Internalization of basic fibroblast growth factor at the mouse blood–brain barrier involves perlecan, a heparan sulfate proteoglycan

No abstract is available for this paper.

• Publication year

  2002

• Venue

  Journal of Neurochemistry

• Publication date

  2002-10-01

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1046/j.1471-4159.2002.01129.xPMID 12423248
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Blood-Brain Barrier Transport of 125I-Labeled Basic Fibroblast Growth Factor

  2004cited by this paper
• Thyroid hormone induces cerebellar astrocytes and C6 glioma cells to secrete mitogenic growth factors.

  2001cited by this paper
• Establishment and functional characterization of an in vitro model of the blood-brain barrier, comprising a co-culture of brain capillary endothelial cells and astrocytes.

  2001cited by this paper
• Conditionally immortalized cell lines as a new in vitro model for the study of barrier functions.

  2001cited by this paper
• Conditionally immortalized brain capillary endothelial cell lines established from a transgenic mouse harboring temperature-sensitive simian virus 40 large T-antigen gene

  2000cited by this paper
• Mechanisms of fibroblast growth factor 2 intracellular processing: a kinetic analysis of the role of heparan sulfate proteoglycans.

  2000cited by this paper
• Fibroblast growth factor-2.

  2000cited by this paper
• Fibroblast growth factor-2.

  2000cited by this paper
• Induction of blood-brain barrier properties in immortalized bovine brain endothelial cells by astrocytic factors.

  1999cited by this paper
• Heparan sulfate proteoglycans control intracellular processing of bFGF in vascular smooth muscle cells.

  1998cited by this paper
• Biological roles of fibroblast growth factor-2.

  1997cited by this paper
• Induction of various blood‐brain barrier properties in non‐neural endothelial cells by close apposition to co‐cultured astrocytes

  1997cited by this paper
• Metabolism of the intravenously administered recombinant human basic fibroblast growth factor, trafermin, in liver and kidney: degradation implicated in its selective localization to the fenestrated type microvasculatures.

  1997cited by this paper
• Human blood-brain barrier leptin receptor. Binding and endocytosis in isolated human brain microvessels.

  1997cited by this paper
• Expression of the fibroblast growth factor family and their receptor family genes during mouse brain development.

  1996cited by this paper
• Basic Fibroblast Growth Factor Binds Its Receptors, Is Internalized, and Stimulates DNA Synthesis in Balb/c3T3 Cells in the Absence of Heparan Sulfate*

  1996cited by this paper
• Proteoglycans of the extracellular environment: clues from the gene and protein side offer novel perspectives in molecular diversity and function

  1996cited by this paper
• Basic fibroblast growth factor (FGF-2) internalization through the heparan sulfate proteoglycans-mediated pathway: an ultrastructural approach.

  1995cited by this paper
• Transient global ischemia induces dynamic changes in the expression of bFGF and the FGF receptor.

  1994cited by this paper
• Perlecan, basal lamina proteoglycan, promotes basic fibroblast growth factor-receptor binding, mitogenesis, and angiogenesis.

  1994cited by this paper
• Basic Fibroblast Growth Factor Protects Cerebrocortical Neurons Against Excitatory Amino Acid Toxicity In Vitro

  1993cited by this paper
• Internalization of basic fibroblast growth factor (bFGF) in cultured endothelial cells: Role of the low affinity heparin‐like bFGF receptors

  1993cited by this paper
• Mice Expressing a Bovine Basic Fibroblast Growth Factor Transgene in the Brain Show Increased Resistance to Hypoxemic‐Ischemic Cerebral Damage

  1993cited by this paper
• Identification of the basic fibroblast growth factor binding sequence in fibroblast heparan sulfate.

  1992cited by this paper
• In‐vivo Blood‐brain Barrier Transport of a Novel Adrenocorticotropic Hormone Analogue, Ebiratide, Demonstrated by Brain Microdialysis and Capillary Depletion Methods

  1992cited by this paper
• Basic fibroblast growth factor is internalized through both receptor-mediated and heparan sulfate-mediated mechanisms.

  1992influential reference
• In Vivo Transport of a Dynorphin-like Analgesic Peptide, E-2078, Through the Blood–Brain Barrier: An Application of Brain Microdialysis

  1991cited by this paper
• Evaluation of cationized rat albumin as a potential blood-brain barrier drug transport vector.

  1990cited by this paper
• Transport of histone through the blood-brain barrier.

  1989cited by this paper
• BLOOD-BRAIN BARRIER TRANSPORT

  1988cited by this paper
• Receptor‐mediated transcytosis of transferrin across the blood‐brain barrier

  1987cited by this paper
• Blood-brain barrier transcytosis of insulin in developing rabbits.

  1987cited by this paper
• Astrocytes induce blood–brain barrier properties in endothelial cells

  1987cited by this paper
• Basic fibroblast growth factor supports the survival of cerebral cortical neurons in primary culture.

  1986cited by this paper
• The enzymatic degradation of heparin and heparitin sulfate. 3. Purification of a heparitinase and a heparinase from flavobacteria.

  1970cited by this paper

• Transport of CCL2 across an induced pluripotent stem cell-derived in vitro model of the human blood-brain barrier is heparan sulfate-dependent

  2025cites this paper
• The Ambiguous Role of Growth Factors in Autism: What Do We Really Know?

  2025cites this paper
• Brain vascular basement membrane: comparison of human and mouse brain at the transcriptomic and proteomic levels.

  2025cites this paper
• Controlled growth factor delivery via a degradable poly(lactic acid) hydrogel microcarrier synthesized using degassed micromolding lithography.

  2022cites this paper
• Perlecan Improves Blood Spinal Cord Barrier Repair Through the Integrin β1/ROCK/MLC Pathway After Spinal Cord Injury

  2022cites this paper
• Transport of the Proinflammatory Chemokines C-C Motif Chemokine Ligand 2 (MCP-1) and C-C Motif Chemokine Ligand 5 (RANTES) across the Intact Mouse Blood-Brain Barrier Is Inhibited by Heparin and Eprodisate and Increased with Systemic Inflammation

  2022cites this paper
• Beyond barrier functions: Roles of pericytes in homeostasis and regulation of neuroinflammation

  2020cites this paper
• Low serum levels of fibroblast growth factor 2 in Gunn rats: a hyperbilirubinemia animal model of schizophrenic symptoms.

  2020cites this paper
• Basement Membrane Changes in Ischemic Stroke

  2020cites this paper
• Sulfated syndecan 1 is critical to preventing cellular senescence by modulating fibroblast growth factor receptor endocytosis

  2020cites this paper
• An astrocyte derived extracellular matrix coating reduces astrogliosis surrounding chronically implanted microelectrode arrays in rat cortex.

  2018cites this paper
• Decreased levels of serum fibroblast growth factor-2 in children with autism spectrum disorder.

  2017cites this paper
• NG2/CSPG4 and progranulin in the posttraumatic glial scar.

  2017cites this paper
• astrocyte derived extracellular matrix coating reduces astrogliosis surrounding chronically implanted microelectrode arrays in rat cortex

  2017cites this paper
• Synthesis and deposition of basement membrane proteins by primary brain capillary endothelial cells in a murine model of the blood–brain barrier

  2017cites this paper
• Apo E-Functionalization of Solid Lipid Nanoparticles Enhances Brain Drug Delivery: Uptake Mechanism and Transport Pathways.

  2017cites this paper
• The vascular basement membrane in the healthy and pathological brain

  2017cites this paper
• Real-time acquisition of transendothelial electrical resistance in an all-human, in vitro, 3-dimensional, blood–brain barrier model exemplifies tight-junction integrity

  2017cites this paper
• Spinal Cord Injury Changes Cytokine Transport.

  2016cites this paper
• Hippocampal proteomic and metabonomic abnormalities in neurotransmission and oxidative stress pathways in a chronic phencyclidine rat model

  2016cites this paper
• Apicobasal polarity of brain endothelial cells

  2016cites this paper
• Immortalized endothelial cell lines for in vitro blood-brain barrier models: A systematic review.

  2016influential citation
• Hippocampal Proteomic and Metabonomic Abnormalities in Neurotransmission, Oxidative Stress, and Apoptotic Pathways in a Chronic Phencyclidine Rat Model.

  2015cites this paper
• Systemic administration of fibroblast growth factor-2 (FGF2) reduces BACE1 expression and amyloid pathology in APP23 mice.

  2015cites this paper
• Investigating the role of perlecan domain V in post-ischemic cerebral angiogenesis.

  2014cites this paper
• Targeted Discovery and Validation of Plasma Biomarkers of Parkinson’s Disease

  2014cites this paper
• Perlecan regulates bidirectional Wnt signaling at the Drosophila neuromuscular junction

  2013cites this paper
• Chapter 230 – Neurotrophic Peptides

  2013cites this paper
• Perlecan and the Blood-Brain Barrier: Beneficial Proteolysis?

  2012cites this paper
• Quantitative immunohistochemical analysis of human brain basic fibroblast growth factor, glial fibrillary acidic protein and single-stranded DNA expressions following traumatic brain injury.

  2012cites this paper
• Immunohistochemistry of Neuronal Apoptosis in Fatal Traumas: The Contribution of Forensic Molecular Pathology in Medical Science

  2012influential citation
• Targeted Drug Delivery Across Blood-Brain-Barrier Using Cell Penetrating Peptides Tagged Nanoparticles

  2011cites this paper
• Localization of brain endothelial luminal and abluminal transporters with immunogold electron microscopy

  2011cites this paper
• Evaluation of human brain damage in fire fatality by quantification of basic fibroblast growth factor (bFGF), glial fibrillary acidic protein (GFAP) and single-stranded DNA (ssDNA) immunoreactivities.

  2011cites this paper
• The C NS microvascular pericyte: pericyte- astrocyte crosstalk in the regulation of tissue

  2011cites this paper
• Multifunctional Nanocarriers for diagnostics, drug delivery and targeted treatment across blood-brain barrier: perspectives on tracking and neuroimaging

  2010cites this paper
• Association of the HSPG2 Gene with Neuroleptic-Induced Tardive Dyskinesia

  2010cites this paper
• Perlecan/Hspg2 Deficiency Alters the Pericellular Space of the Lacunocanalicular System Surrounding Osteocytic Processes in Cortical Bone

  2010cites this paper
• Wirkungen der Gerinnungsfaktoren Thrombin und Faktor-Xa auf vaskuläre Zellen des Menschen

  2008cites this paper
• ATP-binding cassette transporter A1 (ABCA1) deficiency does not attenuate the brain-to-blood efflux transport of human amyloid-beta peptide (1-40) at the blood-brain barrier.

  2008cites this paper
• The proteoglycan perlecan regulates long bone growth through interactions with developmental proteins in the growth plate

  2007cites this paper
• Heparan and chondroitin sulfate on growth plate perlecan mediate binding and delivery of FGF-2 to FGF receptors.

  2007cites this paper
• 4.17 – Multiple Species and Functions of Proteoglycans in the Central Nervous System

  2007cites this paper
• Cytokines Interact with the Blood‐Brain Barrier

  2007cites this paper
• Transport of Basic Peptides at the Blood–Brain Barrier

  2006cites this paper
• Receptor-mediated transport of LIF across blood-spinal cord barrier is upregulated after spinal cord injury.

  2006cites this paper
• Intracellular trafficking in neurones and glia of fibroblast growth factor‐2, fibroblast growth factor receptor 1 and heparan sulphate proteoglycans in the injured adult rat cerebral cortex

  2006cites this paper
• Fibroblast Growth Factor and the Blood–Brain Barrier

  2006cites this paper
• Permeability of the Blood—Brain Barrier to Neurotrophic Peptides

  2006cites this paper
• Normal and Pathologically Altered Structures of the Choroid Plexus

  2005cites this paper
• Transport of transforming growth factor-beta 2 across the blood-brain barrier.

  2005cites this paper
• Genomes & Developmental Control Computational analysis of EGFR inhibition by Argos

  2005cites this paper
• Permeation of growth hormone across the blood-brain barrier.

  2005cites this paper
• Computational analysis of EGFR inhibition by Argos.

  2005cites this paper
• Specific Structural Features of Heparan Sulfate Proteoglycans Potentiate Neuregulin-1 Signaling*

  2005cites this paper
• Basic fibroblast growth factor suppresses p53 activation in the neoplastic cells of a proportion of patients with chronic lymphocytic leukaemia

  2005cites this paper
• An apolipoprotein E-derived peptide mediates uptake of sterically stabilized liposomes into brain capillary endothelial cells.

  2005cites this paper
• Functional expression of rat ABCG2 on the luminal side of brain capillaries and its enhancement by astrocyte‐derived soluble factor(s)

  2004cites this paper
• Poly(β-amino ester)s Promote Cellular Uptake of Heparin and Cancer Cell Death

  2004cites this paper
• Thrombin- and Factor Xa–Induced DNA Synthesis Is Mediated by Transactivation of Fibroblast Growth Factor Receptor-1 in Human Vascular Smooth Muscle Cells

  2004cites this paper
• Poly(beta-amino ester)s promote cellular uptake of heparin and cancer cell death.

  2004cites this paper
• Why study transport of peptides and proteins at the neurovascular interface.

  2004cites this paper
• Contribution of Proteoglycans to Human Immunodeficiency Virus Type 1 Brain Invasion

  2004cites this paper
• Increased levels of serum basic fibroblast growth factor in schizophrenia.

  2003cites this paper
• Blood-brain barrier transport of a novel micro 1-specific opioid peptide, H-Tyr-D-Arg-Phe-beta-Ala-OH (TAPA).

  2003cites this paper
• Blood–brain barrier transport of a novel µ1‐specific opioid peptide, H‐Tyr‐d‐Arg‐Phe‐β‐Ala‐OH (TAPA)

  2003cites this paper
• Application of in vivo brain microdialysis to the study of blood-brain barrier transport of drugs.

  2002cites this paper
• The brain's interstitial clefts and their glial walls

  2002cites this paper