Increased glucagon-like peptide-1 secretion may be involved in antidiabetic effects of ginsenosides.

No abstract is available for this paper.

• Publication year

  2013

• Venue

  Journal of Endocrinology

• Publication date

  2013-05-01

• Fields of study

  Medicine, Chemistry

• Identifiers
  DOI 10.1530/JOE-12-0502PMID 23444389
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Enhanced Ca2+ entry, ceramide formation, and apoptotic death of erythrocytes triggered by plumbagin.

  2012cited by this paper
• Calcium entry mediates hyperglycemia-induced apoptosis through Ca2+/calmodulin-dependent kinase ll in retinal capillary endothelial cells

  2012cited by this paper
• Zinc reverses glycine-dependent inactivation of NMDARs in cultured rat hippocampal neurons

  2012cited by this paper
• Liraglutide-associated acute pancreatitis.

  2012cited by this paper
• Pharmacokinetics of verapamil in diabetic rats induced by combination of high-fat diet and streptozotocin injection

  2011cited by this paper
• Pancreatitis, pancreatic, and thyroid cancer with glucagon-like peptide-1-based therapies.

  2011cited by this paper
• Energy Metabolism in Human Pluripotent Stem Cells and Their Differentiated Counterparts

  2011cited by this paper
• Molecular mechanisms underlying nutrient detection by incretin-secreting cells

  2010cited by this paper
• Modulation of glucagon-like peptide-1 release by berberine: in vivo and in vitro studies.

  2010cited by this paper
• Antiobesity and Antihyperglycemic Effects of Ginsenoside Rb1 in Rats

  2010influential reference
• Effect of Endogenous GLP-1 on Insulin Secretion in Type 2 Diabetes

  2010cited by this paper
• Anti-diabetic effects of Panax notoginseng saponins and its major anti-hyperglycemic components.

  2010cited by this paper
• Huang-lian-jie-du-decoction modulates glucagon-like peptide-1 secretion in diabetic rats.

  2009cited by this paper
• Absorption and Disposition of Ginsenosides after Oral Administration of Panax notoginseng Extract to Rats

  2009cited by this paper
• Effect of Panax ginseng supplementation on biomarkers of glucose tolerance, antioxidant status and oxidative stress in type 2 diabetic subjects: results of a placebo‐controlled human intervention trial

  2008cited by this paper
• Incretins: pathophysiological and therapeutic implications of glucose-dependent insulinotropic polypeptide and glucagon-like peptide-1

  2008cited by this paper
• Berberine promotes glucagon-like peptide-1 (7-36) amide secretion in streptozotocin-induced diabetic rats.

  2008cited by this paper
• A role for intestinal endocrine cell-expressed g protein-coupled receptor 119 in glycemic control by enhancing glucagon-like Peptide-1 and glucose-dependent insulinotropic Peptide release.

  2008cited by this paper
• Korean red ginseng (Panax ginseng) improves glucose and insulin regulation in well-controlled, type 2 diabetes: results of a randomized, double-blind, placebo-controlled study of efficacy and safety.

  2008cited by this paper
• Ginsenosides Rb1 and Rg1 Suppress Triglyceride Accumulation in 3T3-L1 Adipocytes and Enhance β-Cell Insulin Secretion and Viability in Min6 Cells via PKA-Dependent Pathways

  2008cited by this paper
• 20(S)-ginsenoside Rg3 enhances glucose-stimulated insulin secretion and activates AMPK.

  2008cited by this paper
• Ginsenoside Rb1 stimulates glucose uptake through insulin-like signaling pathway in 3T3-L1 adipocytes.

  2008cited by this paper
• GLP-1 amplifies insulin signaling by up-regulation of IRβ, IRS-1 and Glut4 in 3T3-L1 adipocytes

  2007cited by this paper
• Biology of incretins: GLP-1 and GIP.

  2007cited by this paper
• Anti-diabetic effects of compound K versus metformin versus compound K-metformin combination therapy in diabetic db/db mice.

  2007cited by this paper
• The physiology of glucagon-like peptide 1.

  2007cited by this paper
• GLP-1 amplifies insulin signaling by up-regulation of IRbeta, IRS-1 and Glut4 in 3T3-L1 adipocytes.

  2007cited by this paper
• Gut-expressed gustducin and taste receptors regulate secretion of glucagon-like peptide-1

  2007cited by this paper
• American Ginseng Stimulates Insulin Production and Prevents Apoptosis through Regulation of Uncoupling Protein-2 in Cultured β Cells

  2006cited by this paper
• Combination of high-fat diet-fed and low-dose streptozotocin-treated rat: a model for type 2 diabetes and pharmacological screening.

  2005cited by this paper
• High performance liquid chromatographic-mass spectrometric determination of ginsenoside Rg3 and its metabolites in rat plasma using solid-phase extraction for pharmacokinetic studies.

  2005influential reference
• Involvement of endogenous glucagon-like peptide-1(7-36) amide on glycaemia-lowering effect of oligofructose in streptozotocin-treated rats.

  2005cited by this paper
• Ginseng and diabetes.

  2005influential reference
• Anti-diabetic effect of ginsenoside Re in ob/ob mice.

  2005influential reference
• Effects of population, age, and cultivation methods on ginsenoside content of wild American ginseng (Panax quinquefolium).

  2005cited by this paper
• Wild ginseng prevents the onset of high-fat diet induced hyperglycemia and obesity in icr mice

  2004cited by this paper
• Application of modified in vitro screening procedure for identifying herbals possessing sulfonylurea-like activity.

  2004cited by this paper
• Development of an HPLC method for determination of metabolic compounds in myocardial tissue.

  2004cited by this paper
• Cell signalling of glucagon-like peptide-1 action in rat skeletal muscle.

  2004cited by this paper
• Effects of Panax ginseng extract on lipid metabolism in humans.

  2003cited by this paper
• A novel glucose-sensing mechanism contributing to glucagon-like peptide-1 secretion from the GLUTag cell line.

  2003cited by this paper
• Determination of polyacetylenes and ginsenosides in Panax species using high performance liquid chromatography.

  2003cited by this paper
• Cell signalling of the GLP-1 action in rat liver.

  2003cited by this paper
• Antidiabetic effects of Panax ginseng berry extract and the identification of an effective component.

  2002cited by this paper
• Possible role of ginsenoside Rb1 on regulation of rat liver triglycerides.

  2002cited by this paper
• Glucose-sensing in glucagon-like peptide-1-secreting cells.

  2002cited by this paper
• A Human Cellular Model for Studying the Regulation of Glucagon-Like Peptide-1 Secretion.

  2001cited by this paper
• American ginseng (Panax quinquefolius L) reduces postprandial glycemia in nondiabetic subjects and subjects with type 2 diabetes mellitus.

  2000cited by this paper
• A new rat model of type 2 diabetes: the fat-fed, streptozotocin-treated rat.

  2000cited by this paper
• Ginseng pharmacology: multiple constituents and multiple actions.

  1999cited by this paper
• Glucose-lowering and insulin-sensitizing actions of exendin-4: studies in obese diabetic (ob/ob, db/db) mice, diabetic fatty Zucker rats, and diabetic rhesus monkeys (Macaca mulatta).

  1999cited by this paper
• Differential Processing of Proglucagon by the Subtilisin-like Prohormone Convertases PC2 and PC3 to Generate either Glucagon or Glucagon-like Peptide (*)

  1995cited by this paper
• Ginseng Therapy in Non-Insulin-Dependent Diabetic Patients: Effects on psychophysical performance, glucose homeostasis, serum lipids, serum aminoterminalpropeptide concentration, and body weight

  1995cited by this paper
• Studies on the mechanism of the hypoglycemic activity of ginsenoside-Rb2 in streptozotocin-diabetic rats.

  1985cited by this paper
• Studies on the absorption, distribution, excretion and metabolism of ginseng saponins. III. The absorption, distribution and excretion of ginsenoside Rb1 in the rat.

  1983cited by this paper
• Studies on the absorption, distribution, excretion and metabolism of ginseng saponins. II. The absorption, distribution and excretion of ginsenoside Rg1 in the rat.

  1983cited by this paper
• Studies on the absorption, distribution, excretion and metabolism of ginseng saponins. IV. Decomposition of ginsenoside-Rg1 and -Rb1 in the digestive tract of rats.

  1983cited by this paper
• Effects of hypoglycemic components in ginseng radix on blood insulin level in alloxan diabetic mice and on insulin release from perfused rat pancreas.

  1981cited by this paper
• Pharmacological sequential trials for the fractionation of components with hypoglycemic activity in alloxan diabetic mice from ginseng radix.

  1981cited by this paper

• Modulation of GLP-1 signalling as an innovative strategy counteracting the onset of heart failure: potential for natural compound supplementation.

  2025cites this paper
• The transcriptomic-based disease network reveals synergistic therapeutic effect of total alkaloids from Coptis chinensis and total ginsenosides from Panax ginseng on type 2 diabetes mellitus.

  2025cites this paper
• The effect of consuming different dietary protein sources at breakfast upon self rated satiety, peptide YY, glucagon like peptide-1, and subsequent food intake in young and older adults

  2025cites this paper
• Anti-obesity and anti-diabetic bioactive peptides: A comprehensive review of their sources, properties, and techno-functional challenges.

  2024cites this paper
• Effects of Ginseng Consumption on Cardiovascular Health Biomarkers in Adults: A Systematic Review and Meta‐Analysis of Randomized Controlled Trials

  2024cites this paper
• Multi-target Compounds against Trypanosomatid Parasites and Mycobacterium tuberculosis.

  2024cites this paper
• Mechanism of Anti-Diabetic Activity from Sweet Potato (Ipomoea batatas): A Systematic Review

  2023cites this paper
• Discovery of new 5-substituted-indole-2-carboxamides as dual epidermal growth factor receptor (EGFR)/cyclin dependent kinase-2 (CDK2) inhibitors with potent antiproliferative action.

  2023cites this paper
• New Dipterocarpol‐Based Molecules with α‐Glucosidase Inhibitory and Hypoglycemic Activity

  2023cites this paper
• Therapeutic application of natural compounds for skeletal muscle-associated metabolic disorders: A review on diabetes perspective.

  2023cites this paper
• Saponins from Camellia sinensis Seeds Stimulate GIP Secretion in Mice and STC-1 Cells via SGLT1 and TGR5

  2022cites this paper
• Synthesis and Biological Evaluation of Indole-2-Carboxamides with Potent Apoptotic Antiproliferative Activity as EGFR/CDK2 Dual Inhibitors

  2022cites this paper
• Boosting GLP-1 by Natural Products.

  2021cites this paper
• Ginsenoside Rb1, salvianolic acid B and their combination modulate gut microbiota and improve glucolipid metabolism in high-fat diet induced obese mice

  2021cites this paper
• Therapeutic potential of ginsenosides on diabetes: From hypoglycemic mechanism to clinical trials

  2020cites this paper
• Kaempferol in ameliorating diabetes-induced fibrosis and renal damage: An in vitro and in vivo study in diabetic nephropathy mice model.

  2020cites this paper
• Ginsenosides for the treatment of metabolic syndrome and cardiovascular diseases: Pharmacology and mechanisms.

  2020cites this paper
• Potential Impact of the Multi-Target Drug Approach in the Treatment of Some Complex Diseases

  2020cites this paper
• DDDT_A_257494 3235..3249

  2020cites this paper
• Targeting Gut Barrier Dysfunction With Phytotherapies: Effective Strategy Against Chronic Diseases.

  2020cites this paper
• Pemberian Ekstrak Biji Jintan Hitam pada Diabetes Melitus Tipe 2 sebagai Terapi

  2019cites this paper
• Effects of Huanglian-Renshen-Decoction, a Fixed Mixture of Traditional Chinese Medicine, on the Improvement of Glucose Metabolism by Maintenance of Pancreatic β Cell Identity in db/db Mice

  2019cites this paper
• Antidiabetic herbal medicines rebranded as dietary supplements

  2019cites this paper
• Atorvastatin Induces Hepatotoxicity in Diabetic Rats via Oxidative Stress, Inflammation, and Anti-Apoptotic Pathway

  2019cites this paper
• Thymoquinone activates imidazoline receptor to enhance glucagon-like peptide-1 secretion in diabetic rats

  2019cites this paper
• Ginseng for the treatment of diabetes and diabetes-related cardiovascular complications: a discussion of the evidence 1.

  2019cites this paper
• Ginsenoside Rb1 as an Anti-Diabetic Agent and Its Underlying Mechanism Analysis

  2019influential citation
• Hyocholic acid species and the risk of type 2 diabetes

  2018cites this paper
• Bridging Type 2 Diabetes and Alzheimer's Disease: Assembling the Puzzle Pieces in the Quest for the Molecules With Therapeutic and Preventive Potential

  2018cites this paper
• Anti‐diabetic potential of peptides: Future prospects as therapeutic agents

  2018cites this paper
• Phytotherapy in the Management of Diabetes: A Review

  2018cites this paper
• Therapeutic Potential of Ginsenosides as an Adjuvant Treatment for Diabetes

  2018cites this paper
• Medicinal Plants with Multiple Effects on Diabetes Mellitus and Its Complications: a Systematic Review

  2018cites this paper
• Glucagon-like Peptide-1: the Old, the New and the Unknown

  2017cites this paper
• A mini-network balance model for evaluating the progression of cardiovascular complications in Goto-Kakizaki rats

  2017cites this paper
• Anti-diabetic effects of natural products an overview of therapeutic strategies

  2017cites this paper
• Phytotherapy in the Management of Diabetes : 2 A Review 3

  2017cites this paper
• Effect of ginseng therapy on diabetes and its chronic complications: lessons learned

  2017cites this paper
• South American herbal extracts reduce food intake through modulation of gastrointestinal hormones in overweight and obese women

  2017cites this paper
• The Effect of Metformin and Ginseng on Alloxan-Induced Diabetic Rats: Hematological, Biochemical and Histopathological Studies

  2017cites this paper
• Diabetes, neurodegenerative diseases, GLP-1 & surgery: evidence calls for exploration

  2017cites this paper
• Ophiopogonin D alleviates high‐fat diet‐induced metabolic syndrome and changes the structure of gut microbiota in mice

  2017cites this paper
• Differential effects of pravastatin on the pharmacokinetics of paroxetine in normal and diabetic rats

  2017cites this paper
• The enhanced atorvastatin hepatotoxicity in diabetic rats was partly attributed to the upregulated hepatic Cyp3a and SLCO1B1

  2016cites this paper
• Photoprotective properties of 20(S)-protopanaxatriol, an aglycone of ginseng saponins: Protection from ultraviolet-B radiation-induced oxidative stress in human epidermal keratinocytes.

  2016cites this paper
• A Review on Role of Plant(s) Extracts and its Phytochemicals for the Management of Diabetes

  2015cites this paper
• Co-administration of paroxetine increased the systemic exposure of pravastatin in diabetic rats due to the decrease in liver distribution

  2015cites this paper
• A review on the medicinal potential of Panax ginseng saponins in diabetes mellitus

  2015cites this paper
• An Essential Role of cAMP Response Element Binding Protein in Ginsenoside Rg1-Mediated Inhibition of Na+/Glucose Cotransporter 1 Gene Expression

  2015cites this paper
• DMD064881 1702..1710

  2015cites this paper
• Combined contribution of increased intestinal permeability and inhibited deglycosylation of ginsenoside Rb1 in intestinal tract to the enhancement of ginsenoside Rb1 exposure in diabetic rats following oral administration

  2015cites this paper
• Effects and molecular mechanisms of the antidiabetic fraction of Acorus calamus L. on GLP-1 expression and secretion in vivo and in vitro.

  2015cites this paper
• Expression of cholecystokinin2-receptor in rat and human L cells and the stimulation of glucagon-like peptide-1 secretion by gastrin treatment.

  2015cites this paper
• Medicinal Plants Qua Glucagon-Like Peptide-1 Secretagogue via Intestinal Nutrient Sensors

  2015cites this paper
• Combined Contribution of Increased Intestinal Permeability and Inhibited Deglycosylation of Ginsenoside Rb1 in the Intestinal Tract to the Enhancement of Ginsenoside Rb1 Exposure in Diabetic Rats after Oral Administration

  2015cites this paper
• High-fat diet enhanced retinal dehydrogenase activity, but suppressed retinol dehydrogenase activity in liver of rats.

  2015cites this paper
• Rational Design of a β‐Glycosidase with High Regiospecificity for Triterpenoid Tailoring

  2015cites this paper
• Association of GLP-1 secretion with anti-hyperlipidemic effect of ginsenosides in high-fat diet fed rats.

  2014influential citation
• Interactions between herbs and antidiabetics: an overview of the mechanisms, evidence, importance, and management

  2014cites this paper
• Co-administration of paroxetine and pravastatin causes deregulation of glucose homeostasis in diabetic rats via enhanced paroxetine exposure

  2014cites this paper
• Methodological and metabolic considerations in the study of caffeine-containing energy drinks.

  2014cites this paper
• Insights into drug discovery from natural medicines using reverse pharmacokinetics.

  2014cites this paper
• Red-Koji Fermented Red Ginseng Ameliorates High Fat Diet-Induced Metabolic Disorders in Mice

  2013cites this paper
• New dammarane-type triterpenoids from the leaves of Panax notoginseng and their protein tyrosine phosphatase 1B inhibitory activity

  2013cites this paper
• 유색보리와 귀리를 이용한 당뇨환자용 즉석죽의 당뇨 개선효과

  2013cites this paper
• Instant Gruel from Colored Barley and Oats for Improving Diabetic Conditions

  2013cites this paper