Signaling is the pathway to macrophage function.

Rachel A. Gottschalk

Published 2023 in Trends in immunology

ABSTRACT

Tissue and inflammatory contexts are well appreciated to shape macrophage function to promote health or disease. However, there has been minimal progress towards understanding how these contexts modify signaling-to-transcription networks. Integration of mechanistic modeling and data-driven approaches will be crucial for investigating how cell state impacts macrophage decision-making.

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