Effect of R77Q, R77A and R80A changes in Vpr on HIV-1 replication and CD4 T cell depletion in human lymphoid tissue ex vivo

No abstract is available for this paper.

• Publication year

  2006

• Venue

  AIDS (London)

• Publication date

  2006-04-04

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1097/01.aids.0000218546.31716.7fPMID 16549966
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• The role of upstream U3 sequences in HIV-1 replication and CD4+ T cell depletion in human lymphoid tissue ex vivo.

  2005cited by this paper
• Human Immunodeficiency Virus Type 1 Inhibits DNA Damage-Triggered Apoptosis by a Nef-Independent Mechanism

  2005cited by this paper
• Human immunodeficiency virus type 1 (HIV-1) Vpr-regulated cell death: insights into mechanism

  2005cited by this paper
• Is the Vpr R77Q mutation associated with long-term non-progression of HIV infection?

  2004cited by this paper
• Vpr and Vpu Are Important for Efficient Human Immunodeficiency Virus Type 1 Replication and CD4+ T-Cell Depletion in Human Lymphoid Tissue Ex Vivo

  2004cited by this paper
• Vpr R77Q is associated with long-term nonprogressive HIV infection and impaired induction of apoptosis.

  2003influential reference
• The mitochondriotoxic domain of Vpr determines HIV-1 virulence.

  2003influential reference
• Hemofiltrate CC Chemokine 1[9-74] Causes Effective Internalization of CCR5 and Is a Potent Inhibitor of R5-Tropic Human Immunodeficiency Virus Type 1 Strains in Primary T Cells and Macrophages

  2002cited by this paper
• Nef Enhances Human Immunodeficiency Virus Type 1 Infectivity and Replication Independently of Viral Coreceptor Tropism

  2002cited by this paper
• Evidence for a cytopathogenicity determinant in HIV-1 Vpr

  2002cited by this paper
• HIV-1 Vpr Enhances Viral Burden by Facilitating Infection of Tissue Macrophages but Not Nondividing CD4+ T Cells

  2001cited by this paper
• Functional and Structural Characterization of Synthetic HIV-1 Vpr That Transduces Cells, Localizes to the Nucleus, and Induces G2 Cell Cycle Arrest*

  2000cited by this paper
• The HIV-1 Viral Protein R Induces Apoptosis via a Direct Effect on the Mitochondrial Permeability Transition Pore

  2000cited by this paper
• Nef Enhances Human Immunodeficiency Virus Replication and Responsiveness to Interleukin-2 in Human Lymphoid Tissue Ex Vivo

  1999influential reference
• Preferential coreceptor utilization and cytopathicity by dual-tropic HIV-1 in human lymphoid tissue ex vivo.

  1999cited by this paper
• CCR5- and CXCR4-tropic HIV-1 are equally cytopathic for their T-cell targets in human lymphoid tissue

  1999cited by this paper
• HIV-1 Vpr increases viral expression by manipulation of the cell cycle: A mechanism for selection of Vpr in vivo

  1998cited by this paper
• Viral protein R regulates nuclear import of the HIV‐1 pre‐integration complex

  1998cited by this paper
• Adaptation to promiscuous usage of CC and CXC‐chemokine coreceptors in vivo correlates with HIV‐1 disease progression

  1998cited by this paper
• Vpr Stimulates Viral Expression and Induces Cell Killing in Human Immunodeficiency Virus Type 1-Infected Dividing Jurkat T Cells

  1998cited by this paper
• Evolution of Syncytium-Inducing and Non-Syncytium-Inducing Biological Virus Clones in Relation to Replication Kinetics during the Course of Human Immunodeficiency Virus Type 1 Infection

  1998cited by this paper
• Genetic Characterization ofvif, vpr,andvpuSequences from Long-Term Survivors of Human Immunodeficiency Virus Type 1 Infection

  1997cited by this paper
• Genetic characterization of vif, vpr, and vpu sequences from long-term survivors of human immunodeficiency virus type 1 infection.

  1997cited by this paper
• Human immunodeficiency virus type 1 Vpr arrests the cell cycle in G2 by inhibiting the activation of p34cdc2-cyclin B

  1995cited by this paper
• Vpr is required for efficient replication of human immunodeficiency virus type-1 in mononuclear phagocytes.

  1995cited by this paper
• Infection of human tonsil histocultures: A model for HIV pathogenesis

  1995cited by this paper
• Active nuclear import of human immunodeficiency virus type 1 preintegration complexes.

  1992cited by this paper

• HIV-1 Vpr induces an NFAT-controlled transcriptional program in primary CD4+ T cells

  2026cites this paper
• Variation in HIV-1 Tat and Vpr protein amino acid sequences and its association with vascular health measures in a South African cohort: an exploratory study

  2025cites this paper
• Identification of polymorphisms associated with attenuation of Vif and Vpr in HIV-1 Elite Controllers

  2025cites this paper
• HIV-1 Vpr Functions in Primary CD4+ T Cells

  2024cites this paper
• The influence of viral protein R amino acid substitutions on clinical outcomes in people living with HIV: A systematic review

  2022cites this paper
• HIV-1 Subtype C Vpr Amino Acid Residue 45Y and Specific Conserved Fragments Are Associated with Neurocognitive Impairment and Markers of Viral Load

  2022cites this paper
• Vpr Targets TET2 for Degradation by CRL4VprBP E3 Ligase to Sustain IL-6 Expression and Enhance HIV-1 Replication.

  2018cites this paper
• Edinburgh Research Explorer Generation of infectious molecular clones of simian immunodeficiency virus from fecal consensus sequences of wild chimpanzees sequences

  2018cites this paper
• Dual role of the chromatin-binding factor PHF13 in the pre- and post-integration phases of HIV-1 replication

  2017cites this paper
• Yeast for virus research

  2017cites this paper
• Virion encapsidated HIV-1 Vpr induces NFAT to prime non-activated T cells for productive infection

  2016influential citation
• Caracterização de variantes virais de HIV-1 em indivíduos soropositivos com perfil de controle da progressão para a AIDS e da replicação viralavaliação da ocorrência de variantes de escape da resposta imune

  2016cites this paper
• Copyright © 201 R ( Vpr ) mutations : associated evance for clinical pathologies

  2016cites this paper
• HIV1‐viral protein R (Vpr) mutations: associated phenotypes and relevance for clinical pathologies

  2016cites this paper
• Vpr Enhances Tumor Necrosis Factor Production by HIV-1-Infected T Cells

  2015influential citation
• R77Q and Q3R HIV1-VPR mutations in an otherwise asymptomatic 5-year-old child with repeated ear infections

  2014cites this paper
• Case Report R77Q and Q3R HIV1-VPR mutations in an otherwise asymptomatic 5-year-old child with repeated ear infections

  2014cites this paper
• Two Highly Variable Vpr 84 and Vpr 85 Residues within the HIV-1-Vpr C-Terminal Protein Transduction Domain Control Transductionnal Activity and Define a Clade Specific Polymorphism

  2014cites this paper
• How HIV-1 Nef hijacks the AP-2 clathrin adaptor to downregulate CD4

  2014cites this paper
• Vpr expression abolishes the capacity of HIV-1 infected cells to repair uracilated DNA

  2013cites this paper
• Viral Factors in Non-Progression

  2013cites this paper
• Modulation of NKG2D-Mediated Cytotoxic Functions of Natural Killer Cells by Viral Protein R from HIV-1 Primary Isolates

  2011cites this paper
• The Host-Pathogen interaction of human cyclophilin A and HIV-1 Vpr requires specific N-terminal and novel C-terminal domains

  2011cites this paper
• Interactions between human immunodeficiency virus (HIV)-1 Vpr expression and innate immunity influence neurovirulence

  2011cites this paper
• Association entre les dérégulations des cellules dendritiques et les altérations des lymphocytes B présentes chez les patients infectés par le VIH

  2011cites this paper
• Mechanisms of HIV-associated lymphocyte apoptosis: 2010

  2010cites this paper
• Protein Kinase A Phosphorylation Activates Vpr-Induced Cell Cycle Arrest during Human Immunodeficiency Virus Type 1 Infection

  2010cites this paper
• Manipulation of the ubiquitin-proteasome system by HIV-1 : role of the accessory protein Vpr

  2010cites this paper
• Structure-function relationship of Vpr: biological implications.

  2009cites this paper
• In vitro dynamics of HIV-1 BF intersubtype recombinants genomic regions involved in the regulation of gene expression

  2009cites this paper
• Viral Genetic Determinants of Nonprogressive HIV Type 1 Subtype C Infection in Antiretroviral Drug-Naive Children

  2009cites this paper
• Characterization of the Molecular Determinants of Primary HIV-1 Vpr Proteins: Impact of the Q65R and R77Q Substitutions on Vpr Functions

  2009cites this paper
• CHARACTERIZATION OF VIRUS HOST-INTERACTIONS THAT REGULATE HIV-1 REPLICATION

  2009cites this paper
• VIRAL GENETIC DETERMINANTS OF NON PROGRESSIVE HIV-1 SUBTYPE C INFECTION IN ANTIRETROVIRAL DRUG NAÏVE CHILDREN

  2009cites this paper
• Molecular Characterization of the HIV Type 1 vpr Gene in Infected Chinese Former Blood/Plasma Donors at Different Stages of Diseases

  2008cites this paper
• HIV-1 Vpr: mechanisms of G2 arrest and apoptosis.

  2008cites this paper
• Vpr Cytopathicity Independent of G2/M Cell Cycle Arrest in Human Immunodeficiency Virus Type 1-Infected CD4+ T Cells

  2007cites this paper
• Molecular Characterization of the HIV Type 1 Subtype C Accessory Genes vif, vpr, and vpu

  2007cites this paper
• HIV-1-infected long-term non-progressors have milder mitochondrial impairment and lower mitochondrially-driven apoptosis in peripheral blood mononuclear cells than typical progressors.

  2007cites this paper
• Antagonistic interaction of HIV-1 Vpr with Hsf-mediated cellular heat shock response and Hsp16 in fission yeast (Schizosaccharomyces pombe)

  2007cites this paper
• Proline 35 of Human Immunodeficiency Virus Type 1 (HIV-1) Vpr Regulates the Integrity of the N-Terminal Helix and the Incorporation of Vpr into Virus Particles and Supports the Replication of R5-Tropic HIV-1 in Human Lymphoid Tissue Ex Vivo

  2007cites this paper
• Vpr Cytopathicity Independent of G 2 /M Cell Cycle Arrest in Human Immunodeficiency Virus Type 1-Infected CD4 (cid:1) T Cells (cid:1)

  2007cites this paper
• Generation of Infectious Molecular Clones of Simian Immunodeficiency Virus from Fecal Consensus Sequences of Wild Chimpanzees

  2007cites this paper
• Cell-based chemical genetic screen identifies damnacanthal as an inhibitor of HIV-1 Vpr induced cell death.

  2006cites this paper
• HIV-1 Vpr-Induced Apoptosis Is Cell Cycle Dependent and Requires Bax but Not ANT

  2006influential citation
• It’s All in the Interaction: Quantitating Gene Networks

  2004cites this paper
• Identification of potential HIV restriction factors by combining evolutionary signatures with functional analyses

  year unknowncites this paper