Cingulin and paracingulin tether myosins-2 to junctions to mechanoregulate the plasma membrane

Rouaud et al. show that cingulin and paracingulin bind to specific myosin-2 isoforms through coiled-coil rod-mediated interactions and tether them to junctions to transmit force and modulate ZO-1 junctional accumulation, tight junction membrane tortuosity, apical membrane stiffness, and junctional architecture.

• Publication year

  2023

• Venue

  Journal of Cell Biology

• Publication date

  2023-05-19

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1083/jcb.202208065PMID 37204781PMCID 10202830
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

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