Ligand Binding Determines Whether CD46 Is Internalized by Clathrin-coated Pits or Macropinocytosis*

No abstract is available for this paper.

• Publication year

  2003

• Venue

  Journal of Biological Chemistry

• Publication date

  2003-11-21

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1074/JBC.M308261200PMID 12958316
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Gene transfection of the HuLy-m2 (Leu-9) antigen into mouse L cells

  2004cited by this paper
• Signals for sorting of transmembrane proteins to endosomes and lysosomes.

  2003cited by this paper
• CD46 in Meningococcal Disease

  2003cited by this paper
• Activation of human CD4+ cells with CD3 and CD46 induces a T-regulatory cell 1 phenotype

  2003cited by this paper
• Microvilli-like structures are associated with the internalization of virulent capsulated Neisseria meningitidis into vascular endothelial cells.

  2002cited by this paper
• CD46 is phosphorylated at tyrosine 354 upon infection of epithelial cells by Neisseria gonorrhoeae

  2002cited by this paper
• A Functional Interaction between CD46 and DLG4

  2002cited by this paper
• Role of Grb2 in EGF-stimulated EGFR internalization.

  2002cited by this paper
• The Cytoplasmic Tail of α1,3-Galactosyltransferase Inhibits Golgi Localization of the Full-length Enzyme*

  2002cited by this paper
• Linking innate and acquired immunity: divergent role of CD46 cytoplasmic domains in T cell–induced inflammation

  2002cited by this paper
• Phosphatidylserine (PS) induces PS receptor–mediated macropinocytosis and promotes clearance of apoptotic cells

  2001cited by this paper
• Antigen Loading of MHC Class I Molecules in the Endocytic Tract

  2001cited by this paper
• Attachment of Neisseria gonorrhoeae to the cellular pilus receptor CD46: identification of domains important for bacterial adherence

  2001cited by this paper
• Mechanism of measles virus-induced suppression of inflammatory immune responses.

  2001cited by this paper
• Endocytosis and signaling. an inseparable partnership.

  2001cited by this paper
• The interface of receptor trafficking and signalling.

  2001cited by this paper
• Endocytosis and Signaling: An Inseparable Partnership

  2001cited by this paper
• Activation of ErbB2 receptor tyrosine kinase supports invasion of endothelial cells by Neisseria meningitidis

  2001cited by this paper
• CD46/CD3 Costimulation Induces Morphological Changes of Human T Cells and Activation of Vav, Rac, and Extracellular Signal-Regulated Kinase Mitogen-Activated Protein Kinase1

  2001cited by this paper
• Interaction of CD46 with measles virus: accessory role of CD46 short consensus repeat IV.

  2000cited by this paper
• Macrophages Present Pinocytosed Exogenous Antigen Via MHC Class I Whereas Antigen Ingested by Receptor-Mediated Endocytosis Is Presented Via MHC Class II

  2000cited by this paper
• Cutting Edge: CD46, a New Costimulatory Molecule for T Cells, That Induces p120CBL and LAT Phosphorylation1

  2000cited by this paper
• Regulation of macropinocytosis by p21-activated kinase-1.

  2000cited by this paper
• Dendritic cells: new roles for Cdc42 and Rac in antigen uptake?

  2000cited by this paper
• Functional Modulation of Human Macrophages Through CD46 (Measles Virus Receptor): Production of IL-12 p40 and Nitric Oxide in Association with Recruitment of Protein-Tyrosine Phosphatase SHP-1 to CD461

  2000cited by this paper
• Human Receptor for Measles Virus (CD46) Enhances Nitric Oxide Production and Restricts Virus Replication in Mouse Macrophages by Modulating Production of Alpha/Beta Interferon

  2000cited by this paper
• Membrane Cofactor Protein (MCP; CD46): Isoform-Specific Tyrosine Phosphorylation1

  2000cited by this paper
• MHC class I-restricted presentation of maleylated protein binding to scavenger receptors.

  1999cited by this paper
• Recycling MHC class I molecules and endosomal peptide loading.

  1999cited by this paper
• Cluster of differentiation antigen 4 (CD4) endocytosis and adaptor complex binding require activation of the CD4 endocytosis signal by serine phosphorylation.

  1999cited by this paper
• Trafficking of the Igα/Igβ Heterodimer with Membrane Ig and Bound Antigen to the Major Histocompatibility Complex Class II Peptide-loading Compartment*

  1999cited by this paper
• Measles Virus Spread by Cell-Cell Contacts: Uncoupling of Contact-Mediated Receptor (CD46) Downregulation from Virus Uptake

  1999cited by this paper
• CD46 is a cellular receptor for human herpesvirus 6.

  1999cited by this paper
• Human CD46 Enhances Nitric Oxide Production in Mouse Macrophages in Response to Measles Virus Infection in the Presence of Gamma Interferon: Dependence on the CD46 Cytoplasmic Domains

  1999cited by this paper
• Importance of the Carboxyl-terminal FTSL Motif of Membrane Cofactor Protein for Basolateral Sorting and Endocytosis

  1999cited by this paper
• Enhanced MHC class II‐restricted presentation of measles virus (MV) hemagglutinin in transgenic mice expressing human MV receptor CD46

  1998cited by this paper
• A Region from the Medium Chain Adaptor Subunit (μ) Recognizes Leucine- and Tyrosine-based Sorting Signals*

  1998cited by this paper
• Lack of p56  lck expression correlates with CD4 endocytosis in primary lymphoid and myeloid cells

  1998cited by this paper
• Membrane cofactor protein (MCP or CD46) is a cellular pilus receptor for pathogenic Neisseria

  1997cited by this paper
• Membrane Cofactor Protein (CD46) Is a Basolateral Protein That Is Not Endocytosed

  1997cited by this paper
• Identification of a cytoplasmic Tyr-X-X-Leu motif essential for down regulation of the human cell receptor CD46 in persistent measles virus infection

  1997cited by this paper
• Human natural killer lymphocytes directly recognize evolutionarily conserved oligosaccharide ligands expressed by xenogeneic tissues.

  1997cited by this paper
• Mechanism of Suppression of Cell-Mediated Immunity by Measles Virus

  1996cited by this paper
• A role for phosphoinositide 3-kinase in the completion of macropinocytosis and phagocytosis by macrophages

  1996cited by this paper
• Identification of two amino acids in the hemagglutinin glycoprotein of measles virus (MV) that govern hemadsorption, HeLa cell fusion, and CD46 downregulation: phenotypic markers that differentiate vaccine and wild-type MV strains

  1996cited by this paper
• Human cell receptor CD46 is down regulated through recognition of a membrane-proximal region of the cytoplasmic domain in persistent measles virus infection

  1996cited by this paper
• Translation is enhanced after silent nucleotide substitutions in A+T- rich sequences of the coding region of CD46 cDNA.

  1996cited by this paper
• Receptor (CD46) modulation and complement-mediated lysis of uninfected cells after contact with measles virus-infected cells

  1996cited by this paper
• The ectodomain of measles virus envelope glycoprotein does not gain access to the cytosol and MHC class I presentation pathway following virus-cell fusion.

  1996cited by this paper
• A Mini-Surge on the Ryder Glacier, Greenland, Observed by Satellite Radar Interferometry

  1996cited by this paper
• The emergence of clathrin-independent pinocytic pathways.

  1995cited by this paper
• Azathioprine induced myelosuppression in renal transplant recipients: A study of 30 patients

  1995cited by this paper
• Formaldehyde inactivation of measles virus abolishes CD46-dependent presentation of nucleoprotein to murine class I-restricted CTLs but not to class II-restricted helper T cells.

  1995cited by this paper
• Cell-to-cell contact via measles virus haemagglutinin-CD46 interaction triggers CD46 downregulation.

  1995cited by this paper
• Membrane cofactor protein (CD46) is a keratinocyte receptor for the M protein of the group A streptococcus.

  1995cited by this paper
• Receptor usage and differential downregulation of CD46 by measles virus wild-type and vaccine strains.

  1995cited by this paper
• The role of the cytoskeleton in renal development.

  1995cited by this paper
• Differential downregulation of CD46 by measles virus strains

  1995cited by this paper
• Measles virus‐induced down‐regulation of CD46 is associated with enhanced sensitivity to complement‐mediated lysis of infected cells

  1995cited by this paper
• Glycosyl-phosphatidylinositol-anchored and transmembrane forms of CD46 display similar measles virus receptor properties: virus binding, fusion, and replication; down-regulation by hemagglutinin; and virus uptake and endocytosis for antigen presentation by major histocompatibility complex class II m

  1994cited by this paper
• Efficient major histocompatibility complex class II-restricted presentation of measles virus relies on hemagglutinin-mediated targeting to its cellular receptor human CD46 expressed by murine B cells

  1994cited by this paper
• Antigen processing and class II MHC peptide-loading compartments in human B-lymphoblastoid cells

  1994cited by this paper
• Efficient MHC Class II‐restricted presentation of measles virus to T cells relies on its targeting to its cellular receptor human CD46 and involves an endosomal pathway

  1994cited by this paper
• The human CD46 molecule is a receptor for measles virus (Edmonston strain).

  1993cited by this paper
• Measles virus haemagglutinin induces down-regulation of gp57/67, a molecule involved in virus binding.

  1993cited by this paper
• Phorbol ester-induced downregulation of CD4 is a multistep process involving dissociation from p56lck, increased association with clathrin- coated pits, and altered endosomal sorting

  1993cited by this paper
• Human membrane cofactor protein (CD46) acts as a cellular receptor for measles virus

  1993cited by this paper
• Measles virus glycoproteins: studies on the structure and interaction of the haemagglutinin and fusion proteins.

  1993cited by this paper
• Tissue‐specific and allelic expression of the complement regulator CD46 is controlled by alternative splicing

  1992cited by this paper
• Membrane cofactor protein (CD46) protects cells from complement- mediated attack by an intrinsic mechanism

  1992cited by this paper
• Mapping of epitopes, glycosylation sites, and complement regulatory domains in human decay accelerating factor.

  1992cited by this paper
• Alternatively spliced RNAs encode several isoforms of CD46 (MCP), a regulator of complement activation

  1991cited by this paper
• Kinase activity controls the sorting of the epidermal growth factor receptor within the multivesicular body.

  1990cited by this paper
• Complement-mediated tumor cell damage induced by antibodies against membrane cofactor protein (MCP, CD46)

  1990cited by this paper
• The human cell-surface glycoproteins HuLy-m5, membrane co-factor protein (MCP) of the complement system, and trophoblast leucocyte-common (TLX) antigen, are CD46.

  1990cited by this paper
• Evaluation of the human sperm acrosome reaction using a monoclonal antibody, GB24, and fluorescence-activated cell sorter.

  1989cited by this paper
• Segregation of transferrin to a mildly acidic (pH 6.5) para-Golgi compartment in the recycling pathway.

  1984cited by this paper
• Hu Ly-m5: a unique antigen physically associated with HLA molecules.

  1983cited by this paper

• Complementing Anticancer Therapy: Antibody-Drug Conjugates Targeting CD46 as Prostate Cancer Treatment.

  2025cites this paper
• CD46 and CD59 inhibitors enhance complement-dependent cytotoxicity of anti-CD38 monoclonal antibodies daratumumab and isatuximab in multiple myeloma and other B-cell malignancy cells

  2024cites this paper
• Cell surface protein aggregation triggers endocytosis to maintain plasma membrane proteostasis

  2023cites this paper
• A Human In Vitro Model to Study Adenoviral Receptors and Virus Cell Interactions

  2022cites this paper
• Adenovirus and the Cornea: More Than Meets the Eye

  2021cites this paper
• The Revolving Door of Adenovirus Cell Entry: Not All Pathways Are Equal

  2021cites this paper
• Anti-disialoganglioside antibody internalization by neuroblastoma cells as a mechanism of immunotherapy resistance

  2021cites this paper
• Primary differentiated respiratory epithelial cells respond to apical measles virus infection by shedding multinucleated giant cells

  2021cites this paper
• Real Time Analysis of Bovine Viral Diarrhea Virus (BVDV) Infection and Its Dependence on Bovine CD46

  2020cites this paper
• Activation of cGAS/STING pathway upon paramyxovirus infection

  2020cites this paper
• CD46 and Oncologic Interactions: Friendly Fire against Cancer

  2020cites this paper
• Measles Encephalitis: Towards New Therapeutics

  2019cites this paper
• Fluorophore labelled BVDV: a novel tool for the analysis of infection dynamics

  2019cites this paper
• Biological evaluation of an L-dideoxy bicyclic nucleoside analogue active against measles virus

  2019influential citation
• Targeting CD46 for both adenocarcinoma and neuroendocrine prostate cancer.

  2018cites this paper
• SLAMF1/CD150: a universal receptor for morbilliviruses

  2017cites this paper
• Autophagy in Measles Virus Infection

  2017cites this paper
• The Measles Virus Receptor SLAMF1 Can Mediate Particle Endocytosis

  2017influential citation
• Measles Virus Enters Breast and Colon Cancer Cell Lines through a PVRL4-Mediated Macropinocytosis Pathway

  2017cites this paper
• Preclinical safety, pharmacokinetics, pharmacodynamics, and biodistribution studies with Ad35K++ protein: a novel rituximab cotherapeutic

  2016cites this paper
• Preclinical safety, pharmacokinetics, pharmacodynamics and biodistribution studies with Ad35K++ protein, a novel rituximab co‐therapeutic in mice and non‐human primates.

  2016cites this paper
• Macrophage programming and host responses to bacterial infection

  2016cites this paper
• Macropinocytosis Exploitation by Cancers and Cancer Therapeutics

  2016cites this paper
• Non-random pairing of CD46 isoforms with skewing towards BC2 and C2 in activated and memory/effector T cells

  2016cites this paper
• Biology of Adenovirus Cell Entry: Receptors, Pathways, Mechanisms

  2016cites this paper
• Anticorps anti-cd46 humains formant des macropinosomes et agents thérapeutiques anti-cancéreux ciblés

  2015cites this paper
• Title Crosslinking-induced endocytosis of acetylcholine receptors byquantum dots

  2014cites this paper
• GP96 Interacts with HHV-6 during Viral Entry and Directs It for Cellular Degradation

  2014cites this paper
• Crosslinking-Induced Endocytosis of Acetylcholine Receptors by Quantum Dots

  2014cites this paper
• Adenovirus signalling in entry

  2013cites this paper
• The role of complement in CD4⁺ T cell homeostasis and effector functions.

  2013cites this paper
• CD46: the 'multitasker' of complement proteins.

  2013cites this paper
• syndrome syndrome (aHUS), fatal Stx-HUS, C3 glomerulonephritis, and the HELLP Membrane cofactor protein mutations in atypical hemolytic uremic

  2013cites this paper
• Die Rolle regulatorischer T-Zellen bei der Masernviruspathogenese

  2012cites this paper
• Adenovirus Species B interactions with CD46

  2012cites this paper
• CD46 Measles Virus Receptor Polymorphisms Influence Receptor Protein Expression and Primary Measles Vaccine Responses in Naive Australian Children

  2012cites this paper
• CD46 processing: a means of expression.

  2012cites this paper
• Henipavirus receptor usage and tropism.

  2012cites this paper
• Attenuation of CD4+ T-cell function by human adenovirus type 35 is mediated by the knob protein.

  2012cites this paper
• The Dynamic Processing of CD46 Intracellular Domains Provides a Molecular Rheostat for T Cell Activation

  2011cites this paper
• Avidity Binding of Human Adenovirus Serotypes 3 and 7 to the Membrane Cofactor CD46 Triggers Infection

  2011cites this paper
• A Novel Role for CD46 in Wound Repair

  2011cites this paper
• An adenovirus traffic update: from receptor engagement to the nuclear pore.

  2011cites this paper
• Adenovirus type-35 vectors block human CD4+ T-cell activation via CD46 ligation

  2011cites this paper
• Virus-Induced Encephalitis and Innate Immune Responses – A Focus on Emerging or Re-Emerging Viruses

  2011cites this paper
• Replication-competent adenovirus 11p vector as a new oncolytic agent

  2011cites this paper
• The Reorientation of T-Cell Polarity and Inhibition of Immunological Synapse Formation by CD46 Involves Its Recruitment to Lipid Rafts

  2011cites this paper
• CD46 Plasticity and Its Inflammatory Bias in Multiple Sclerosis

  2011cites this paper
• Measles Virus Glycoprotein-Pseudotyped Lentiviral Vector-Mediated Gene Transfer into Quiescent Lymphocytes Requires Binding to both SLAM and CD46 Entry Receptors

  2011cites this paper
• REGULATION OF HUMAN DENDRITIC CELLS AND T CELLS BY ADENOVIRUS VECTORS TYPES 5 AND 35: IMPLICATIONS FOR VACCINE DESIGN

  2011cites this paper
• Unity and diversity in the human adenoviruses: exploiting alternative entry pathways for gene therapy.

  2010cites this paper
• Cellular receptors, differentiation and endocytosis requirements are key factors for type I IFN response by human epithelial, conventional and plasmacytoid dendritic infected cells by measles virus.

  2010cites this paper
• New insights into measles virus propagation: from entry to shedding

  2010cites this paper
• Macropinocytotic Uptake and Infection of Human Epithelial Cells with Species B2 Adenovirus Type 35

  2010cites this paper
• Mechanism of Neuroinflammation: Enhanced Cytotoxicity and IL-17 Production via CD46 Binding

  2010cites this paper
• Adenovirus 11p downregulates CD46 early in infection.

  2010cites this paper
• Human adenoviruses : new bioassays for antiviral screening and CD46 interaction

  2010cites this paper
• Autophagy induction by the pathogen receptor CD46.

  2009cites this paper
• Regulator of complement activation (RCA) gene cluster in Xenopus tropicalis

  2009cites this paper
• Nipah virus entry can occur by macropinocytosis.

  2009cites this paper
• Presenilin/γ-Secretase Cleaves CD46 in Response to Neisseria Infection

  2009cites this paper
• A method for prolonged imaging of motile lymphocytes

  2009cites this paper
• Measles virus and CD46.

  2009cites this paper
• Mise en évidence de l'entrée cellulaire du virus Nipah par macropinocytose : bases moléculaires et inhibition

  2009cites this paper
• Subversion of CtBP1‐controlled macropinocytosis by human adenovirus serotype 3

  2008influential citation
• Uncommon Endocytic and Trafficking Pathway of the Natural Killer Cell CD94/NKG2A Inhibitory Receptor

  2008cites this paper
• Membrane cofactor protein mutations in atypical hemolytic uremic syndrome (aHUS), fatal Stx-HUS, C3 glomerulonephritis, and the HELLP syndrome.

  2007cites this paper
• Membrane cofactor protein (MCP, CD46) binding to clinical isolates of Streptococcus pyogenes: binding to M type 18 strains is independent of Emm or Enn proteins.

  2007cites this paper
• Cellular receptors for species B adenoviruses

  2007cites this paper
• The many effects of complement C3- and C5-binding proteins in renal injury.

  2007cites this paper
• Preferential Activation of Toll-Like Receptor Nine by CD46-Utilizing Adenoviruses

  2006cites this paper
• A novel assay for monitoring internalization of nanocarrier coupled antibodies

  2006cites this paper
• Ligation of the cell surface receptor, CD46, alters T cell polarity and response to antigen presentation

  2006cites this paper
• The complement inhibitor, CRIT, undergoes clathrin-dependent endocytosis.

  2005cites this paper
• Emerging roles and new functions of CD46

  2005influential citation
• Measles virus superinfection immunity and receptor redistribution in persistently infected NT2 cells.

  2005cites this paper
• Release of host‐derived membrane vesicles following pilus‐mediated adhesion of Neisseria gonorrhoeae

  2005cites this paper
• The nucleotide sequence and a first generation gene transfer vector of species B human adenovirus serotype 3

  2005cites this paper
• A network of PDZ-containing proteins regulates T cell polarity and morphology during migration and immunological synapse formation.

  2005cites this paper
• Adenovirus species B: receptors, tropism and hematopoietic cells

  2004influential citation
• Cell signals transduced by complement.

  2004cites this paper
• CD46: a complement regulator and pathogen receptor that mediates links between innate and acquired immune function.

  2004cites this paper
• CD46: expanding beyond complement regulation.

  2004cites this paper
• Bovine viral diarrhoea virus is internalized by clathrin-dependent receptor-mediated endocytosis.

  2004cites this paper