Role of artesunate in autoimmune diseases and signaling pathways.

Artesunate (ART) is a derivative of artemisinin. Compared with artemisinin, ART has excellent water solubility, high stability and oral bioavailability. In this review, the application of ART in classic autoimmune diseases such as rheumatoid arthritis, systemic lupus erythematosus and ulcerative colitis is summarized. ART exhibited similar or even better efficacy than other highly effective immunosuppressive agents, such as methotrexate and cyclophosphamide. In addition, ART exerts its pharmacological effects mainly by inhibiting the production of inflammatory factors, reactive oxygen species, autoantibodies and the migration of cells to reduce damage to tissues or organs. Moreover, ART widely affected the NF-κB, PI3K/Akt, JAK/STAT and MAPK pathways to exert pharmacological effects.

• Publication year

  2023

• Venue

  Immunotherapy

• Publication date

  2023-07-11

• Fields of study

  Medicine

• Identifiers
  DOI 10.2217/imt-2023-0052PMID 37431601
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Artesunate Protects Pancreatic β-Cells From Streptozotocin-Induced Diabetes via Inhibition of the NLRP3/Caspase-1/GSDMD Pathway.

  2022cited by this paper
• An ROS-responsive artesunate prodrug nanosystem co-delivers dexamethasone for rheumatoid arthritis treatment through the HIF-1α/NF-κB cascade regulation of ROS scavenging and macrophage repolarization.

  2022cited by this paper
• Artesunate suppresses Th17 response via inhibiting IRF4-mediated glycolysis and ameliorates Sjog̈ren’s syndrome

  2022cited by this paper
• Circulating microRNAs in Medicine

  2022cited by this paper
• Advanced Glycation End Products and Diabetes Mellitus: Mechanisms and Perspectives

  2022cited by this paper
• Artesunate alleviates the inflammatory response of ulcerative colitis by regulating the expression of miR-155

  2021cited by this paper
• Role of Artesunate on cardiovascular complications in rats with type 1 diabetes mellitus

  2021cited by this paper
• Artesunate Combined With Metformin Ameliorate on Diabetes-Induced Xerostomia by Mitigating Superior Salivatory Nucleus and Salivary Glands Injury in Type 2 Diabetic Rats via the PI3K/AKT Pathway

  2021cited by this paper
• Pathogenesis of Autoimmune Hepatitis—Cellular and Molecular Mechanisms

  2021cited by this paper
• MCP-1: Function, regulation, and involvement in disease

  2021cited by this paper
• The IL23-IL17 Immune Axis in the Treatment of Ulcerative Colitis: Successes, Defeats, and Ongoing Challenges

  2021cited by this paper
• 9,10-Anhydrodehydroartemisinin Attenuates Experimental Autoimmune Encephalomyelitis by Inhibiting Th1 and Th17 Cell Differentiation

  2021cited by this paper
• Artesunate attenuates bone erosion in rheumatoid arthritis by suppressing reactive oxygen species via activating p62/Nrf2 signaling.

  2021cited by this paper
• Relevance of the Pyroptosis-Related Inflammasome Pathway in the Pathogenesis of Diabetic Kidney Disease

  2021cited by this paper
• Artesunate ameliorates DSS-induced ulcerative colitis by protecting intestinal barrier and inhibiting inflammatory response

  2020cited by this paper
• Type I interferon in the pathogenesis of systemic lupus erythematosus.

  2020cited by this paper
• CD4 T Helper Cell Subsets and Related Human Immunological Disorders

  2020cited by this paper
• An updated advance of autoantibodies in autoimmune diseases.

  2020cited by this paper
• Recent updates on the management of autoimmune hepatitis

  2020cited by this paper
• Deleterious effects of malaria in pregnancy on the developing fetus: a review on prevention and treatment with antimalarial drugs.

  2020cited by this paper
• Target verification of artesunate-related antiviral drugs: assessing the role of mitochondrial and regulatory proteins by click chemistry and fluorescence labeling.

  2020cited by this paper
• Salivary gland epithelial cells from patients with Sjögren’s syndrome induce B-lymphocyte survival and activation

  2020cited by this paper
• Artesunate inhibits Sjögren's syndrome-like autoimmune responses and BAFF-induced B cell hyperactivation via TRAF6-mediated NF-κB signaling.

  2020cited by this paper
• Genetics and epigenetics of ibd.

  2020cited by this paper
• The remission phase in type 1 diabetes: Changing epidemiology, definitions, and emerging immuno‐metabolic mechanisms

  2020cited by this paper
• Artemisinin inhibits the replication of flaviviruses by promoting the type I interferon production.

  2020cited by this paper
• Therapeutic effects of artesunate on lupus-prone MRL/lpr mice are dependent on T follicular helper cell differentiation and activation of JAK2-STAT3 signaling pathway.

  2019cited by this paper
• Unexpected mechanism of colitis amelioration by artesunate, a natural product from Artemisia annua L.

  2019cited by this paper
• Secondary thrombotic microangiopathy in systemic lupus erythematosus and antiphospholipid syndrome, the role of complement and use of eculizumab: Case series and review of literature.

  2019cited by this paper
• Artesunate prevents type 1 diabetes in NOD mice mainly by inducing protective IL‐4—producing T cells and regulatory T cells

  2019cited by this paper
• Artemisinin compounds sensitize cancer cells to ferroptosis by regulating iron homeostasis

  2019cited by this paper
• A novel function of artesunate on inhibiting migration and invasion of fibroblast-like synoviocytes from rheumatoid arthritis patients

  2019cited by this paper
• Macrophage migration inhibitory factor (MIF) as a therapeutic target for rheumatoid arthritis and systemic lupus erythematosus

  2019cited by this paper
• The heterogeneous pathogenesis of type 1 diabetes mellitus

  2019cited by this paper
• Sensitivity and Specificity of Pathologic Findings to Diagnose Lupus Nephritis.

  2019cited by this paper
• Artesunate ameliorates high glucose-induced rat glomerular mesangial cell injury by suppressing the TLR4/NF-κB/NLRP3 inflammasome pathway.

  2018cited by this paper
• Clinical and immunological parameters of Sjögren's syndrome.

  2018cited by this paper
• The Dendritic Cell Strikes Back.

  2018cited by this paper
• From patients with arthralgia, pre-RA and recently diagnosed RA: what is the current status of understanding RA pathogenesis?

  2018cited by this paper
• Pancreatic Beta Cell Death: Novel Potential Mechanisms in Diabetes Therapy

  2018cited by this paper
• Multiple sclerosis: clinical aspects

  2018cited by this paper
• B cells in the pathogenesis of primary Sjögren syndrome

  2018cited by this paper
• Inhibition of TRAF6 ubiquitin-ligase activity by PRDX1 leads to inhibition of NFKB activation and autophagy activation

  2018cited by this paper
• JAK–STAT Signaling as a Target for Inflammatory and Autoimmune Diseases: Current and Future Prospects

  2017cited by this paper
• Artesunate to treat severe malaria in travellers: review of efficacy and safety and practical implications

  2017cited by this paper
• Type 1 diabetes mellitus

  2017cited by this paper
• Artesunate inhibits type I interferon-induced production of macrophage migration inhibitory factor in patients with systemic lupus erythematosus

  2017cited by this paper
• The worldwide incidence and prevalence of systemic lupus erythematosus: a systematic review of epidemiological studies

  2017cited by this paper
• Mechanisms and New Strategies for Primary Sjögren's Syndrome.

  2017cited by this paper
• Antimalarial agent artesunate protects Concanavalin A-induced autoimmune hepatitis in mice by inhibiting inflammatory responses.

  2017cited by this paper
• From ancient herb to modern drug: Artemisia annua and artemisinin for cancer therapy.

  2017cited by this paper
• Artesunate Ameliorates Experimental Autoimmune Encephalomyelitis by Inhibiting Leukocyte Migration to the Central Nervous System

  2016cited by this paper
• Progressive multiple sclerosis: from pathogenic mechanisms to treatment.

  2016cited by this paper
• Nrf2 inhibition reverses the resistance of cisplatin-resistant head and neck cancer cells to artesunate-induced ferroptosis

  2016cited by this paper
• In autoimmune hepatitis type 1 or the autoimmune hepatitis–sclerosing cholangitis variant defective regulatory T‐cell responsiveness to IL‐2 results in low IL‐10 production and impaired suppression

  2015cited by this paper
• A genetic study on C5-TRAF1 and progression of joint damage in rheumatoid arthritis

  2015cited by this paper
• Hydroxychloroquine as an anti-thrombotic in antiphospholipid syndrome.

  2015cited by this paper
• Human autoimmune diseases: a comprehensive update

  2015cited by this paper
• Immunopathology of multiple sclerosis

  2015cited by this paper
• Continuously elevated serum matrix metalloproteinase-3 for 3 ~ 6 months predict one-year radiographic progression in rheumatoid arthritis: a prospective cohort study

  2015cited by this paper
• Environmental risk factors and multiple sclerosis: an umbrella review of systematic reviews and meta-analyses.

  2015cited by this paper
• Epidemiology of primary Sjögren's syndrome: a systematic review and meta-analysis

  2014cited by this paper
• CDX-2, MUC-2 and B-catenin as intestinal markers in pure mucinous carcinoma of the breast

  2014cited by this paper
• Breach of Tolerance: Primary Biliary Cirrhosis

  2014cited by this paper
• Claudin-1 regulates intestinal epithelial homeostasis through the modulation of Notch-signalling

  2013cited by this paper
• Artemisinin Analogue SM934 Ameliorates Murine Experimental Autoimmune Encephalomyelitis through Enhancing the Expansion and Functions of Regulatory T Cell

  2013cited by this paper
• Inhibitory effect of the antimalarial agent artesunate on collagen-induced arthritis in rats through nuclear factor kappa B and mitogen-activated protein kinase signaling pathway.

  2013cited by this paper
• Oxidative stress as a potential biomarker for determining disease activity in patients with Rheumatoid Arthritis

  2012cited by this paper
• Artesunate versus quinine for treating severe malaria.

  2012cited by this paper
• Replication of Crohn's disease-associated AIEC within macrophages is dependent on TNF-α secretion

  2012cited by this paper
• Genotoxicity assessment of the antimalarial compound artesunate in somatic cells of mice.

  2011cited by this paper
• In vitro evaluation of the genotoxic and cytotoxic effects of artesunate, an antimalarial drug, in human lymphocytes

  2011cited by this paper
• Hydroxychloroquine in SLE: old drug, new perspectives

  2010cited by this paper
• Pharmacokinetics, tissue distribution and mass balance of radiolabeled dihydroartemisinin in male rats

  2009cited by this paper
• A Pilot Study of the Therapeutic Efficacy and Mechanism of Artesunate in the MRL/lpr Murine Model of Systemic Lupus Erythematosus

  2009cited by this paper
• Absence of time-dependent artesunate pharmacokinetics in healthy subjects during 5-day oral administration

  2008cited by this paper
• Differential effects on angiogenesis of two antimalarial compounds, dihydroartemisinin and artemisone: implications for embryotoxicity.

  2007cited by this paper
• Epidemiology of autoimmune diseases in Denmark.

  2007cited by this paper
• Artemisinin derivatives: toxic for laboratory animals, safe for humans?

  2004cited by this paper
• Artemisinin: mechanisms of action, resistance and toxicity.

  2002cited by this paper
• Glucuronidation of dihydroartemisinin in vivo and by human liver microsomes and expressed UDP-glucuronosyltransferases.

  2002cited by this paper
• Thioredoxin as a biomarker for oxidative stress in patients with rheumatoid arthritis.

  2002cited by this paper
• Systemic Lupus Erythematosus

  1991cited by this paper

• Artesunate ameliorates experimental autoimmune uveitis by inhibiting the LCN2-STAT3 axis and suppressing microglial activation

  2026cites this paper
• From malaria fighter to diabetes guardian: the emerging role of artesunate in treating diabetes and diabetic complications

  2025cites this paper
• Artesunate alleviates cerebral ischemia/reperfusion injury by suppressing FUNDC1-mediated excessive mitophagy.

  2025cites this paper
• Dyslipidemia in Myasthenia Gravis: A Systematic Review and Meta-Analysis

  2025cites this paper
• Artesunate Ameliorates SLE Atherosclerosis Through PPARγ-Driven Cholesterol Efflux Restoration and Disruption of Lipid Raft-Organized TLR9/MyD88 Signaling Pathway

  2025cites this paper
• Artesunate inhibits hepatocellular carcinoma cell migration and invasion through OGA-mediated O-GlcNAcylation of ZEB1

  2025cites this paper
• Artesunate reduces oxidative stress and inflammation in NAFLD by activating the Nrf2 pathway.

  2025cites this paper
• Topical Application of Artesunate Ameliorates Psoriatic Keratinization and Inflammation via Molecular Modulations Based on Both Human and Mouse Models

  2025cites this paper
• A comprehensive review of artesunate-induced organ toxicity: mechanisms, resistance, biomarkers, and protective strategies.

  2025cites this paper
• Natural products in the treatment of autoimmune hepatitis: A comprehensive review of therapeutic potential and mechanisms.

  2025cites this paper
• Studies on the Critical Therapeutic Role of Artemisinin and its Derivatives in Melanoma: a Review of Preclinical Evidence

  2025cites this paper
• Microglial-mediated immune mechanisms in autoimmune uveitis: Elucidating pathogenic pathways and targeted therapeutics.

  2024cites this paper
• Artesunate: a potential drug for the prevention and treatment from hepatitis to hepatocellular carcinoma.

  2024cites this paper