Viscum Album - Literature Review

Viscum album L., popularly known as "Mistletoe", is considered a semi-parasitic plant that grows on several host trees. It has a wide variety of biologically active compounds that can be used to treat various diseases, being its most significant indication for the adjuvant treatment of cancer patients. However, little data is found in the literature on the in vitro and in vivo effects of Viscum album(VA), although formulations for commercial use are available, with extremely low doses of its active compounds. Previous studies used anthroposophical VA and provided information on the mechanisms of action of this extract in tumor and immune system cells. Therefore, the objective of this study was to perform a literature review on the VA plant regarding its botanical behavior and action in

• Publication year

  2021

• Venue

  International Journal of Science and Research (IJSR)

• Publication date

  2021-05-27

• Fields of study

  Not labeled

• Identifiers
  DOI 10.21275/sr21430224614
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar

• No claims are published for this paper.

• No concepts are published for this paper.

• Anticancer Effects of Viscum album Fraxini Extract on Medulloblastoma Cells in vitro

  2020cited by this paper
• Long-Term Follow-up of a Randomized Study of Oral Etoposide versus Viscum album Fermentatum Pini as Maintenance Therapy in Osteosarcoma Patients in Complete Surgical Remission after Second Relapse

  2020cited by this paper
• Die Misteltherapie in der Behandlung von Patienten mit einer Krebserkrankung

  2020cited by this paper
• Impact of Oncological Therapy and Viscum album L Treatment on Cancer-Related Fatigue and Internal Coherence in Nonmetastasized Breast Cancer Patients

  2020cited by this paper
• Use of Viscum album in the Integrative Treatment of Cholangiocarcinoma in a Dog (Canis familiaris)- Case Report

  2020cited by this paper
• Preclinical Evaluation of Antitumoral and Cytotoxic Properties of Viscum album Fraxini Extract on Pediatric Tumor Cells

  2019cited by this paper
• Two symmetrical unsaturated acids isolated from Viscum album.

  2019cited by this paper
• Therapeutic potential of mistletoe in CNS-related neurological disorders and the chemical composition of Viscum species.

  2019cited by this paper
• Chemoimmunotherapy in Advanced Renal Cell Carcinoma: A Case Report of a Long-Term Survivor Adjunctly Treated with Viscum album Extracts

  2019cited by this paper
• VISCACEAE: MISTLETOE FAMILY

  2019cited by this paper
• Supportive mistletoe therapy in a patient with metastasised neuroblastoma

  2019influential reference
• Mistletoe extract Fraxini inhibits the proliferation of liver cancer by down-regulating c-Myc expression

  2019cited by this paper
• Mistletoe and Immunomodulation: Insights and Implications for Anticancer Therapies

  2019cited by this paper
• Homeopathy for the Treatment of Transmissible Venereal Tumor (TVT) in a Mixed-Breed Female Dog

  2019cited by this paper
• Mistletoe-Based Drugs Work in Synergy with Radio-Chemotherapy in the Treatment of Glioma In Vitro and In Vivo in Glioblastoma Bearing Mice

  2019cited by this paper
• Antiproliferative potential from aqueous Viscum album L. preparations and their main constituents in comparison with ricin and purothionin on human cancer cells.

  2019cited by this paper
• Three new bioactive flavonoid glycosides from Viscum album.

  2019cited by this paper
• Crystal Structure of Mistletoe Lectin I (ML-I) from Viscum album in Complex with 4-N-Furfurylcytosine at 2.85 Å Resolution.

  2018cited by this paper
• Long-term tumor-free survival in a metastatic pancreatic carcinoma patient with FOLFIRINOX/Mitomycin, high-dose, fever inducing Viscum album extracts and subsequent R0 resection

  2018cited by this paper
• Intralesional and subcutaneous application of Viscum album L. (European mistletoe) extract in cervical carcinoma in situ

  2018cited by this paper
• Phenolic compounds from Viscum album tinctures enhanced antitumor activity in melanoma murine cancer cells

  2018cited by this paper
• Viscum album neutralizes tumor-induced immunosuppression in a human in vitro cell model

  2017cited by this paper
• ViscumTT induces apoptosis and alters IAP expression in osteosarcoma in vitro and has synergistic action when combined with different chemotherapeutic drugs

  2017cited by this paper
• iTRAQ-Based Quantitative Proteomic Analysis of the Inhibitory Effects of Polysaccharides from Viscum coloratum (Kom.) Nakai on HepG2 Cells

  2017cited by this paper
• Synergistic Antitumour Properties of viscumTT in Alveolar Rhabdomyosarcoma

  2017cited by this paper
• Transcriptomic and proteomic insight into the effects of a defined European mistletoe extract in Ewing sarcoma cells reveals cellular stress responses

  2017cited by this paper
• Complete remission and long-term survival of a patient with melanoma metastases treated with high-dose fever-inducing Viscum album extract

  2017cited by this paper
• Antiproliferative effects of extracts from Salvia officinalis L. and Saliva miltiorrhiza Bunge on hepatocellular carcinoma cells.

  2017cited by this paper
• In Silico Template Selection of Short Antimicrobial Peptide Viscotoxin for Improving Its Antimicrobial Efficiency in Development of Potential Therapeutic Drugs

  2017cited by this paper
• Pro-apoptotic and cytotoxic effects of enriched fraction of Elytranthe parasitica (L.) Danser against HepG2 Hepatocellular carcinoma

  2016cited by this paper
• Chemical Constituents of Viscum album L.: Implications for the Pharmaceutical Preparation of Mistletoe

  2015cited by this paper
• A Natural Combination Extract of Viscum album L. Containing Both Triterpene Acids and Lectins Is Highly Effective against AML In Vivo

  2015cited by this paper
• Oleanolic acid induces mitochondrial-dependent apoptosis and G0/G1 phase arrest in gallbladder cancer cells

  2015cited by this paper
• Anti-cancer effects of enteric-coated polymers containing mistletoe lectin in murine melanoma cells in vitro and in vivo

  2015cited by this paper
• Low Doses of Traditional Nanophytomedicines for Clinical Treatment: Manufacturing Processes and Nonlinear Response Patterns.

  2015cited by this paper
• Intratumoral Mistletoe (Viscum album L) Therapy in Patients With Unresectable Pancreas Carcinoma

  2014cited by this paper
• Interaction of standardized mistletoe (Viscum album) extracts with chemotherapeutic drugs regarding cytostatic and cytotoxic effects in vitro

  2014cited by this paper
• Viscum album L. influence on the antioxidant enzymes activity in ehrlich tumor cells in vivo.

  2014cited by this paper
• Diarylheptanoids and flavonoids from viscum album inhibit LPS-stimulated production of pro-inflammatory cytokines in bone marrow-derived dendritic cells.

  2013cited by this paper
• Inhibitory effect of oleanolic acid on hepatocellular carcinoma via ERK-p53-mediated cell cycle arrest and mitochondrial-dependent apoptosis.

  2013cited by this paper
• The immunomodulatory effect of plant lectins: a review with emphasis on ArtinM properties

  2013cited by this paper
• Oleanolic acid arrests cell cycle and induces apoptosis via ROS‐mediated mitochondrial depolarization and lysosomal membrane permeabilization in human pancreatic cancer cells

  2013cited by this paper
• Triterpenoids Amplify Anti-Tumoral Effects of Mistletoe Extracts on Murine B16.F10 Melanoma In Vivo

  2013cited by this paper
• Canine neurofibrosarcoma treatment with Viscum album in serial dilutions

  2013cited by this paper
• Cytotoxic effects of mistletoe (Viscum album L.) in head and neck squamous cell carcinoma cell lines.

  2013cited by this paper
• Recombinant VAA-I from Viscum album Induces Apoptotic Cell Death of Hepatocellular Carcinoma SMMC7721 Cells

  2012cited by this paper
• Novel aminoalkaloids from European mistletoe (Viscum album L.)

  2012cited by this paper
• A Novel Triterpene Extract from Mistletoe Induces Rapid Apoptosis in Murine B16.F10 Melanoma Cells

  2012cited by this paper
• P01.18. Triterpene acid containing Viscum album L. extracts mediate apoptosis in paediatric solid cancer cells

  2012cited by this paper
• The Effects of Viscum album (Mistletoe) QuFrF Extract and Vincristine in Human Multiple Myeloma Cell Lines - A Comparative Experimental Study Using Several and Different Parameters

  2012cited by this paper
• Quality of life, immunomodulation and safety of adjuvant mistletoe treatment in patients with gastric carcinoma – a randomized, controlled pilot study

  2012cited by this paper
• Safety and effects of two mistletoe preparations on production of Interleukin-6 and other immune parameters - a placebo controlled clinical trial in healthy subjects

  2011cited by this paper
• Parasitic Plants of the World

  2011influential reference
• Effects of Viscum album L. extracts in neuroblastoma in vitro and in vivo

  2011cited by this paper
• Extreme homeopathic dilutions retain starting materials: A nanoparticulate perspective

  2010cited by this paper
• Screening of fusion partners for high yield expression and purification of bioactive viscotoxins.

  2009cited by this paper
• Antiangiogenic properties of viscum album extracts are associated with endothelial cytotoxicity.

  2009cited by this paper
• Mistletoe in Conventional Oncological Practice: Exemplary Cases

  2008cited by this paper
• Complementary cancer therapy: a systematic review of prospective clinical trials on anthroposophic mistletoe extracts.

  2007cited by this paper
• Effects of Korean Mistletoe Lectin(Viscum album coloratum) on Proliferation and Cytokine Expression in Human Peripheral Blood Mononuclear Cells and T-Lymphocytes

  2007cited by this paper
• Solubility studies of oleanolic acid and betulinic acid in aqueous solutions and plant extracts of Viscum album L.

  2007cited by this paper
• Antiproliferative effects of mistletoe (Viscum album L.) extract in urinary bladder carcinoma cell lines.

  2006influential reference
• Anti-Inflammatory and Antinociceptive Activity of Flavonoids Isolated from Viscum album ssp. album

  2006cited by this paper
• AViscum album oligosaccharide activating human natural cytotoxicity is an interferon γ inducer

  2005cited by this paper
• Complete structure determination of the A chain of mistletoe lectin III from Viscum album L. ssp. album

  2004cited by this paper
• Cuticular Waxes and Flavonol Aglycones of Mistletoes

  2003cited by this paper
• Interaction of viscotoxins A3 and B with membrane model systems: implications to their mechanism of action.

  2003cited by this paper
• Mistletoe viscotoxins increase natural killer cell-mediated cytotoxicity.

  2002influential reference
• KM(+), a lectin from Artocarpus integrifolia, induces IL-12 p40 production by macrophages and switches from type 2 to type 1 cell-mediated immunity against Leishmania major antigens, resulting in BALB/c mice resistance to infection.

  2001cited by this paper
• Inhibition of Tumor Growth and Metastasis by Korean Mistletoe Lectin is Associated with Apoptosis and Antiangiogenesis

  2001cited by this paper
• Epicuticular Waxes and Flavonol Aglycones of the European Mistletoe, Viscum album L.

  2000cited by this paper
• Polysaccharides from Fresh Viscum album L. Berry Extract and Their Interaction with Viscum album Agglutinin I

  2000cited by this paper
• Serum levels of IL-12 and the production of IFN-gamma, IL-2 and IL-4 by peripheral blood mononuclear cells (PBMC) in cancer patients treated with Viscum album extract.

  2000cited by this paper
• Toxicity of a standardized mistletoe extract in immunocompromised and healthy individuals.

  1999cited by this paper
• Characterisation of immunological reactivity of patients with adverse effects during therapy with an aqueous mistletoe extract.

  1999cited by this paper
• Pharmacological activity of phenylpropanoids of the mistletoe, Viscum album L., host: Pyrus caucasica Fed.

  1998cited by this paper
• Amino Acid Sequence, S-S Bridge Arrangement and Distribution in Plant Tissues of Thionins from Viscum album

  1997cited by this paper
• Cytotoxicity of Different Viscotoxins and Extracts from the European Subspecies of Viscum album L.

  1996cited by this paper
• Neue Untersuchungen über Flavonoide in Viscum album L. ssp. abietis, album und austriacum

  1993cited by this paper
• Characterization of cytotoxic proteins from mistletoe (Viscum album L.).

  1990cited by this paper
• Effect of a preparation from Viscum album on tumor development in vitro and in mice.

  1990cited by this paper
• Studies on the Constituents of the European Mistletoe, Viscum album L. II

  1987cited by this paper
• [Detection and quantitative determination of lectins and viscotoxins in mistletoe preparations].

  1986cited by this paper
• Recent studies on the anticancer activities of mistletoe (Viscum album) and its alkaloids.

  1986cited by this paper
• Phenylpropanes and lignans of Viscum album cardioactive drugs V.

  1986cited by this paper
• Isolation and properties of three lectins from mistletoe (Viscum album L.).

  1981cited by this paper
• Isolation of biologically active alkaloids from Korean mistletoeViscum album, coloratum

  1980cited by this paper
• Hagers Handbuch der Pharmazeutischen Praxis

  1938influential reference

• Gas and Liquid Chromatography–Mass Spectrometry Investigation of Viscum Album Lipophilic Extracts

  2025cites this paper
• Beyond Viscum album: Mistletoe Physiology and the pharmacological Potential of the Extensive Loranthaceae Family.

  2025cites this paper
• Climate-driven increase in mistletoe infestation in Iberian pine forests

  2025cites this paper
• Integrative therapy in infiltrative lipoma with Viscum album and associations: Case report

  2024influential citation
• A review of selected parasitic plants in Nigeria: converting harms to benefits

  2024cites this paper
• Green Synthesis of Zinc Oxide Nanoparticles Using Viscum album Extracts: Unveiling Bioactive Compounds, Antibacterial Potential, and Antioxidant Activities

  2023cites this paper
• A Review on Mechanistic Insight of Plant Derived Anticancer Bioactive Phytocompounds and Their Structure Activity Relationship

  2022cites this paper
• The future of Viscum album L. in Europe will be shaped by temperature and host availability

  2022cites this paper
• Squamous Cell Carcinoma in a Dog (Canis familiaris) Treated by the Viscum album Therapy – Case Report

  2021cites this paper
• Infestation dynamics of mistletoes in urban and rural landscapes of semi-arid Botswana

  year unknowninfluential citation