Skin and oral intervention for food allergy prevention based on dual allergen exposure hypothesis

Early-onset atopic dermatitis increases an individual’s risk of food allergies, suggesting that transcutaneous sensitization may occur through inflamed skin. Regarding food allergy causation, the dual allergen exposure hypothesis proposes that oral allergen exposure leads to immune tolerance, whereas allergen exposure via inflamed skin causes food allergies. This hypothesis suggests that it is important to induce oral immune tolerance and prevent allergic food sensitization through the skin. This review focuses on the breakthrough evidence based on the dual allergen exposure hypothesis that involves both skin and oral interventions for food allergy prevention.

• Publication year

  2023

• Venue

  Clinical and experimental pediatrics

• Publication date

  2023-06-14

• Fields of study

  Medicine, Environmental Science

• Identifiers
  DOI 10.3345/cep.2023.00045PMID 37321587PMCID 11471915
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

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