Mannose-binding lectin gene 2 variant DD (rs 5030737) is associated with susceptibility to COVID-19 infection in the urban population of Patna City (India)

The study aimed to measure plasma levels of Mannose-Binding Lectin (MBL) and MBL-associated serine protease-2 (MASP-2) and their polymorphisms in COVID-19 patients and controls to detect association. As MBL is a protein of immunological importance, it may contribute to the first-line host defence against SARS-CoV-2. MBL initiates the lectin pathway of complement activation with help of MASP-1 and MASP-2. Hence, appropriate serum levels of MBL and MASPs are crucial in getting protection from the disease. The polymorphisms of MBL and MASP genes affect their plasma levels, impacting their protective function and thus may manifest susceptibility, extreme variability in the clinical symptoms and progression of COVID-19 disease. The present study was conducted to find plasma levels and genetic variations in MBL and MASP-2 in COVID-19 patients and controls using PCR–RFLP and ELISA, respectively.The present study was conducted to find plasma levels and genetic variations in MBL and MASP-2 in COVID-19 patients and controls using PCR–RFLP and ELISA, respectively. Our results indicate that median serum levels of MBL and MASP-2 were significantly low in diseased cases but attained normal levels on recovery. Only genotype DD was found to be associated with COVID-19 cases in the urban population of Patna city.

• Publication year

  2023

• Venue

  Zeitschrift für Induktive Abstammungs- und Vererbungslehre

• Publication date

  2023-05-18

• Fields of study

  Medicine

• Identifiers
  DOI 10.1007/s00438-023-02030-4PMID 37204457PMCID 10196310
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Highly pathogenic coronavirus N protein aggravates inflammation by MASP-2-mediated lectin complement pathway overactivation

  2022cited by this paper
• Mannose binding lectin gene 2 (rs1800450) missense variant may contribute to development and severity of COVID-19 infection

  2021cited by this paper
• How glycobiology can help us treat and beat the COVID-19 pandemic

  2021cited by this paper
• The ambiguous role of mannose-binding lectin (MBL) in human immunity

  2021cited by this paper
• Lectin Pathway Mediates Complement Activation by SARS-CoV-2 Proteins

  2021cited by this paper
• Genetic Risk Factors for the Development of COVID-19 Coronavirus Infection

  2021cited by this paper
• Mannose-Binding Lectin is Associated with Thrombosis and Coagulopathy in Critically Ill COVID-19 Patients

  2020cited by this paper
• Predicting Hospital Utilization and Inpatient Mortality of Patients Tested for COVID-19

  2020cited by this paper
• Low Mannose Binding Lectin, but Not L-Ficolin, Is Associated With Spontaneous Clearance of Hepatitis C Virus After Infection

  2020cited by this paper
• Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and coronavirus disease-2019 (COVID-19): The epidemic and the challenges

  2020cited by this paper
• Complement associated microvascular injury and thrombosis in the pathogenesis of severe COVID-19 infection: A report of five cases

  2020cited by this paper
• Extensive Acute Lower Extremity Arterial Thrombosis: A Major Thrombus Formation Caused by COVID-19

  2020cited by this paper
• The first, holistic immunological model of COVID‐19: Implications for prevention, diagnosis, and public health measures

  2020cited by this paper
• EAACI Allergen Immunotherapy User's Guide

  2020cited by this paper
• Effects of MASP2 haplotypes and MASP‐2 levels in hepatitis C‐infected patients

  2018cited by this paper
• Prospective Observational Study on the Association Between Serum Mannose-Binding Lectin Levels and Severe Outcome in Critically Ill Patients with Pandemic Influenza Type A (H1N1) Infection

  2017cited by this paper
• Functional polymorphisms of the CCL2 and MBL genes cumulatively increase susceptibility to severe acute respiratory syndrome coronavirus infection

  2015cited by this paper
• Association of MASP-2 Levels and MASP2 Gene Polymorphisms with Rheumatoid Arthritis in Patients and Their Relatives

  2014cited by this paper
• Functional Polymorphisms in the

  2013cited by this paper
• Polymorphisms in the MASP1 Gene Are Associated with Serum Levels of MASP-1, MASP-3, and MAp44

  2013cited by this paper
• Revised mechanism of complement lectin-pathway activation revealing the role of serine protease MASP-1 as the exclusive activator of MASP-2

  2012cited by this paper
• Genetic polymorphisms and serum levels of mannose-binding lectin in Chinese pediatric patients with common infectious diseases.

  2012cited by this paper
• MASP2 gene polymorphism is associated with susceptibility to hepatitis C virus infection

  2011cited by this paper
• Multiplex sequence-specific polymerase chain reaction reveals new MASP2 haplotypes associated with MASP-2 and MAp19 serum levels.

  2011cited by this paper
• Acute‐phase responsiveness of mannose‐binding lectin in community‐acquired pneumonia is highly dependent upon MBL2 genotypes

  2009cited by this paper
• Uptake of meningococcal conjugate vaccine among adolescents in large managed care organizations, United States, 2005: Demand, supply and seasonality

  2009cited by this paper
• Lack of association between polymorphisms of MASP2 and susceptibility to SARS coronavirus infection

  2009cited by this paper
• Deficiency of mannan-binding lectin associated serine protease-2 due to missense polymorphisms

  2007cited by this paper
• Severe Acute Respiratory Syndrome Coronavirus Infection in Vaccinated Ferrets

  2007cited by this paper
• SNPassoc: an R package to perform whole genome association studies

  2007cited by this paper
• Mannose-binding lectin and its genetic variants

  2006cited by this paper
• Association of mannose binding lectin (MBL) gene polymorphism and serum MBL concentration with characteristics and progression of systemic lupus erythematosus

  2005cited by this paper
• Mannose-Binding Lectin in Severe Acute Respiratory Syndrome Coronavirus Infection

  2005cited by this paper
• Association between Mannose-Binding Lectin Gene Polymorphisms and Susceptibility to Severe Acute Respiratory Syndrome Coronavirus Infection

  2005cited by this paper
• Disease-associated Mutations in Human Mannose-binding Lectin Compromise Oligomerization and Activity of the Final Protein*

  2004cited by this paper
• Serum Mannose‐Binding Lectin Levels and mbl2 Gene Polymorphisms in Different Age and Gender Groups of Southern Chinese Adults

  2004cited by this paper
• Inherited deficiency of mannan-binding lectin-associated serine protease 2.

  2003cited by this paper
• Impact of mannose-binding lectin on susceptibility to infectious diseases.

  2003cited by this paper
• Genetic polymorphisms.

  2002cited by this paper
• Two genetic hits (more or less) to cancer

  2001cited by this paper
• Association

  1973cited by this paper

• Association between MASP2 gene polymorphisms and susceptibility to Covid-19 in Iranian patients: a case-control study

  2025influential citation
• Genomic Landscape of Susceptibility to Severe COVID-19 in the Slovenian Population

  2024cites this paper