The Role of Membrane Lipids in the Formation and Function of Caveolae.

A. Kenworthy,Bing Han,N. Ariotti,R. Parton

Published 2023 in Cold Spring Harbor Perspectives in Biology

ABSTRACT

Caveolae are plasma membrane invaginations with a distinct lipid composition. Membrane lipids cooperate with the structural components of caveolae to generate a metastable surface domain. Recent studies have provided insights into the structure of essential caveolar components and how lipids are crucial for the formation, dynamics, and disassembly of caveolae. They also suggest new models for how caveolins, major structural components of caveolae, insert into membranes and interact with lipids.

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