Aqueous cannabidiol β-cyclodextrin complexed polymeric micelle nasal spray to attenuate in vitro and ex vivo SARS-CoV-2-induced cytokine storms

Graphical abstract

• Publication year

  2023

• Venue

  International journal of pharmaceutics

• Publication date

  2023-05-01

• Fields of study

  Medicine, Chemistry

• Identifiers
  DOI 10.1016/j.ijpharm.2023.123035PMID 37182795PMCID 10181874
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Formulation, design and strategies for efficient nanotechnology-based nasal delivery systems

  2022influential reference
• Cannabidiol As a Treatment for COVID-19 Symptoms? A Critical Review

  2022cited by this paper
• A Review of Polymeric Micelles and Their Applications

  2022cited by this paper
• Pharmacokinetics of Cannabidiol Following Intranasal, Intrarectal, and Oral Administration in Healthy Dogs

  2022cited by this paper
• COVID-19 infection: an overview on cytokine storm and related interventions

  2022cited by this paper
• Anti-Inflammatory and Antiviral Effects of Cannabinoids in Inhibiting and Preventing SARS-CoV-2 Infection

  2022cited by this paper
• Drug-Free Nasal Spray as a Barrier against SARS-CoV-2 and Its Delta Variant: In Vitro Study of Safety and Efficacy in Human Nasal Airway Epithelia

  2022cited by this paper
• Biophysical Studies and In Vitro Effects of Tumor Cell Lines of Cannabidiol and Its Cyclodextrin Inclusion Complexes

  2022cited by this paper
• Cannabidiol and SARS-CoV-2 Infection

  2022cited by this paper
• Strategies to Improve Drug Strength in Nasal Preparations for Brain Delivery of Low Aqueous Solubility Drugs

  2022cited by this paper
• Cannabidiol/hydroxypropyl-β-cyclodextrin inclusion complex: Structure analysis, release behavior, permeability, and bioactivity under in-vitro digestion

  2022cited by this paper
• Development of In Vitro Evaluation System for Assessing Drug Dissolution Considering Physiological Environment in Nasal Cavity

  2022cited by this paper
• Oral inhalation of cannabidiol delivered from a metered dose inhaler to alleviate cytokine production induced by SARS-CoV-2 and pollutants

  2022cited by this paper
• An Updated Overview of Cyclodextrin-Based Drug Delivery Systems for Cancer Therapy

  2022influential reference
• Mucosal Vaccine Delivery Using Mucoadhesive Polymer Particulate Systems

  2021influential reference
• Current trends on cannabidiol delivery systems: where are we and where are we going?

  2021cited by this paper
• Inclusion complexes of cannabidiol with β-cyclodextrin and its derivative: Physicochemical properties, water solubility, and antioxidant activity

  2021influential reference
• Drug-free nasal spray as a barrier against SARS-CoV-2 infection: safety and efficacy in human nasal airway epithelia

  2021cited by this paper
• Polymeric micelles in drug delivery: An insight of the techniques for their characterization and assessment in biorelevant conditions.

  2021cited by this paper
• Main Applications of Cyclodextrins in the Food Industry as the Compounds of Choice to Form Host–Guest Complexes

  2021cited by this paper
• Cannabis compounds exhibit anti-inflammatory activity in vitro in COVID-19-related inflammation in lung epithelial cells and pro-inflammatory activity in macrophages

  2021cited by this paper
• Formulation of a Composite Nasal Spray Enabling Enhanced Surface Coverage and Prophylaxis of SARS‐COV‐2

  2021cited by this paper
• Cyclodextrins: Structural, Chemical, and Physical Properties, and Applications

  2021cited by this paper
• Highly Enhanced Curcumin Delivery Applying Association Type Nanostructures of Block Copolymers, Cyclodextrins and Polycyclodextrins

  2020influential reference
• Cyclodextrin Complexation Improves the Solubility and Caco-2 Permeability of Chrysin

  2020cited by this paper
• The potential of cannabidiol in the COVID‐19 pandemic

  2020cited by this paper
• COVID-19 cytokine storm: The anger of inflammation

  2020cited by this paper
• A serological assay to detect SARS-CoV-2 seroconversion in humans

  2020cited by this paper
• Cannabidiol

  2020cited by this paper
• A novel combination of Soluplus® and Poloxamer for Meloxicam solid dispersions via hot melt extrusion for rapid onset of action—part 1: dissolution and stability studies

  2020cited by this paper
• Critical Determinants of Cytokine Storm and Type I Interferon Response in COVID-19 Pathogenesis

  2020cited by this paper
• Cannabidiol aqueous solubility enhancement: comparison of three amorphous formulations strategies using different type of polymers.

  2020influential reference
• Fatty acid profile of Romanian’s common bean (Phaseolus vulgaris L.) lipid fractions and their complexation ability by β-cyclodextrin

  2019influential reference
• Cyclodextrin–Drug Inclusion Complexes: In Vivo and In Vitro Approaches

  2019cited by this paper
• Structural analysis and cytotoxicity of host-guest inclusion complexes of cannabidiol with three native cyclodextrins

  2019influential reference
• β-Cyclodextrin as a Functional Excipient Used for Enhancing the Diminazene Aceturate Bioavailability

  2019influential reference
• Inclusion Complexes of β and HPβ-Cyclodextrin with α, β Amyrin and In Vitro Anti-Inflammatory Activity

  2019influential reference
• Solubilization of Phytocannabinoids Using Cyclodextrins

  2019influential reference
• Cyclodextrins: Emerging Medicines of the New Millennium

  2019cited by this paper
• Cyclodextrins in Drug Delivery Systems and Their Effects on Biological Barriers

  2019cited by this paper
• Nanotechnology-Based Targeted Drug Delivery Systems for Lung Cancer

  2019cited by this paper
• A review on thermal analyses of cyclodextrins and cyclodextrin complexes

  2018cited by this paper
• Physicochemical properties of β-cyclodextrin solutions and precipitates prepared from injectable vehicles

  2018influential reference
• Feasibility Investigation of Cellulose Polymers for Mucoadhesive Nasal Drug Delivery Applications.

  2015cited by this paper
• Cyclodextrins and surfactants in aqueous solution above the critical micelle concentration: where are the cyclodextrins located?

  2014cited by this paper
• Background review for cyclodextrins used as excipients

  2014cited by this paper
• Development and Characterization of Lyophilized Diazepam-Loaded Polymeric Micelles

  2013cited by this paper
• Considerations for the Development of Nasal Dosage Forms

  2013influential reference
• Handbook of Pharmaceutical Excipients – 7th Edition

  2013cited by this paper
• An Ex Vivo Porcine Nasal Mucosa Explants Model to Study MRSA Colonization

  2013cited by this paper
• Poloxamer 407/TPGS mixed micelles for delivery of gambogic acid to breast and multidrug-resistant cancer

  2012cited by this paper
• A review on factors affecting the design of nasal drug delivery system

  2011cited by this paper
• Pharmaceutical applications of cyclodextrins: basic science and product development

  2010cited by this paper
• Cannabidiol bioavailability after nasal and transdermal application: effect of permeation enhancers

  2010cited by this paper
• Lipid rafts are involved in SARS-CoV entry into Vero E6 cells

  2008cited by this paper
• The diverse CB1 and CB2 receptor pharmacology of three plant cannabinoids: Δ9‐tetrahydrocannabinol, cannabidiol and Δ9‐tetrahydrocannabivarin

  2008cited by this paper
• Solubility of β-cyclodextrin in different mixed solvents

  2008cited by this paper
• The diverse CB1 and CB2 receptor pharmacology of three plant cannabinoids: delta9-tetrahydrocannabinol, cannabidiol and delta9-tetrahydrocannabivarin.

  2008cited by this paper
• Bioavailability of intranasal drug delivery system

  2008cited by this paper
• Precipitation complexation method produces cannabidiol/beta-cyclodextrin inclusion complex suitable for sublingual administration of cannabidiol.

  2007cited by this paper
• A Review of Poloxamer 407 Pharmaceutical and Pharmacological Characteristics

  2006cited by this paper
• Martin's physical pharmacy and pharmaceutical sciences : physical chemical and biopharmaceutical principles in the pharmaceutical sciences

  2006influential reference
• Polymeric micelles for drug delivery

  2006cited by this paper
• Available online at

  2006cited by this paper
• Cyclodextrins in drug delivery

  2005cited by this paper
• Martin's Physical Pharmacy and Pharmaceutical Sciences

  2005cited by this paper
• Human skin permeation of Δ8‐tetrahydrocannabinol, cannabidiol and cannabinol

  2004influential reference
• Human skin permeation of Delta8-tetrahydrocannabinol, cannabidiol and cannabinol.

  2004cited by this paper
• Pluronic block copolymers as novel polymer therapeutics for drug and gene delivery.

  2002cited by this paper
• Development of In-Vitro Evaluation System for Annuloplasty Rings

  2001cited by this paper
• Determination of baseline human nasal pH and the effect of intranasally administered buffers.

  2000cited by this paper
• Introduction to spectroscopy : a guide for students of organic chemistry

  1996cited by this paper
• Solubility behavior of .beta.-cyclodextrin in water/cosolvent mixtures

  1992cited by this paper
• A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding.

  1976cited by this paper
• A serological assay to detect SARS-CoV-2 seroconversion in humans 1

  year unknowncited by this paper

• Cyclodextrin-Based Nanotransporters as a Versatile Tool to Manage Oxidative Stress-Induced Lung Diseases

  2025cites this paper
• Utilization of Cannabidiol in Post-Organ-Transplant Care

  2025influential citation
• Therapeutic Potential of Cannabidiol Cyclodextrin Complex in Polymeric Micelle and Tetrahydrocurcumin Cyclodextrin Complex Loaded in Hydrogel to Treat Lymphedema

  2025influential citation
• Solubilising and Aerosolising Cannabidiol Using Methyl β-Cyclodextrin and Human Serum Albumin

  2025cites this paper
• Improvement of the Solubility, Permeability, and Pharmacological Activity of Decoquinate-Loaded Hydroxypropyl-β-Cyclodextrin–Tea Saponins Ternary ComplexA

  2025cites this paper
• Current insights into polymeric micelles for nasal drug delivery

  2025cites this paper
• Inhalation of 2, 4-Di-tert-butylphenol-Loaded Micelles Suppresses Respiratory Syncytial Virus Infection in Mice.

  2024cites this paper
• Tailoring micellar nanocarriers for pemetrexed in breast cancer: design, fabrication and in vitro evaluation.

  2024cites this paper
• BrSPR-20-P1 peptide isolated from Brevibacillus sp. developed into liposomal hydrogel as a potential topical antimicrobial agent

  2024cites this paper
• Advances in Polysaccharide-Based Formulations for Intranasal Drug Delivery: A Review

  2024cites this paper
• Polysaccharide-based platforms for nasal delivery: design, features, and perspectives

  2023cites this paper
• Assessing the Anti-Aging and Wound Healing Capabilities of Etlingera elatior Inflorescence Extract: A Comparison of Three Inflorescence Color Varieties

  2023cites this paper