Recurrent Hyponatremia in the Setting of Autoimmune Disease with Sicca Syndrome: A Case Report

Sjogren’s syndrome is an autoimmune disease associated with xerostomia and xerophthalmia. The association of Sjogren’s with hyponatremia has rarely been reported and has been attributed to syndrome of inappropriate antidiuretic hormone secretion. Here, we report a case of polydipsia secondary to xerostomia as a cause of chronic hyponatremia in the setting of Sjogren’s syndrome. Analysis of the patient’s medical record, including medication reconciliation and dietary habits, revealed several underlying causes of her recurrent hyponatremia. A thorough review of the patient’s clinical history and good bedside examination may reduce prolonged hospitalizations and improve the quality of life of a hyponatremic population of patients who are predominantly elderly.

• Publication year

  2023

• Venue

  Case Reports in Nephrology and Dialysis

• Publication date

  2023-06-21

• Fields of study

  Medicine

• Identifiers
  DOI 10.1159/000530491PMID 37384122PMCID 10294280
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Recurrent Severe Hyponatremia in a Patient with Sjögren's Syndrome

  2020cited by this paper
• Primary Sjögren’s Syndrome.

  2018cited by this paper
• Primary Sjögren's Syndrome

  2018cited by this paper
• Treatment of Severe Hyponatremia.

  2018influential reference
• “Beer Potomania” – A Syndrome of Severe Hyponatremia with Unique Pathophysiology: Case Studies and Literature Review

  2017cited by this paper
• Renal involvement in primary Sjögren syndrome

  2016cited by this paper
• Chronic Hyponatremia Causes Neurologic and Psychologic Impairments.

  2016cited by this paper
• Inflammation and hyponatremia: an underrecognized condition?

  2013cited by this paper
• Clinical physiology of acid-base and electrolyte

  2012cited by this paper
• Managing the patient presenting with xerostomia: a review

  2010cited by this paper
• Cytokines in Sjögren's syndrome.

  2009cited by this paper
• Overcorrection of hyponatremia is a medical emergency.

  2009cited by this paper
• Mild hyponatremia and risk of fracture in the ambulatory elderly.

  2008cited by this paper
• The significance of salivary and serum interleukin 6 and basic fibroblast growth factor levels in patients with Sjögren's syndrome.

  2004cited by this paper
• Hypothalamic-pituitary-adrenal axis activation and stimulation of systemic vasopressin secretion by recombinant interleukin-6 in humans: potential implications for the syndrome of inappropriate vasopressin secretion.

  1994cited by this paper
• Primary Sjögren's syndrome associated with inappropriate antidiuretic hormone secretion. A case report.

  1991cited by this paper
• Primary Sjögren's syndrome (SS) with inappropriate antidiuretic hormone secretion (SIADH).

  1989cited by this paper

• Severe Xerostomia Induced by Multiple Systemic Diseases in a Patient with Psoriasis Vulgaris: A Case Report and Literature Review

  2024cites this paper