzheimer’s disease

  2021cites this paper
• circ‐AKT3 aggravates renal ischaemia‐reperfusion injury via regulating miR‐144‐5p /Wnt/β‐catenin pathway and oxidative stress

  2020cites this paper
• Saussureae Involucratae Herba (Snow Lotus): Review of Chemical Compositions and Pharmacological Properties

  2020cites this paper
• Effect of hypercholesterolemia on hypertension-induced renal injury in rats: Insights in the possible mechanisms

  2020cites this paper
• Neuroprotection: Targeting Multiple Pathways by Naturally Occurring Phytochemicals

  2020cites this paper
• Herbal antioxidants and renal ischemic-reperfusion injury; an updated review

  2020cites this paper
• Plumula Nelumbinis: A Review of Traditional Uses, Phytochemistry, Pharmacology, Pharmacokinetics and Safety.

  2020cites this paper
• Targeting Inflammation and Oxidative Stress as a Therapy for Ischemic Kidney Injury

  2020cites this paper
• Воспаление и окислительный стресс как мишени для терапии ишемического повреждения почек

  2020cites this paper
• Oleanolic Acid Improves the Symptom of Renal Ischemia Reperfusion Injury via the PI3K/AKT Pathway

  2020cites this paper
• Potential Protective Role of Rutin and Alpha-lipoic Acid Against Cisplatin-induced Nephrotoxicity in Rats.

  2019cites this paper
• Mulberry leaf aqueous extract ameliorates blood glucose and enhances energy expenditure in obese C57BL/6J mice

  2019cites this paper
• Protective effects of Allium hirtifolium Boiss extract on cadmium-induced renal failure in rats

  2019cites this paper
• Casearia decandra leaves present anti-inflammatory efficacy in a skin inflammation model in mice.

  2019cites this paper
• Tissue-Resident Macrophages Promote Renal Cystic Disease.

  2019cites this paper
• The role of nitric oxide and inflammatory cytokines in delayed graft function of DCD renal transplants : the effect of induction immunosuppression

  2018influential citation
• Rutin attenuates cerebral ischemia-reperfusion injury in ovariectomized rats via estrogen-receptor-mediated BDNF-TrkB and NGF-TrkA signaling.

  2018cites this paper
• Rutin, a quercetin glycoside, alleviates acute endotoxemic kidney injury in C57BL/6 mice via suppression of inflammation and up‐regulation of antioxidants and SIRT1

  2018cites this paper
• H2S attenuates acute lung inflammation induced by administration of lipopolysaccharide in adult male rats.

  2018cites this paper
• Ameliorative effect of Rutin on sodium fluoride‐induced hypertension through modulation of Kim‐1/NF‐κB/Nrf2 signaling pathway in rats

  2018cites this paper
• Protective effect of the standardized leaf extract of Ginkgo biloba (EGb761) against hypertension-induced renal injury in rats

  2018cites this paper
• RUTIN: A PHARMACOLOGICAL REVIEW

  2018cites this paper
• ARTÍCULO ORIGINAL

  2018cites this paper
• Protective effect of the standardized extract of ginkgo biloba (EGb761) against hypertension with hypercholesterolemia-induced renal injury in rats: Insights in the underlying mechanisms.

  2017cites this paper
• Pharmacokinetics of Botanical Drugs and Plant Extracts.

  2017cites this paper
• The Effects of Baicalin on Myoglobinuric Acute Renal Failure in Rats

  2017cites this paper
• Effect of cardamonin on hepatic ischemia reperfusion induced in rats: Role of nitric oxide

  2017cites this paper
• The Underrated Carbonate Radical (CO3•–) – Detoxification and Reduced Formation by Melatonin

  2017cites this paper
• The flavonoid rutin improves kidney and heart structure and function in an adenine-induced rat model of chronic kidney disease

  2017cites this paper
• Cerebroprotective activity of Pentapetes phoenicea on global cerebral ischemia in rats

  2016cites this paper
• Rutin ameliorates kidney interstitial fibrosis in rats with obstructive nephropathy.

  2016cites this paper
• The Pharmacological Potential of Rutin

  2016cites this paper
• Rutin ameliorates renal fibrosis and proteinuria in 5/6-nephrectomized rats by anti-oxidation and inhibiting activation of TGFβ1-smad signaling.

  2015cites this paper
• The Benefit of the Reperfusion Procedure after Renal Ischaemia in Rabbits Being Initiated with Distilled Water

  2015cites this paper
• Effects of intraperitoneal hydrogen injection on nitric oxide synthase mRNA and malondialdehyde following limb ischemia-reperfusion in rabbits.

  2015cites this paper
• Rutin attenuates gentamicin-induced renal damage by reducing oxidative stress, inflammation, apoptosis, and autophagy in rats

  2015cites this paper
• Ameliorative potential of vitamin P and digoxin in ischemic-reperfusion induced renal injury using the Langendorff apparatus.

  2015cites this paper
• Nephroprotective Effects of Polydatin against Ischemia/Reperfusion Injury: A Role for the PI3K/Akt Signal Pathway

  2015cites this paper
• You-gui Pill ameliorates renal tubulointerstitial fibrosis via inhibition of TGF-β/Smad signaling pathway.

  2015cites this paper
• Organ-Protective Effects of Red Wine Extract, Resveratrol, in Oxidative Stress-Mediated Reperfusion Injury

  2015cites this paper
• Effect of Experimental Renal Ischemia Reperfusion Injury on Hypothalamic-Pituitary-Gonadal Axis in Male Rats : Role of Hypoxia Inducible Factor-1 α ( HIF-1 α )

  2015cites this paper
• Dioclea violacea lectin ameliorates oxidative stress and renal dysfunction in an experimental model of acute kidney injury.

  2015cites this paper
• Modulation of nitric oxide by flavonoids.

  2014cites this paper
• Rutin stimulates sarcoplasmic reticulum Ca2+-ATPase activity (SERCA1) and protects SERCA1 from peroxynitrite mediated injury

  2014cites this paper
• 1400W reduces ischemia reperfusion injury in an ex-vivo porcine model of the donation after circulatory death kidney donor.

  2014cites this paper
• Protection of Wistar‐Furth rats against postischaemic acute renal injury: Role for nitric oxide and thromboxane?

  2014cites this paper
• Role of Rutin on Nitric Oxide Synthesis in Human Umbilical Vein Endothelial Cells

  2014cites this paper
• Effect of Tephrosia purpurea (L.) Pers. Leaves on Gentamicin-Induced Nephrotoxicity in Rats

  2013cites this paper
• Protective effect of rutin against ultraviolet b-induced cyclooxygenase-2 expression in mouse epidermal cells

  2013cites this paper
• Protective effect of rutin on hexachlorobutadiene-induced nephrotoxicity

  2013cites this paper
• Oxidative stress and behavioral de�cits in 3-nitropropionic acid-induced neurotoxicity in male mice: Neuroprotective effects of silymarin

  year unknowncites this paper