Transgene Rescue Identifies an Essential Function for Drosophila β Spectrin in the Nervous System and a Selective Requirement for Ankyrin-2–binding Activity

The Gal4-UAS system was used to overexpress or knock down β spectrin with dsRNA in a variety of Drosophila tissues. Unexpectedly, overexpression in most tissues tested was lethal, whereas knockdown failed to produce a detectable phenotype in the same tissues. The lethality of a β spectrin mutation was rescued by expression of β spectrin in neurons.

• Publication year

  2010

• Venue

  Molecular Biology of the Cell

• Publication date

  2010-08-15

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1091/mbc.E10-03-0180PMID 20573981PMCID 2921109
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

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