GPR26-deficient mice display increased anxiety- and depression-like behaviors accompanied by reduced phosphorylated cyclic AMP responsive element-binding protein level in central amygdala.

No abstract is available for this paper.

• Publication year

  2011

• Venue

  Neuroscience

• Publication date

  2011-11-24

• Fields of study

  Biology, Medicine, Psychology

• Identifiers
  DOI 10.1016/j.neuroscience.2011.08.069PMID 21924326
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

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  2007influential reference
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  2007cited by this paper
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  2005influential reference
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  2002influential reference
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  2001cited by this paper
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  2001cited by this paper
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  1999cited by this paper
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  1998cited by this paper
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  1998cited by this paper
• CREB and memory.

  1998cited by this paper
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  1998cited by this paper
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  1997cited by this paper
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  1996cited by this paper
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  1996cited by this paper
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  1995cited by this paper
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  1995cited by this paper
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  1994cited by this paper
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  1990cited by this paper
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  1990cited by this paper
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  1989cited by this paper
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  1988cited by this paper
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  1977cited by this paper
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  1976cited by this paper
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  1973cited by this paper

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