Modeling NF2 with human arachnoidal and meningioma cell culture systems: NF2 silencing reflects the benign character of tumor growth.

No abstract is available for this paper.

• Publication year

  2008

• Venue

  Neurobiology of Disease

• Publication date

  2008-02-01

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1016/J.NBD.2007.09.002PMID 17962031PMCID PMC2266821
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• On arachnoid villi and meningiomas: Functional implication of ultrastructure, cell adhesion mechanisms, and extracellular matrix composition

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• Tumors of the Nervous System

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• The 2007 WHO Classification of Tumours of the Central Nervous System

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• A negative feedback signaling network underlies oncogene-induced senescence.

  2006cited by this paper
• The signals and pathways activating cellular senescence.

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• The NF2 Tumor Suppressor Gene Product, Merlin, Inhibits Cell Proliferation and Cell Cycle Progression by Repressing Cyclin D1 Expression

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• Membrane organization and tumorigenesis--the NF2 tumor suppressor, Merlin.

  2005influential reference
• Management of the patient and family with neurofibromatosis 2: a consensus conference statement

  2005cited by this paper
• Merlin/NF-2 mediates contact inhibition of growth by suppressing recruitment of Rac to the plasma membrane

  2005influential reference
• Crucial role of p53-dependent cellular senescence in suppression of Pten-deficient tumorigenesis

  2005cited by this paper
• Tumour biology: Senescence in premalignant tumours

  2005cited by this paper
• Rearrangements of the intermediate filament GFAP in primary human schwannoma cells.

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• A NHERF binding site links the βPDGFR to the cytoskeleton and regulates cell spreading and migration

  2004cited by this paper
• Magicin, a novel cytoskeletal protein associates with the NF2 tumor suppressor merlin and Grb2

  2004cited by this paper
• Brain tumours: classification and genes

  2004cited by this paper
• Molecular pathogenesis of meningiomas

  2004cited by this paper
• Optimized large-scale production of high titer lentivirus vector pseudotypes.

  2004cited by this paper
• Meningioma Pathology, Genetics, and Biology

  2004cited by this paper
• Ezrin regulates E-cadherin-dependent adherens junction assembly through Rac1 activation.

  2003cited by this paper
• Telomerase in intracranial meningiomas.

  2003cited by this paper
• Lentivirus-delivered stable gene silencing by RNAi in primary cells.

  2003influential reference
• Multiple meningiomas: Investigating the molecular basis of sporadic and familial forms

  2003cited by this paper
• NF2 deficiency promotes tumorigenesis and metastasis by destabilizing adherens junctions.

  2003influential reference
• Upregulation of the Rac1/JNK signaling pathway in primary human schwannoma cells.

  2003cited by this paper
• The Neurofibromatosis Type 2 Gene Product, merlin, Reverses the F-Actin Cytoskeletal Defects in Primary Human Schwannoma Cells

  2002cited by this paper
• Protein 4.1 tumor suppressors: getting a FERM grip on growth regulation

  2002cited by this paper
• The WHO Classification of Tumors of the Nervous System

  2002cited by this paper
• Nf2 gene inactivation in arachnoidal cells is rate-limiting for meningioma development in the mouse.

  2002cited by this paper
• Cellular transformation by a FERM domain mutant of the Nf2 tumor suppressor gene

  2002cited by this paper
• ERM proteins and merlin: integrators at the cell cortex

  2002cited by this paper
• Mouse models of neurofibromatosis 1 and 2.

  2002cited by this paper
• The Nf2 tumor suppressor, merlin, functions in Rac-dependent signaling.

  2001cited by this paper
• Elevated p53 expression in benign meningiomas protects against recurrence and may be indicative of senescence

  2001cited by this paper
• The NF2 tumor suppressor gene product, merlin, mediates contact inhibition of growth through interactions with CD44.

  2001cited by this paper
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  2001cited by this paper
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  2001cited by this paper
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  2000cited by this paper
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  2000cited by this paper
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  1999cited by this paper
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  1999cited by this paper
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  1999cited by this paper
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  1999cited by this paper
• Expression of β1 and β4 integrins in normal arachnoid membrane and meningiomas

  1999cited by this paper
• Rho GTPases and the actin cytoskeleton.

  1998influential reference
• Regulation of the Neurofibromatosis Type 2 Tumor Suppressor Protein, Merlin, by Adhesion and Growth Arrest Stimuli*

  1998cited by this paper
• Ruffling membrane, stress fiber, cell spreading and proliferation abnormalities in human Schwannoma cells

  1998cited by this paper
• Mice heterozygous for a mutation at the Nf2 tumor suppressor locus develop a range of highly metastatic tumors.

  1998cited by this paper
• Isolation and characterization of Schwann cells from neurofibromatosis type 2 patients.

  1998cited by this paper
• The diagnostic evaluation and multidisciplinary management of neurofibromatosis 1 and neurofibromatosis 2.

  1997cited by this paper
• Role of Actin Polymerization and Adhesion to Extracellular Matrix in Rac- and Rho-induced Cytoskeletal Reorganization

  1997cited by this paper
• Frequency and distribution of NF2 mutations in schwannomas

  1996cited by this paper
• The merlin tumor suppressor localizes preferentially in membrane ruffles.

  1996cited by this paper
• Distinct cellular and subcellular patterns of expression imply distinct functions for the Drosophila homologues of moesin and the neurofibromatosis 2 tumor suppressor, merlin

  1996cited by this paper
• The neurofibromatosis type 2 gene product, schwannomin, suppresses growth of NIH 3T3 cells.

  1995cited by this paper
• A biomarker that identifies senescent human cells in culture and in aging skin in vivo.

  1995influential reference
• Primary culture of human leptomeningeal cells in serum-free medium.

  1994cited by this paper
• Expression of epithelial and extracellular matrix protein markers in meningiomas

  1993cited by this paper
• A novel moesin-, ezrin-, radixin-like gene is a candidate for the neurofibromatosis 2 tumor suppressor.

  1993cited by this paper
• Alteration in a new gene encoding a putative membrane-organizing protein causes neuro-fibromatosis type 2

  1993influential reference
• The small GTP-binding protein rac regulates growth factor-induced membrane ruffling.

  1992cited by this paper
• Molecular genetic approach to human meningioma: loss of genes on chromosome 22.

  1987cited by this paper
• Characterization of normal human brain cultures. Evidence for the outgrowth of leptomeningeal cells.

  1986cited by this paper
• Cytokeratin provides a specific marker for human arachnoid cells grown in vitro.

  1983cited by this paper

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  2023cites this paper
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  2021cites this paper
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